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12 May 2021 | Story Nonsindiso Qwabe | Photo Supplied
Puseletso Moqomo

A tale of sheer resistance and of never giving up, is what best describes University of the Free State student Puseletso Moqomo’s academic journey.

From changing studies three times, losing NSFAS funding, and not being able to pay her fees, to working as a cashier at a Bloemfontein filling station to fund her education, Moqomo has seen and done it all, and she says she wouldn’t change a single thing about her journey.

She received her Bachelor of Science degree in Microbiology and Genetics in the Faculty of Natural and Agricultural Sciences during the 2021 April virtual graduation ceremony. When asked what kept her going, she said, “I told myself that I would study hard and obtain my degree; no matter what came my way, I wouldn’t give up. I would be tired and unable to study, but I told my mind that I had to do what I had to do to advance.”

Moqomo first encountered financial exclusion when her application for NSFAS funding was not approved in 2016. She did not have the R6 830 that was required for registration, and therefore had to pause her studies indefinitely. She decided to look for a job to pay her fees, and in June of that year she was employed as a temporary cashier at the Engen filling station at Northridge Mall in Noordhoek. “I was embarrassed and ashamed when I lost my NSFAS funding but giving up was not one of the things on my mind. When I started working, I made it very clear that I didn’t want to be a permanent employee; I simply wanted to work enough to have money to pay my fees.”

Juggling work and school paid off 

She saved enough to be able to register again in January 2017, but she had to change degree programmes along the way. “After writing my November exams, I would go back to Engen so that I could save money for the following year’s registration. I would fail my modules but still try again,” she said.

NSFAS continued to pay for the rest of her fees, but in 2020, during her final year, she was told that she had exceeded the number of years she could receive funding. “I began working full time because I knew I might not get NSFAS funding even after appealing, so I would work night shifts from Friday to Sunday, then take a bath at work and go to class on Monday mornings. Through all of this, I told myself that I would pass, and I would pass well.”

Fortunately, after relating her whole story to NSFAS during her appeal, she received funding for her final year – which came on time too, as she had to be laid off work temporarily due to the COVID-19 pandemic. She went back to work again in November 2020 and saved enough money to register for a Postgraduate Certificate in Education (PGCE), which she is currently pursuing. She is also currently completing her teaching practical at Ikaelelo Senior Secondary School, where she matriculated in 2013. “I knew I wanted to continue with my studies, so I worked hard.”

“Giving up is not an option; some things do not come easily – not even a degree. For some it might be easy, but for others there will be hurdles that they will have to overcome, but you have to keep going.”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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