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12 November 2021 | Story Lunga Luthuli | Photo Andre Ferreira
UFS Council Chambe
The refurbished Council Chambers of the University of the Free State was recognised with a South African Institute of Architects Free State Regional Award for Architectural Projects.

Winning three South African Institute of Architects (SAIA) Free State Regional Awards is the embodiment of the University of the Free State’s (UFS) commitment to continually improve infrastructure and create accessible spaces. 

Two of the UFS projects – the Council Chambers and the Modular Lecture Space and Assessment Centre – emerged victorious in the category for Architectural Projects, while Prof Jonathan Noble, Head of the Department of Architecture, won an award in Category B – Work of Social Importance – for his book, The Architecture of Peter Rich: Conversations with Africa. 
SAIA members were invited to submit Free State- and Northern Cape-based projects, completed between 1 January 2019 and 31 March 2021, for regional adjudication by a panel of judges consisting of professional architects Jeremie Malan, Diaan van der Westhuizen, and Velka Laubscher.

Each participating project were visited on 29 and 30 September 2021; the panel  was ‘delighted with the quality of workmanship’. 

Velka Laubscher, President of the South African Institute of Architects in the Free State, says: “The Regional Awards Programme is held biennially, and each visited project was adjudicated and awarded based on merit, looking at design, aesthetics, commodity, and orientation. 

“The panel of adjudicators also follows specific guidelines to ensure that the process adheres to SAIA’s standards,” says Laubscher.

Nico Janse van Rensburg, Senior Director: University Estates at the UFS, says, “It is a great honour to receive these accolades, as our buildings are constructed on carefully controlled budgets, but still manage to exhibit a refinement in terms of architectural aesthetics. The recognition also reflects how the institution’s infrastructure performs compared to university buildings in general.”

The Department of Higher Education and Training recently recommended the UFS to other universities in the country to learn from the institution how to undertake infrastructural development while adhering to budget constraints. 

The main criteria for projects to receive SAIA recognition not only involve compliance with a functional programme, but should also deal intelligently with contextual informants, creating spaces that offer opportunities for meaningful interaction, and the use of materials and measures that are sympathetic to the environment in general, as well as to our local climate conditions.

“We welcome the recognition by the department, as it gives us an opportunity to also interact and learn from other universities, since there is always room for improvement. The university community can rest assured that the allocated budget is spent to reflect the institution’s objectives and to get value for money,” says Janse van Rensburg.

Anton Roodt, architect and urban planner from GXY Architects and Roodt Architects joint consultants, says: “The value for the University of the Free State lies in the fact that the university is seen, both by its internal and external stakeholders, as an institution that values the contribution that good architecture can add to academic programmes and projecting the image of the university as an enlightened institution.” 

Projects awarded with a ‘Regional Award for Architecture 2021’ will now be submitted for national adjudication to become eligible for a SAIA Award of Merit 2022 and a SAIA Award for Excellence 2022.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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