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30 June 2021 | Story Dr Nitha Ramnath
Dr Charlene Marais, Prof Vladimir Azov and Prof Ulrich Hennecke

The Department of Chemistry at the University of the Free State (UFS) held a successful online International Symposium on Organic Chemistry on 15 June 2021. The symposium brought together scientists from several South African and foreign universities and created a virtual platform for a long-awaited discussion stalled by the COVID-19 pandemic. About 20 participants from universities in South Africa, Belgium, and Germany presented their lectures during the symposium. In addition, this symposium was directed at the postgraduate students in the Department of Chemistry at the UFS, allowing them to present their results to an international audience and to foster their engagement in scientific research.

For more than a year, the COVID-19 pandemic has prevented the common personal communication avenues for the researchers: face-to-face (F2F) conferences, symposia, and workshops. To bridge this gap, Prof Vladimir Azov and Dr Charlene Marais from the Department of Chemistry organised the online meeting for the researchers from the UFS and several other local and foreign universities, all working in the field of organic chemistry.

Online material from the International Symposium on Organic Chemistry is available at here

Collaborative project between the UFS and VUB towards the development of gel-based drug release systems

The symposium also served as a long-awaited inception meeting for the collaborative project between the Organic Chemistry group at the UFS and the Organic Chemistry (ORGC) group at the Vrije Universiteit Brussel (VUB). This project is jointly funded by the National Research Foundation (NRF) and FWO (Research Foundation – Flanders); it is aimed at the development of new peptide-based materials with properties controllable by precisely tuned interactions of unnatural amino acids included in the peptide sequence. Such peptides can, for example, be used as smart materials for precisely controllable drug release. The South African team members, directed by Prof Vladimir Azov, will specialise in the development of the new amino acid building blocks, whereas the VUB team, headed by Prof Ulrich Hennecke, will focus on peptide preparation and studies on their properties.

This kick-off meeting was initially planned as a F2F event in June 2020 but was delayed due to the COVID-19 travelling restrictions and finally migrated to a virtual space. This provided an opportunity to present the project proposals and to discuss the initial results in a much broader circle than would have been possible within the common F2F meeting framework.

News Archive

Researchers receive study grant for research into Congo Fever
2015-03-10

UFS researchers will be contributing significantly to the search for a vaccine against the deadly tick-borne disease known as Congo Fever.

Prof Felicity Burt from the Department of Medical Microbiology and Virology was recently awarded a research grant by the National Health Laboratory Service (NHLS) to study candidate vaccines for Crimean-Congo heamorrhagic fever (CCHF) virus and other arboviruses.

Arboviruses are viruses transmitted by mosquitoes, ticks, or other arthropods.

Prof Burt is an internationally-recognised expert on the Crimean-Congo haemorrhagic fever (CCHF). The Crimean-Congo haemorrhagic fever (CCHF) virus is a tick-borne virus that is associated with severe haemorrhagic disease in South Africa and other parts of Africa, Asia, and eastern Europe. Her interests focus on medically significant viruses that are transmitted by ticks and mosquitoes. Her research group is involved in determining the immune responses that are induced by different viral proteins.

Crimean-Congo haemorrhagic fever (CCHF) virus, a tick- borne virus found in Africa, Asia, the Balkans, and eastern Europe, causes severe viral haemorrhagic fever outbreaks.

Although a number of tick species are capable of becoming infected with CCHF virus, ticks of the genus Hyalomma, commonly referred to in SA as the “bont-legged ticks”, are the principal vector. The ticks have distinctive brown and white bands on their legs.

In February 1981, the first case of CCHF was recognised in South Africa (SA). To date, there have been nearly 200 cases of CCHF infection in SA with a 20% fatality rate. The majority of cases occurring in SA were in patients from the Northern Cape and Free State provinces.

“The funding that has been awarded will be used to profile immune responses against CCHF viral proteins, and investigate mechanisms and strategies to enhance these immune responses. We hope that the study will contribute knowledge towards the development of a vaccine against this medically significant virus.”

For more information or enquiries contact news@ufs.ac.za.

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