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28 January 2021 | Story Igno van Niekerk | Photo Supplied
Pictured from the left: Lucas Erasmus from the Department of Physics, Piet le Roux from the Astronomical Society of SA – Bloemfontein, Quinton Kaplan from the Department of Physics, Thinus van der Merwe from the Astronomical Society of SA – Bloemfontein. Front: Prof Matie Hoffman

In his book, The World is Flat, Thomas Friedman mentions how at first countries, then companies, and eventually communities went global. In true flat-world fashion, a combined team of the University of the Free State (UFS) and the Astronomical Society of South Africa – led by Prof Matie Hoffman, Associate Professor in the Department of Physics – participated in a once-in-a-lifetime event with their counterparts from the Ellinogermaniki Agogi School and the Skinakas Observatory in Greece.

On 21 December 2020, Earth was treated to the Jupiter-Saturn conjunction, when the two planets were only 0.1 degrees apart in the sky. Although conjunctions are regular phenomena, NASA mentions that the great conjunction of Jupiter and Saturn in 2020 was the closest since 1623 and the closest observable since 1226! A pinkie finger at arm’s length could cover both planets – although they were still millions of kilometres apart in space.

Planning started months ahead of the event, with the Ellinogermaniki Agogi Observatory in Greece and the Boyden Observatory in Bloemfontein chosen as the two selected vantage points. From both the Southern and Northern Hemisphere, the conjunction would be broadcast live on YouTube. As with any other technical project on an international scale, challenges arose. For example, in the Northern Hemisphere, it was already dark at 17:45 while the South African astronomers were still basking in sunlight until after 19:00. The conjunction would only be visible from South Africa after 19:30, almost two hours after it would be visible in Athens. The time was well used, with the event including a word of welcome by the Consul General of Greece in South Africa, Ioannis Chatzantonakis, presentations on Saturn and Jupiter, as well as a virtual tour of the Boyden Observatory, emphasising its connection with Greece through its first Director, Stefanos Paraskevopoulos. 

On Saturday, 19 December, the teams ‘gathered’ on opposite sides of planet Earth to do a dry run. One could sense the urgency and tension as both teams realised that they would have a huge captive audience on YouTube, and plans had to be made in case of connectivity challenges and if the weather did not allow the conjunction. As preparations progressed, Prof Hoffman was talking to his Greek counterparts and was simultaneously walking around with his laptop to share the landscape and activities via his webcam with colleagues in Greece. 

Monday 21 December 2020 – the weather prediction was correct. Clouds covered the Free State sky and scattered raindrops started to fall. Revert to Plan B. A recording made on Saturday evening was shared via the YouTube link, while a live feed of the conjunction from elsewhere in South Africa was arranged. From both sides of the world, information was shared about the history of the venues, as well as the marvel of what was happening in space. Fortunately, expert planetary photographer Clyde Foster was able to share a live feed just after 19:30 from the observatory at his home in Centurion, Gauteng. Those attending the event where visuals and speakers were together on one screen – yet thousands of kilometres apart – watching an event in outer space, will indeed agree with Thomas Friedman: the world is flat. The live-stream event of the conjunction was a catalyst that will result in continued collaboration between the UFS and colleagues in Greece in the field of astronomy. 

By the time of this writing, the livestream has reached more than 50 000 people.


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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