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21 June 2021 Photo Supplied
Carmien Tolmie
Dr Carmien Tolmie says being involved in the Global Challenges Research Fund (GCRF) START grant over the past three years has made a very concrete contribution to her career as a young scientist.

Dr Carmien Tolmie – Lecturer in the Department of Microbiology and Biochemistry at the University of the Free State (UFS) – is one of 30 postdoctoral research assistants in the United Kingdom and Africa who have benefited from the £3,7 M Global Challenges Research Fund (GCRF) START grant over the past three years. The grant was made available by the Science and Technology Facilities Council (STFC) in support of the Synchrotron Techniques for African Research and Technology (START) programme. The STFC is based in the United Kingdom.

The grant seeks to build partnerships between world-leading scientists in Africa and the UK who are working on research using synchrotron science. Forming part of this collaboration is the UK’s national synchrotron, Diamond Light Source (Diamond). The synchrotron, one of about 70 in the world, can be explained as a large machine, almost the size of a football field, which accelerates electrons to nearly the speed of light. According to Diamond, these fast-moving electrons produce very bright light, called synchrotron light. Scientists can use this light to study minute matter such as atoms and molecules.

 

Celebrating a new generation of scientists

On 7 June 2021, GCRF START celebrated its successes of the past years via a virtual event, including the new generation of scientists they trained. Diamond Light Source (Diamond) hosted the event.

In a statement issued by Diamond Light Source, Dr Tolmie was said to be one of the rising stars in the newly emerging Structural Biology network in South Africa. The statement reads that Dr Tolmie has made great strides with biocatalysis, investigating enzymes as drug targets for fungal infectious diseases that claim many lives, especially among immunocompromised patients.

Dr Tolmie claims that the workings of the natural world have always interested her, especially how it can be used to sustainably improve human health and agriculture. Observing some of the health challenges in Africa motivated her to take the opportunity to work with Prof Dirk Opperman, Associate Professor in the UFS Department of Microbiology and Biochemistry. Prof Opperman is a GCRF START co-investigator in the UFS Biocatalysis and Structural Biology research group, working on various bacterial and fungal enzymes.

Focusing on structural biology, Dr Tolmie is also working on drug discovery projects to find a sustainable solution through novel antifungal drugs.

To conduct the research that can improve the health of so many people suffering from infectious fungal diseases that can be serious, especially for immunocompromised patients living with HIV/Aids, recipients of organ transplants, patients undergoing chemotherapy and many more, Dr Tolmie will be using the drug discovery method of X-ray crystallographic fragment screening at Diamond Light Source (Diamond). “I was introduced to the concept and power of fragment screening techniques during GCRF START meetings,” says Dr Tolmie.

A research visit to Diamond Light Source in the UK in 2019, where she learned more about the experimental workflow of XChem and the i04-1 beamline, also inspired her to embark on XChem projects for antifungal drug discovery.

 

Exposed to cutting-edge scientific techniques

She attributes her recent appointment as lecturer to the mentoring and training she received through the GCRF START grant, which also funded a secondment to Diamond and the University of Oxford, exposing her to cutting-edge scientific techniques such as XChem fragment screening.

Prof Chris Nicklin, Science Group Leader and Principal Investigator in the GCRF START grant programme, says by providing the new generation of synchrotron users with access to world-class equipment and investing in their skills and capacity, research in the UK and Africa has been enriched and deepened.

“Being involved in the START grant has made a very concrete contribution to my career as a young scientist. GCRF START has also exposed me to many esteemed international scientists and facilities,” says Dr Tolmie.

Specifically alluding to the research that Dr Tolmie is working on, Dr Gwyndaf Evans, START Life Sciences Principal Investigator and principal beamline scientist on Diamond’s VMXm beamline, says: “It has been rewarding to see the relatively modest investment of time and money have such a major impact on the sustainability of research expertise, on the development of careers in Africa, on access to large-scale facilities around the world, and on the nurturing of collaborations and networks in South Africa.”

He continues: “In structural biology, there have been valuable exchanges and collaborations, especially XChem laying the foundations for drug discovery work. START is the beginning of embedding the structural research culture in South Africa and other groups around the world. We look forward to what the future holds.”

Dr Tolmie, who completed her BSc degree in Molecular Biology and Biotechnology at Stellenbosch University, completed her postgraduate studies (BSc Honours degree, MSc, and PhD) at the UFS.

News Archive

Moshoeshoe - lessons from an African icon - by Prof Frederick Fourie
2004-11-03

(The full text of the article that appeared in City Press and Sunday Independent)

Our understanding of history informs our understanding of the present. No wonder the contestation over historical figures in South Africa’s past is so fierce and so divisive.
The question is: could it be any other way? I would like to think that it could; that black and white South Africans, across linguistic, cultural, religious and other divides, can develop a shared appreciation of our history – at least with certain periods and personalities as a starting point.

