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30 March 2021 | Story Prof Francis Petersen | Photo Sonia Small (Kaleidoscope Studios)
Prof Francis Petersen.

Systems, processes, and policies are not exactly things that grab the headlines or are popular topics for dinner conversations. But they become vital in times of crisis. 
And if there is one thing that we have learnt from the COVID-19 pandemic, it is that no amount of time, effort or resources should be spared to get them in place before disaster strikes, says Prof Francis Petersen.

During my own education and training in the field of engineering, I was constantly reminded of the value of systems: a set of components working together as parts of a mechanism or an interconnecting network; a complex whole. In subsequent years, I also realised time and time again how system principles can be applied equally successfully in management. In any organisation, systems ensure unified and stable operation. And in times of crisis, they prevent hysteria, uncertainty, and unnecessary waste of time.

Lessons learned in reaction to the pandemic

At the University of the Free State (UFS), we quickly learned the value of acting proactively when it comes to the COVID-19 pandemic, as well as getting sustainable systems in place that operated in unity. Amid all the uncertainty and change, we found that it was vital not to re-act in a knee-jerk manner and steered away from implementing random measures that did not consider the entire institution, its history (how it grew and developed up to this point in time), and its future (the altered, post-COVID-19 landscape).

Early reaction and a sustained focus on the period after the pandemic, characterised our response action. A UFS COVID-19 Task Team was already formed at the end of February 2020, as news of the first infections trickled in from Wuhan, China.

When the first South African COVID-19 infection was reported on 5 March 2020, a Special Executive Group moved into action. It had several focus areas: Teaching and Learning, Staff, Operations, Re-integration of Staff and Students on Campus, Finance, Risk and Legal, COVID-19 Science, and Future Thinking. We immediately began the migration to remote teaching and learning, which involved the training of staff, getting the material online, briefing students, procuring laptops, and zero rating the learning portals.

In mid-March 2020, staff who were able to, were asked to work from home. Events were postponed, staff and students were trained to work in a remote setting, and a moratorium was placed on international travel – even before a national lockdown was put in place by government.

In retrospect, this timely, holistic, systematic approach proved to be invaluable.

Learning from a global system

The pandemic also reinforced the lesson that no country is an island. We should learn from others, not repeat their mistakes, and not ignore their successes.

A successful system never operates in isolation, but is affected by, and has an influence on the systems around it.

As we are entering the vaccine phase of the pandemic, it is more vital than ever to maintain a ‘systems’ approach.  Now is not the time for shortcuts, untested remedies, and vague claims of efficiency. Now is the time for systematic implementation of tried and tested processes, developed over time and underscored by good science.

Our part in the vaccine production system

At the UFS, we are privileged to play a role on two important fronts: 

The South African National Control Laboratory for Biological Products (NCLBP) located on our Bloemfontein Campus, is performing the all-important task of vaccine-lot release. As the sole provider of this service in the country and one of only twelve World Health Organisation (WHO)-contracted laboratories worldwide for vaccine quality-control testing, it forms part of a carefully crafted regulatory system, which has been established, fine-tuned, and tested over many years to serve the interests of the global community.

Vaccines are biological medicines and some of the most complex pharmaceuticals available today. It is vital that their regulation be governed by scientific and not commercial or political principles. It is a role that should under no circumstances simply be given to the ‘lowest bidder’ or the one who promises ‘speedy delivery’.

The NCLBP did not get to play this regulatory role overnight. It was already established in 1997 after an extremely stringent audit by the National Regulatory Authority (NRA) and subsequent recommendations by the WHO.

This means that all its operations – from the way documents are compiled and stored, to the maintenance of equipment and infrastructure, as well as staff competency – are performed according to strict international guidelines and are continuously and closely monitored.

It forms part of an involved system with checks and balances in place to ensure that no mistakes are made. 

Similarly, FARMOVS – a wholly owned clinical research company of the UFS, together with several medical and scientific experts at the university –  has submitted a clinical trial protocol for approval to the South African Health Products Regulatory Authority (SAHPRA) to determine the efficacy of Ivermectin for COVID-19.
FARMOVS was systematically prepared and shaped for this role, having been involved in countless pharmaceutical trials, proving its own efficacy consistently over a protracted period.
Not only is it the only onsite ISO- (International Organisation for Standardisation) and GLP- (Good Laboratory Practice) certified bioanalytical laboratory on the African continent – it has continuously proven itself to adhere to the most rigorous international requirements over the past 47 years.   

It is extremely satisfying – and reassuring – to see how institutions like these two, rooted in sound science, and having proven their consistency, efficiency, and accuracy over many years, are now stepping up to the plate and performing the all-important functions for which they were painstakingly and systematically designed. 

‘Vaccine nationalism’

This pandemic has shown that, through the interconnectedness of our world, one country or region has an impact (in this particular case a health-impact) on other countries and regions. In this context, it is up to rich countries to ensure fair and equitable access to vaccines for poorer countries, and that the WHO proposal to request pharmaceutical companies to waive their intellectual property rights in this regard, should be supported. 

‘Good science’ more important than ever

Another thing the pandemic has highlighted, is the importance of good, sound science amid all the hype, speculation, and false news that unfortunately also characterise the COVID-19 era. 

The co-incidental meteoric rise in the popularity of social media has fuelled the fire of unverified and unscientific claims that are so often just lapped up by information consumers in the public sphere. Unfortunately, since we have entered the vaccine phase, this has become increasingly rife. 

Here, the role of universities as education and research facilities is becoming more important than ever. Not only do we need to provide and communicate the ‘good science’ that everyone craves. But instead of simply advising from the side-line, we should also be playing a vital practical role, actively applying our knowledge, resources, and expertise within the broader society we serve, as has been aptly demonstrated in our important role of vaccine regulating.

Role of universities in the post-pandemic era

Without a doubt, the pandemic has highlighted the importance of online learning, the huge need that exists to be properly equipped for this and has given us a powerful shove in a direction we were already advancing to.

But it has also shown us that, in the midst of increasing digitisation, our need for social and physical interaction remains. The isolation brought about by COVID-19 has taught us that we cannot only function as a digital society. This will probably lead to higher-education institutions presenting a blended mode of learning and teaching in the future; a combination of online learning and face-to-face interactions, ensuring that students still get to experience campus life and the valuable interactions that go with it. 

The pandemic has also helped to crystalise the way in which we as ‘generators of knowledge’ should interact with society. The recent rhetoric of anti-scientific world leaders has caused communities to become distrustful of universities and science. 

We need to actively work on building trust within communities again. And we can only do this by working closely with other sectors of society, gauging real needs, and working together as parts of a bigger system in order to find real, practical solutions that can be seen by everyone to make a positive change in different spheres of society. 

Every organisation, business, government, and institution benefit from having both visionaries and pragmatists.  The visionaries help us to imagine a future we want to live in. The pragmatists work out practical, doable, and sustainable steps to get there. 

Sometimes it becomes necessary for the activists and orators to step aside and create space for the scientists and administrators to systematically get on with what needs to be done.
While we are all eager to move beyond this period in our collective history, back to a world that resembles more of the ‘old normal’ we long for, we should not make hasty, ill-considered moves and take shortcuts to get there.

We should also see this period as our opportunity to push our boundaries, embrace the ‘new normal’, and be innovative in our thinking on how to stay there. 


(Prof Francis Petersen is a registered professional engineer and has served on the executive managements of higher-education institutions, science councils, and industry organisations.)

News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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