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10 November 2021 | Story Leonie Bolleurs | Photo Supplied
Prof Abdon Atangana was recently elected a fellow of The World Academy of Sciences (TWAS).

Prof Abdon Atangana, Professor of Applied Mathematics in the Institute for Groundwater Studies at the University of the Free State (UFS), was recently elected a fellow of The World Academy of Sciences (TWAS).

He also received the World Academy of Sciences Award for Mathematics (TWAS -Mohammad A. Hamdan, 2020) on 1 November 2021.

TWAS, described as the voice for science in the South, is working towards the advancement of science in developing countries and supports sustainable prosperity through research, education, policy, and diplomacy. 

Outstanding contribution to science

Prof Mohamed HA Hassan, President of TWAS, congratulated Prof Atangana on this prestigious achievement, “Your election as fellow is a clear recognition of your outstanding contribution to science and its promotion in the developing world. We will be honoured to have you among our members.”

Candidates elected as TWAS Fellows are scientists whose contributions to their respective fields of science meet internationally accepted standards of excellence, and they must have distinguished themselves in efforts to promote science in developing countries. 

Prof Atangana is known for his research to develop a new fractional operator, the Atangana-Baleanu operator, which is to model real-world problems. With this operator, he not only describes the rate at which something will change, but also account for disrupting factors that will help to produce better projections.

Among others, his models can advise people drilling for water by predicting how groundwater is flowing in a complex geological formation. Furthermore, his work can also be applied to predict the spread of infectious diseases among people in a settlement, forecasting the number of people who will be infected each day, the number of people who will recover, and the number of people who will die. 

These are only two examples of how his work can be applied to better the lives of people.

Promoting science in the developing world

Besides promoting science in the developing world, Prof Atangana’s work also contributes to the United Nations Sustainable Development Goals – the global goals as set in 2015 that call for ending poverty, protecting the planet, and ensuring that all people enjoy prosperity and peace.

Prof Atangana says the election as fellow is a clear recognition of his outstanding contribution to science and its promotion in the developing world. “My work over the past five years has made a great impact in all fields of science, technology, and engineering.”

To be elected as TWAS fellow in mathematics, made him the second South African researcher to be elected in the field of mathematics (the first person elected was Prof Reddy Batmanathan Dayanand, who was elected in 2003). This also placed him as the sixth African mathematician to be elected as a TWAS fellow.

Very recently, he also ranked number one in the world in mathematics, number 186 in the world in all the fields, and number one in Africa in all the fields, according to the Stanford list of 2% single-year table.

He was also named among the top 1% of scientists on the global Clarivate Web of Science list. Less than 6 200 or 0,1% of the world's researchers were included on this list in 2020, with no more than 10 of the scientists hailing from South Africa. 

Prof Atangana is also editor of more than 20 top-tier journals of applied mathematics and mathematics, and for some of these journals he was the first African to be selected as editor. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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