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15 June 2021 | Story Leonie Bolleurs | Photo Supplied
Zurika Murray says the study of Behavioural Genetics at the UFS focuses on human behaviour, specifically neurotransmitter systems, such as serotonin that may contribute to specific behavioural patterns.
Zurika Murray says the study of Behavioural Genetics at the UFS focuses on human behaviour, specifically neurotransmitter systems, such as serotonin that may contribute to specific behavioural patterns.

Hi. I am John. I have anger issues.

Just like John, there are thousands of South Africans with anger issues, often leading to violent crimes such as the more than 21 000 murder cases and 165 000 plus assault cases reported in 2020, according to a study by the South African Police Service and Statistics South Africa.

Aggression can be a great threat to society when it leads to violence. However, it can also be an absolute necessity when it leads to perseverance and a drive towards success and survival. This is according to Zurika Murray, a lecturer in the Department of Genetics at the University of the Free State (UFS), who is doing research on behavioural genetics.

 

Behavioural genetics

She explains behavioural genetics as a study of genetic variation contributing to how an organism interacts with and within its environment. “At the UFS, we focus on human behaviour, and specifically neurotransmitter systems, such as serotonin that may contribute to specific behavioural patterns.”

When one has the right amount of serotonin in your body, it is easier to have stable moods and a sense of well-being.

She says the neurotransmitter (which plays a role in, among others, emotional regulation) acts as a mediator, relaying messages and influencing response to environmental stimuli.  “This system is very adaptable, facilitating our functioning in an ever-changing emotional environment; but when dysfunctional, it can cause quite a number of abnormalities, from anxiety and depression to dysfunctional impulse control and violence. When some individuals are exposed to adverse developmental environments such as abuse and neglect, they can develop aggression and violence.”

“One of our current projects looks specifically at male juvenile delinquency and monoamine neurotransmitter systems (such as serotonin) that may contribute to specific characteristics (such as impulsivity) of delinquency.”

According to Murray, their research is also looking at the genetic variation within specific neurotransmitter genes to see if they could find similarities among individuals with similar developmental backgrounds.  “This neurotransmitter system additionally responds relatively well to physical activity as a management strategy for aggression in some individuals. We are looking at variations in this system that might explain this,” says Murray.

 

Genetic counselling

Apart from the genetic contribution, we also know that the developmental environment plays a very important role. Many people observe anger while growing up – it was thus part of their developmental environment. For them, it is appropriate behaviour in specific situations.

To understand this contribution from the developmental environment, a background in psychology is necessary.  The undergraduate degree in Behavioural Genetics at the UFS has Genetics and Psychology as majors, and this is where the link to genetic counselling comes in.

Murray explains that genetic counselling is a field in medical sciences focusing on helping patients affected by medical conditions to understand the underlying genetics.  For individuals with a family history of genetic conditions (such as specific cancers) or pregnant mothers with foetuses affected by genetic abnormalities (such as Down syndrome), the services of a genetic counsellor are invaluable.  A genetic counsellor will help these individuals understand the cause of the disorder, how it was diagnosed, what the symptoms are, what the progression will look like, if any treatment is available, and what the possible options are (if any) for alternatives.

Genetic counsellors need a strong background in both Genetics and Psychology. To become a registered genetic counsellor, a student completes a BSc degree in Biological Sciences (Behavioural Genetics at the UFS would be ideal).  Thereafter an honours degree in either Genetics or Psychology (though Genetics is preferable).  The student can then apply at either the University of the Witwatersrand or the University of Cape Town for a master’s degree in Genetic Counselling.  This entails two years of study, followed by two years of practical internship. Only after this you will be able to register with the Health Professions Council of South Africa (HPCSA) as a genetic counsellor.

Students studying Behavioural Genetics at the UFS are off to a great start. Murray’s teaching philosophy is to always strive to deliver students who are better than she is. “I can only really do this by sharing my passion for my research. I hope to inspire my students to also always be hungrily curious, to always question, and to find the joy in knowledge and learning.”

News Archive

UFS venture cleans up acid mine drainage
2015-07-06

The system that puts oxygen back into the water.

Photo: Supplied

South Africa is one of the most important mining countries in the world, beginning in the 1870s. Although the mining industry has been responsible for significant development and employment, it pollutes the environment and waters sources. Through the joint effort of a well-known mining company, the University of the Free State, and the Technology Innovation Agency (UFS/TIA) SAENSE Group, a new treatment for Acid Mine Drainage (AMD) has been developed.

The system treats the major contaminants found in acid mining wastewater effectively.  
 
The UFS remediation systems use a reservoir tank into which the AMD is pumped. The water then flows passively (without using energy) to the Barium Carbonate Dispersed Alkaline Substrate (BDAS) system. The metals and anions in the AMD react chemically with the barium carbonate and precipitate (form solids). The solids stay in the tank while the clean water is released.

The efficacy and applicability of the research was demonstrated on site in Belfast, Mpumalanga where the team constructed a pilot plant in July 2014. This patented technology has treated 1 814 400 litres of Acid Mine Drainage to date with an outflow water quality that satisfies the South African National Standards (SANS) 241:2006 & 2011 regulations for drinking water.   

Rohan Posthumus from the (UFS/TIA) SAENSE Group said: “At this stage, we do not recommend that the water should be used as drinking water, but certainly it can lower water usage in mines while finding application in dust suppression of washing processes. The team would like to complete a full characterisation of the final released water. There are currently no toxic by-products formed, and even very basic filtration can make the outflow drinking water.”

Prof Esta van Heerden’s research group from the Department of Microbial, Biochemical, and Food Biotechnology has been working on AMD research for some time, but the development of the BDAS system was started in 2013 by post-doctoral student, Dr Julio Castillo, and his junior researcher, Rohan Posthumus.

The data from the BDAS system have led to two publications in peer-reviewed journals as well as a registered patent.

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