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01 October 2021 | Story Lunga Luthuli and Vicky Simpson | Photo Supplied
Anton Engelbrecht _ Farmovs researcher
Anton Engelbrecht, FARMOVS Bioanalysis Specialist.

“At FARMOVS, we have the opportunity to work with the world’s top pharmaceutical companies, where we form part of the evaluation of labelled and/or conjugated antigens and antibodies that are developed for accurate quantification of endogenous and pharmaceutical compounds. Alternatively, commercially available kits and reagents are also used for the same purpose if the sponsor cannot supply the customised antigens/antibodies. The developed assay methods are put through a rigorous validation assessment to confirm the selectivity, sensitivity, and robustness of the assay,” says Anton Engelbrecht, FARMOVS Bioanalysis Specialist. 

FARMOVS, affiliated to the University of the Free State and operating from the Bloemfontein Campus, is a leading clinical research organisation (CRO) with a unique advantage. As the only on-site ISO15189-accredited and GLP-certified pharmacokinetic laboratory on the African continent, with numerous successful inspections by leading international regulators, it offers the highest quality bioanalytical services in a variety of biological matrices for the development of pharmaceutical products.

Engelbrecht says: “The team of bioanalytical experts thrives on the excitement generated by new discoveries that lead to better treatment of a variety of physiological diseases.”

Advanced technology backed by 47 years of bioanalytical experience

The clinical research organisation prides itself on advanced technology, backed by 47 years of bioanalytical experience. It has developed more than 580 validated analytical methods that adhere to the International Council for Harmonisation and the US Food and Drug Administration (FDA) guidelines. FARMOVS’ analytical methods have been used in more than 3 000 pre-clinical and clinical trials, contributing to the manufacturing of pharmaceutical drugs that are now used by households across the globe.

At FARMOVS, Engelbrecht says, it is a “world filled with novel methods of analysis and subsequent technological integration that expands the horizons of clinical research forming an important part of the discovery and production of new life-saving medicines that is constantly improving the quality of life of people all over the world”.

Engelbrecht says: “New technology and innovation should be the building blocks of any laboratory, and among these are the three fastest sample production members of our Immunochemistry Laboratory team – the STARLet pipettors.”

“We chose the Microlab® STARLet apparatus by Hamilton, because of its ability to perform sample analysis in large quantities at a greater speed by means of robotic pipetting and robotic automated microplate reading, which is a semi-automated process.”

He shared his excitement about improvements in the field of immunoassay development for the purposes of pharmaceutical analysis. This involves the preparation of unique immunoanalytical reagents, analysis of new categories of compounds, methodology, and instrumentation. The most important examples in this field are the continuous development of bead-based immunoassays.

Staying competitive in the industry

Immunoassay methods, such as radioimmunoassay (RIA) and enzyme immunoassay (EIA), among others, are also used at FARMOVS to analyse macromolecules for clients. “The RIA method is used for the determination of several pharmaceutically important compounds in biological fluids. RIA requires a sample containing the antigen of interest, a complementary antibody, and a radiolabelled version of the antigen. To increase the selectivity of an assay, all samples are pre-treated to eliminate high molecular weight endogenous matrix components, including anti-drug antibodies,” explains Engelbrecht.

Although FARMOVS has adequate technology to provide market-related results, the plan is to expand the team to include a multiplex platform that is a sensitive, fully automated immunoassay platform with multiplexing and custom assay capability. “This will pave the way to use an even more sensitive method to quantify biomarkers in the fields of oncology, neurology, cardiology, inflammation, and infectious disease. We aim to remain competitive in our industry, so naturally we must recruit the brightest and most evolved to join the team,” he says.

News Archive

Two UFS architecture students won prestigious PG Bison 1.618 Competition
2017-10-26

 Description: Bison read more Tags: : Stephan Diedericks, Department of Architecture, Margaux Loubser, Kobus du Preez, Zack Wessels, PG Bison 1.168 Competition 

At the PG Bison 1.618 competition awards ceremony
in Rosebank, were from the left:
Camrin Plaatjes from the University of KwaZulu-Natal;
Stephan Diedericks, winner of the competition;
and Margaux Loubser,
the second-place winner. Both Stephan and
Margaux are studying Architecture at the UFS.
Photo: Supplied



Food that reaches its sell-by date in supermarkets is usually disposed of, but has not yet reached its best-before date.  What happens to this food?  According to Stephan Diedericks, the answer to this is for this food to be repurposed.

Not only does Stephan want to prevent the waste of food – in a world where food security is a challenge – but he also won the prestigious PG Bison 1.618 Competition with his entry in which he suggests that gourmet meals be prepared from food that has reached its sell-by date, and then be served in the Delta Recycletorium. 

Students introduced to park lands in urban areas
Diedericks is a student in the Department of Architecture at the University of the Free State (UFS). Second-place winner in this competition was Margaux Loubser, also a UFS student. Another UFS student, Dehan Kassimatis, was a finalist. They received their awards at a ceremony in Rosebank, Johannesburg, earlier this month. 

The competition, now in its 24th year, was created to recognise the future interior and industrial designers, architects, and key decision-makers in the South African construction industry. It is known not only for the prestige it offers its winners, but also for the tradition-defying brief given to the students each year.

According to lecturers Kobus du Preez and Zak Wessels, in the Department of Architecture, the competition introduced the students to parklands in urban areas. He quotes the competition brief: “Rural to urban migration with the development of commercial and residential property elevates the importance of parklands within cities, in creating a refuge from the hustle of daily life.  These areas are leveraged to encourage healthier living, community interaction and environmental awareness.”

Learning experience more important than prizes
The site that was the focus of the competition is the Environmental Centre, Delta Park Heritage Precinct in Johannesburg. Students needed to transform this old building into a vibrant gastronomic restaurant. “The theme and style of the restaurant was for the student to choose,” said Du Preez. 

Loubser called her restaurant Rooted – a wholefood restaurant.  She was influenced by the geometries of the original Art Deco building. Rooted articulates and integrates the space between nature and the building.  Similar to an Art Deco painting or poster, the landscape is abstracted into terraces which are used to grow vegetables organically.  Vertical green screens soften the divide between the building and its surroundings and it provides shade.

“Our students took their clues from the existing environment and integrated it with a single idea, an abstract concept, which impressed the judges,” Du Preez said. 

Although this is a competition that is well reported in the industry press, Du Preez and Wessels agree that the learning experience for students is much more important than winning the contest. The competition’s brief aligned well with the Department of Architecture’s learning content with its urban focus.

Jacques Steyn, a UFS architecture student, came third in the competition in 2015.

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