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28 January 2021 | Story Igno van Niekerk | Photo Supplied
Pictured from the left: Lucas Erasmus from the Department of Physics, Piet le Roux from the Astronomical Society of SA – Bloemfontein, Quinton Kaplan from the Department of Physics, Thinus van der Merwe from the Astronomical Society of SA – Bloemfontein. Front: Prof Matie Hoffman

In his book, The World is Flat, Thomas Friedman mentions how at first countries, then companies, and eventually communities went global. In true flat-world fashion, a combined team of the University of the Free State (UFS) and the Astronomical Society of South Africa – led by Prof Matie Hoffman, Associate Professor in the Department of Physics – participated in a once-in-a-lifetime event with their counterparts from the Ellinogermaniki Agogi School and the Skinakas Observatory in Greece.

On 21 December 2020, Earth was treated to the Jupiter-Saturn conjunction, when the two planets were only 0.1 degrees apart in the sky. Although conjunctions are regular phenomena, NASA mentions that the great conjunction of Jupiter and Saturn in 2020 was the closest since 1623 and the closest observable since 1226! A pinkie finger at arm’s length could cover both planets – although they were still millions of kilometres apart in space.

Planning started months ahead of the event, with the Ellinogermaniki Agogi Observatory in Greece and the Boyden Observatory in Bloemfontein chosen as the two selected vantage points. From both the Southern and Northern Hemisphere, the conjunction would be broadcast live on YouTube. As with any other technical project on an international scale, challenges arose. For example, in the Northern Hemisphere, it was already dark at 17:45 while the South African astronomers were still basking in sunlight until after 19:00. The conjunction would only be visible from South Africa after 19:30, almost two hours after it would be visible in Athens. The time was well used, with the event including a word of welcome by the Consul General of Greece in South Africa, Ioannis Chatzantonakis, presentations on Saturn and Jupiter, as well as a virtual tour of the Boyden Observatory, emphasising its connection with Greece through its first Director, Stefanos Paraskevopoulos. 

On Saturday, 19 December, the teams ‘gathered’ on opposite sides of planet Earth to do a dry run. One could sense the urgency and tension as both teams realised that they would have a huge captive audience on YouTube, and plans had to be made in case of connectivity challenges and if the weather did not allow the conjunction. As preparations progressed, Prof Hoffman was talking to his Greek counterparts and was simultaneously walking around with his laptop to share the landscape and activities via his webcam with colleagues in Greece. 

Monday 21 December 2020 – the weather prediction was correct. Clouds covered the Free State sky and scattered raindrops started to fall. Revert to Plan B. A recording made on Saturday evening was shared via the YouTube link, while a live feed of the conjunction from elsewhere in South Africa was arranged. From both sides of the world, information was shared about the history of the venues, as well as the marvel of what was happening in space. Fortunately, expert planetary photographer Clyde Foster was able to share a live feed just after 19:30 from the observatory at his home in Centurion, Gauteng. Those attending the event where visuals and speakers were together on one screen – yet thousands of kilometres apart – watching an event in outer space, will indeed agree with Thomas Friedman: the world is flat. The live-stream event of the conjunction was a catalyst that will result in continued collaboration between the UFS and colleagues in Greece in the field of astronomy. 

By the time of this writing, the livestream has reached more than 50 000 people.


News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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