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30 November 2021 | Story Leonie Bolleurs | Photo Supplied
Prof Johan Meyer, Senior Professor in the Department of Mathematics and Applied Mathematics, says he is looking forward to learning from others in the field during this collaboration.

What do trees, black holes, earthquakes, and time structures have in common? 

The answer to this question is that these, in one way or the other, form the focus of some of the abstracts delivered during the Annual Congress of the South African Mathematical Society. The society has as its main objective the advancement of mathematics in South Africa. 

The Department of Mathematics and Applied Mathematics at the University of the Free State (UFS), in conjunction with the South African Mathematical Society (SAMS 2021), is hosting the 64th Annual Congress of the society this week (29 November to 1 December 2021).

Prof Johan Meyer, Senior Professor in the department, says the congress, which is being conducted online, is focusing on all aspects of mathematics research, including history and teaching.

Learning from others in the field

The congress, which aims to share the latest research results in mathematics, will be attended by staff and students from universities across South Africa as well as abroad. “Anyone from the public is, of course, welcome to attend or even share their results if they are also involved in mathematics research,” adds Prof Meyer. 

He says that he is looking forward to learning from others in the field during this collaboration. 

The congress will include discussions on more than 120 abstracts, covering category theory, algebra, topology, logic; functional analysis and operator theory; finite groups and combinatorial structures; graph theory and combinatorics; lie symmetries and nonlinear differential equations; and applied and numerical mathematics.

Array of interesting topics presented

“It is important in many areas of science and engineering to predict and to simulate rare, random events, the occurrence of which may have negative or even catastrophic consequences. Examples include internet server overflows, mechanical breakdowns, floods, and financial crashes. Rare events can also have a positive effect, triggering for example chemical reactions or driving genetic evolution via random mutations.” Prof Hugo Touchette from Stellenbosch University will be shedding some light on this interesting topic in his presentation on Predicting and simulating rare events.

Prof Jeandrew Brink, Associate Professor in the Department of Mathematics and Applied Mathematics at the UFS, is presenting a plenary session on the topic Determining the geometry of strong field space-times in spite of tacitly assuming the answer during every measurement. In South Africa, state-of-the art pulsar timing data from the MeerKAT telescope will make a considerable contribution to conducting GR orbital tests. Prof Brink comments on how pulsar timing tests differ from tests using gravitational wave detectors, as well as what we can learn from the framework already employed to perform pulsar timing measurements.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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