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24 February 2021 | Story NONSINDISO QWABE | Photo Supplied
Business Management Lecturer, Lebohang Masoabi, who received her MA in Business Management at the February virtual graduation ceremony.

Student-turned-lecturer at the University of Free State (UFS), Lebohang Masoabi, has experienced the best of both worlds. Masoabi, a Business Management Lecturer on the Qwaqwa Campus, received her MA degree with specialisation in Business Management during the ceremony for master’s and doctoral degrees on 24 February 2021. 
She obtained both her BA Corporate Marketing and Communication and BAHons in Business Management degrees from the UFS.

I found my passion and remembered why I started

Masoabi knows a little about delays not being denials, because what was initially supposed to be a two-year qualification took her five years to complete. “It’s been a long journey, and I really have been through a lot to get to this point. Along the way, I lost hope and was ready to give up, but I remembered why I started. Being an academic has always been a dream of mine, and I want to be the best at that, so I remembered that this was my dream, something that I love.”
“Passing on the knowledge that I have learned from this very university is incredible. I think we are one of the most awesome institutions, and I say this with confidence – having been a student myself, and now as an employee of this institution. At one point I was on the receiving end and knowledge was transferred to me, and now I am on the other side transferring that very same knowledge. Now that I am here, I want more. I see myself becoming Professor Lebohang Masoabi one day,” she said.

Entrepreneurship education necessary for students 
Masoabi’s study focused on the role of entrepreneurship education on the attitudes and intentions of university students. She said when she came up with the topic of the study, one of her concerns was that many students studying entrepreneurship did not know what to do with their degrees beyond university, while students in other streams who went on to start businesses after getting their qualifications, lacked the skill and know-how. Her study found that entrepreneurship education had a positive influence on the intentions of students who had entrepreneurship background.

“Entrepreneurship teaches you to cultivate unique skills and to think out of the box. It creates opportunities, which is necessary in a country like ours. If students are given the skills and background of entrepreneurship – with the right opportunities and confidence they get from us as lecturers – they are able to influence their surroundings,” she said.

Master’s degree a message of hope

Masoabi is currently pursuing her PhD in social entrepreneurship, and said her focus was on becoming an expert in the field. “Part of why I started this journey was because of the hope that was given to me as a student at the UFS, the hope that I can be whatever I want to be. This master’s degree is my message of hope to someone looking at my life.”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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