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15 June 2021 | Story Leonie Bolleurs | Photo Supplied
Zurika Murray says the study of Behavioural Genetics at the UFS focuses on human behaviour, specifically neurotransmitter systems, such as serotonin that may contribute to specific behavioural patterns.
Zurika Murray says the study of Behavioural Genetics at the UFS focuses on human behaviour, specifically neurotransmitter systems, such as serotonin that may contribute to specific behavioural patterns.

Hi. I am John. I have anger issues.

Just like John, there are thousands of South Africans with anger issues, often leading to violent crimes such as the more than 21 000 murder cases and 165 000 plus assault cases reported in 2020, according to a study by the South African Police Service and Statistics South Africa.

Aggression can be a great threat to society when it leads to violence. However, it can also be an absolute necessity when it leads to perseverance and a drive towards success and survival. This is according to Zurika Murray, a lecturer in the Department of Genetics at the University of the Free State (UFS), who is doing research on behavioural genetics.

 

Behavioural genetics

She explains behavioural genetics as a study of genetic variation contributing to how an organism interacts with and within its environment. “At the UFS, we focus on human behaviour, and specifically neurotransmitter systems, such as serotonin that may contribute to specific behavioural patterns.”

When one has the right amount of serotonin in your body, it is easier to have stable moods and a sense of well-being.

She says the neurotransmitter (which plays a role in, among others, emotional regulation) acts as a mediator, relaying messages and influencing response to environmental stimuli.  “This system is very adaptable, facilitating our functioning in an ever-changing emotional environment; but when dysfunctional, it can cause quite a number of abnormalities, from anxiety and depression to dysfunctional impulse control and violence. When some individuals are exposed to adverse developmental environments such as abuse and neglect, they can develop aggression and violence.”

“One of our current projects looks specifically at male juvenile delinquency and monoamine neurotransmitter systems (such as serotonin) that may contribute to specific characteristics (such as impulsivity) of delinquency.”

According to Murray, their research is also looking at the genetic variation within specific neurotransmitter genes to see if they could find similarities among individuals with similar developmental backgrounds.  “This neurotransmitter system additionally responds relatively well to physical activity as a management strategy for aggression in some individuals. We are looking at variations in this system that might explain this,” says Murray.

 

Genetic counselling

Apart from the genetic contribution, we also know that the developmental environment plays a very important role. Many people observe anger while growing up – it was thus part of their developmental environment. For them, it is appropriate behaviour in specific situations.

To understand this contribution from the developmental environment, a background in psychology is necessary.  The undergraduate degree in Behavioural Genetics at the UFS has Genetics and Psychology as majors, and this is where the link to genetic counselling comes in.

Murray explains that genetic counselling is a field in medical sciences focusing on helping patients affected by medical conditions to understand the underlying genetics.  For individuals with a family history of genetic conditions (such as specific cancers) or pregnant mothers with foetuses affected by genetic abnormalities (such as Down syndrome), the services of a genetic counsellor are invaluable.  A genetic counsellor will help these individuals understand the cause of the disorder, how it was diagnosed, what the symptoms are, what the progression will look like, if any treatment is available, and what the possible options are (if any) for alternatives.

Genetic counsellors need a strong background in both Genetics and Psychology. To become a registered genetic counsellor, a student completes a BSc degree in Biological Sciences (Behavioural Genetics at the UFS would be ideal).  Thereafter an honours degree in either Genetics or Psychology (though Genetics is preferable).  The student can then apply at either the University of the Witwatersrand or the University of Cape Town for a master’s degree in Genetic Counselling.  This entails two years of study, followed by two years of practical internship. Only after this you will be able to register with the Health Professions Council of South Africa (HPCSA) as a genetic counsellor.

Students studying Behavioural Genetics at the UFS are off to a great start. Murray’s teaching philosophy is to always strive to deliver students who are better than she is. “I can only really do this by sharing my passion for my research. I hope to inspire my students to also always be hungrily curious, to always question, and to find the joy in knowledge and learning.”

News Archive

Early nutrition impacts on burden of disease
2017-11-15


 Description: Corinna Walsh read more Tags: Corinna Walsh read more

Prof Corinna Walsh during her inaugural lecture on ‘Nutrition in Transition’.
Photo: Stephen Collett 

“The first 1 000 days, from conception to two years, is a critical time to ensure that the early environment is optimal to guarantee the best outcomes,” Prof Corinna Walsh, Professor in the Department of Nutrition and Dietetics at the University of Free State (UFS), said. She delivered her inaugural lecture on Nutrition in Transition on 30 October 2017. 

During her lecture, Prof Walsh explained how an unfavourable early environment impacts on the health and well-being of both children and adults. She gave an overview of the prevalence of hunger and food insecurity in the Free State, and described the shift that has occurred from healthier traditional diets to more unhealthy Western diets accompanied by sedentary lifestyles. These patterns are closely linked to the triple burden of malnutrition, including undernutrition, micro-nutrient malnutrition, and obesity. Finally, Prof Walsh highlighted the double burden of disease, focusing on chronic lifestyle diseases on the one hand, and infectious diseases such as HIV/AIDS and TB on the other hand.

“Preparing for this lecture has given me the opportunity to reflect on the almost thirty years of my research journey, a process that I thoroughly enjoyed,” said Prof Walsh.

“It was a privilege to share the work of my research team with fellow colleagues as well as with family and friends,” she said. Prof Walsh is a National Research Foundation C-rated researcher and also served on the Board of the Medical Research Council from 2005 to 2010.

Foundations for health, growth established early
The first 1 000-day window focuses on the time between conception and the second birthday. “This is a critical period for growth and development,” Prof Walsh said. It is a unique period, as the foundations for health, growth, and neuro-development are established. It also focused on the implications of malnutrition, which is the biggest risk factor contributing to the global burden of disease.


Research identifies burden of disease
Her research has made a considerable contribution to identifying the burden of disease in the Free State. “It focuses on both malnutrition and infectious diseases such as HIV and TB on the one hand, and chronic lifestyle diseases such as obesity, diabetes, and hypertension on the other,” she said. The research team have also implemented a number of interventions to address these challenges, including programmes that have assessed the impact of nutrition-education programmes, household food gardens, and nutrition supplementation.

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