One such personality whose legacy I believe offers a possible platform for unifying our still divided country is King Moshoeshoe, who lived from 1786 to 1870, and is acknowledged as the founder of the Basotho.

King Moshoeshoe is the topic of a documentary that has been commissioned by the University of the Free State as part of its Centenary celebrations this year. It is part of a larger project to honour and research the legacy of Moshoeshoe. The documentary will be screened on SABC 2 at 21:00 on November 4th.

Moshoeshoe rose to prominence at a time of great upheaval and conflict in South Africa – the 19th century, a time when British colonialism was entrenching itself, when the Boer trekkers were migrating from the Cape and when numerous indigenous chiefdoms and groupings were engaged in territorial conquests. It was the time of the Difaqane, a period when society in the central parts of the later South Africa and Lesotho was fractured, destabilised and caught in a cycle of violence and aggression.

In this period Moshoeshoe displayed a unique and innovative model of leadership that resulted in reconciliation, peace and stability in the area that later became Lesotho and Free State. It made him stand out from many of his contemporaries and also caught the attention of his colonial adversaries.

Such an evaluation is not a judgment about which model of leadership is right and which is wrong, or which leader was better than another; but merely an attempt to explore what we can learn from a particular exemplar.
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Historians point to the many progressive leadership qualities displayed by Moshoeshoe which he used effectively in establishing the Basotho nation and in defending it.
First, there is his humanism and sense of justice worthy of any great statesman. Confronted by a situation in which cannibals murdered and devoured his grandfather, Moshoeshoe chose not to take revenge. Instead he opted to rehabilitate them and feed them as he believed hunger drove them to cannibalism.

Secondly, there is his skilful alliance-building with his contemporaries such as Shaka in an attempt to neutralize those rivals who were intent on attacking his followers. This is also displayed in the way he sought the protection of the British to keep the Boer forces at bay.
Thirdly, his emphasis on peaceful options is also seen in his defensive military strategy which saw him retreat to a mountain fortress to be able to protect and build a burgeoning nation in the face of the many forces threatening its survival.

Fourthly, there is his remarkable inclusivity and tolerance for diversity which saw him unite disparate groups of refugees from the violence and hunger that displaced them and then weld them into the Basotho nation. He also engaged with French missionaries, inviting them to stay with him and advise him on Western thought, technology and religion.
These are but some of the qualities which belie the notion that all 19th century African leaders were merely marauders and conquerors that gained their ascendancy through violence. Instead Moshoeshoe is a prime example of the human-centred, democratic and pluralist roots of South African, indeed African society.

The Moshoeshoe project that we have initiated (of which the documentary, called “The Renaissance King”, forms but one part) derives from our location as a university in the Free State, a province with a particular history and a particular political culture that developed as a result of this very model of leadership. This province has benefited tremendously from leaders such as Moshoeshoe and president MT Steyn, both of whom many observers credit with establishing a climate of tolerance, respect for diversity of opinion, political accommodation and peaceful methods of pursuing political objectives in the province. Their legacy is real – and Moshoeshoe’s role can not be overstated.
In addition the project derives from the University of the Free State being a site of higher learning in a broader geo-political sense. As a university in Africa we are called upon to understand and critically engage with this history, this context and this legacy.
Besides the documentary, the UFS is also planning to establish an annual Moshoeshoe memorial lecture which will focus on and interrogate models of African leadership, nation-building, reconciliation, diversity management and political tolerance.

In tackling such projects, there may be a temptation to engage in myth-making. It is a trap we must be wary of, especially as an institution of higher learning. We need to ask critical questions about some aspects of Moshoeshoe’s leadership but of current political leadership as well. Thus there is a need for rigorous academic research into aspects of the Moshoeshoe legacy in particular but also into these above-mentioned issues.
While the documentary was commissioned to coincide with the University of the Free State’s centenary and our country’s ten years of democracy, it is a project that has a much wider significance. It is an attempt to get people talking about our past and about our future, as a campus, as a province and as a country – even as a continent, given the NEPAD initiatives to promote democracy and good governance.

The project therefore has particular relevance for the continued transformation of institutions such as universities and the transformation of our society. Hopefully it will assist those who are confronted by the question how to bring about new institutional cultures or even a national political culture that is truly inclusive, tolerant, democratic, non-sexist, non-racial, multilingual and multicultural.

I believe that the Moshoeshoe model of leadership can be emulated and provide some point of convergence. A fractured society such as ours needs points of convergence, icons and heroes which we can share. Moshoeshoe is one such an African icon – in a world with too few of them.

Prof Frederick Fourie is the Rector and Vice-Chancellor of the University of the Free State

* The documentary on “Moshoeshoe: The Renaissance King” will be screened on SABC2 on 4 November 2004 at 21:00.

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