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30 June 2021 | Story André Damons | Photo André Damons
Dr Nicholas Pearce, Head of the COVID-19 Task Team at the Universitas Academic Hospital, leads a dedicated team of professionals at the testing and vaccination site of the Universitas Academic Hospital, adjacent to our Bloemfontein Campus.

It is impossible to quantify the number of hours Dr Nicholas Pearce, Head of the COVID-19 Task Team for the Universitas Academic Hospital, spent working in response to this deadly virus since the first case was reported in South Africa last year. 

According to Dr Pearce, who is the Head of the Department of General Surgery in the Faculty of Health Sciences at the University of the Free State (UFS), the initial preparation phase required many hours of brainstorming, planning, and physical hours working on site. He also spent countless hours awake at night trying to come up with solutions for the many challenges faced along the way. This is in addition to being available telephonically twenty-four-seven for any issues related to equipment, staffing, and facilities.

“I was attending a vascular surgery congress in Germany last year January (2020) when China just announced the outbreak of COVID-19. I noticed an increased number of travellers wearing surgical masks at an airport in the Middle East when I was travelling to South Africa. 

“Upon my return to work, I approached management to discuss procurement of PPEs, as it was just a matter of time before COVID-19 would hit South Africa and the rest of the world. When things escalated, I was asked to head the COVID-19 response team at Universitas Hospital,” explains Dr Pearce.

Kind human being with a soft heart

(Photo: André Damons)

Dr Pearce, who was brought up to always strive to be better, is driven and motivated to succeed. He has a very analytical brain and loves challenges. In fact, he does not believe in problems and only sees challenges. This kind human being can sometimes seem quite tough on the outside, but actually has a very soft heart. 

“I think it is human nature to want to feel needed. I have an inherent urge to help my fellow human beings. This is also the reason why I became a health-care professional and why I am passionate about teaching,” says Dr Pearce. 

With South Africa lagging behind with its vaccination programme, the hard work is far from over for Dr Pearce and his team. Says Dr Pearce: “The initiation of a mass vaccination site posed a whole new set of challenges, which once again required many hours of planning. The initial stages of running the vaccination site required many hours of physical hard work a day. Then there is also the daily operations meeting at 18:00 every weekday to discuss the vaccine roll-out in the province.”

Frustrations and setbacks

For Dr Pearce, this pandemic highlighted the differences between individuals from different social classes in our country. Providing quarantine and self-isolation facilities for individuals who do not have access to such facilities at home is one such example. 

“We all have a right to clean water and good quality healthcare. This also includes a right to oxygen. This right to oxygen has proved to be one of our great challenges in managing this pandemic. Delivery of these large amounts of oxygen has been especially challenging. Some days we require in excess of five tons of oxygen,” says Dr Pearce. 

(Photo: André Damons)


There have been many frustrations and setbacks on this journey, some of which can be quite demoralising and demotivating, but knowing that he is doing something good for his fellow human beings gives this gentle and diligent healthcare worker a tremendous amount of energy. “Positive feedback from patients and colleagues far outshines all the frustrations and disappointments,” concludes Dr Pearce. 


Outside of work

After finishing online meetings at home, Dr Pearce relaxes with his partner by chatting about the day’s events and cooking supper together while enjoying a glass of wine. He also tries to connect with family who lives in Gauteng. Because of work pressures and the pandemic, he has not been able to see them as much. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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