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01 October 2021 | Story Lunga Luthuli and Vicky Simpson | Photo Supplied
Anton Engelbrecht _ Farmovs researcher
Anton Engelbrecht, FARMOVS Bioanalysis Specialist.

“At FARMOVS, we have the opportunity to work with the world’s top pharmaceutical companies, where we form part of the evaluation of labelled and/or conjugated antigens and antibodies that are developed for accurate quantification of endogenous and pharmaceutical compounds. Alternatively, commercially available kits and reagents are also used for the same purpose if the sponsor cannot supply the customised antigens/antibodies. The developed assay methods are put through a rigorous validation assessment to confirm the selectivity, sensitivity, and robustness of the assay,” says Anton Engelbrecht, FARMOVS Bioanalysis Specialist. 

FARMOVS, affiliated to the University of the Free State and operating from the Bloemfontein Campus, is a leading clinical research organisation (CRO) with a unique advantage. As the only on-site ISO15189-accredited and GLP-certified pharmacokinetic laboratory on the African continent, with numerous successful inspections by leading international regulators, it offers the highest quality bioanalytical services in a variety of biological matrices for the development of pharmaceutical products.

Engelbrecht says: “The team of bioanalytical experts thrives on the excitement generated by new discoveries that lead to better treatment of a variety of physiological diseases.”

Advanced technology backed by 47 years of bioanalytical experience

The clinical research organisation prides itself on advanced technology, backed by 47 years of bioanalytical experience. It has developed more than 580 validated analytical methods that adhere to the International Council for Harmonisation and the US Food and Drug Administration (FDA) guidelines. FARMOVS’ analytical methods have been used in more than 3 000 pre-clinical and clinical trials, contributing to the manufacturing of pharmaceutical drugs that are now used by households across the globe.

At FARMOVS, Engelbrecht says, it is a “world filled with novel methods of analysis and subsequent technological integration that expands the horizons of clinical research forming an important part of the discovery and production of new life-saving medicines that is constantly improving the quality of life of people all over the world”.

Engelbrecht says: “New technology and innovation should be the building blocks of any laboratory, and among these are the three fastest sample production members of our Immunochemistry Laboratory team – the STARLet pipettors.”

“We chose the Microlab® STARLet apparatus by Hamilton, because of its ability to perform sample analysis in large quantities at a greater speed by means of robotic pipetting and robotic automated microplate reading, which is a semi-automated process.”

He shared his excitement about improvements in the field of immunoassay development for the purposes of pharmaceutical analysis. This involves the preparation of unique immunoanalytical reagents, analysis of new categories of compounds, methodology, and instrumentation. The most important examples in this field are the continuous development of bead-based immunoassays.

Staying competitive in the industry

Immunoassay methods, such as radioimmunoassay (RIA) and enzyme immunoassay (EIA), among others, are also used at FARMOVS to analyse macromolecules for clients. “The RIA method is used for the determination of several pharmaceutically important compounds in biological fluids. RIA requires a sample containing the antigen of interest, a complementary antibody, and a radiolabelled version of the antigen. To increase the selectivity of an assay, all samples are pre-treated to eliminate high molecular weight endogenous matrix components, including anti-drug antibodies,” explains Engelbrecht.

Although FARMOVS has adequate technology to provide market-related results, the plan is to expand the team to include a multiplex platform that is a sensitive, fully automated immunoassay platform with multiplexing and custom assay capability. “This will pave the way to use an even more sensitive method to quantify biomarkers in the fields of oncology, neurology, cardiology, inflammation, and infectious disease. We aim to remain competitive in our industry, so naturally we must recruit the brightest and most evolved to join the team,” he says.

News Archive

Africa the birthplace of mathematics, says Prof Atangana
2017-11-17


 Description: Prof Abdon Atangana, African Award of Applied Mathematics  Tags: Prof Abdon Atangana, African Award of Applied Mathematics

Prof Abdon Atangana from the UFS Institute for Groundwater Studies.
Photo: Supplied

 

Prof Abdon Atangana from the Institute for Groundwater Studies at the University of the Free State recently received the African Award of Applied Mathematics during the International conference "African’s Days of Applied Mathematics" that was held in Errachidia, Morocco. Prof Atangana delivered the opening speech with the title "Africa was a temple of knowledge before: What happened?” The focus of the conference was to offer a forum for the promotion of mathematics and its applications in African countries.

When Europeans first came to Africa, they considered the architecture to be disorganised and thus primitive. It never occurred to them that Africans might have been using a form of mathematics that they hadn’t even discovered yet.

Africa is home to the world’s earliest known use of measuring and calculation. Thousands of years ago Africans were using numerals, algebra and geometry in daily life. “Our continent is the birthplace of both basic and advanced mathematics,” said Prof Atangana. 

Africa attracted a series of immigrants who spread knowledge from this continent to the rest of the world.

Measuring and counting
In one of his examples of African mathematics knowledge Prof Atangana referred to the oldest mathematical instrument as the Lebombo bone, a baboon fibula used as a measuring instrument, which was named after the Lebombo Mountains of Swaziland. The world’s oldest evidence of advanced mathematics was also a baboon fibula that was discovered in present-day Democratic Republic of Congo.

Another example he used is the manuscripts in the libraries of the Sankoré University, one of the world’s oldest tertiary institutions. This university in Timbuktu, Mali, is full of manuscripts mainly written in Ajami in the 1200s AD. “When Europeans and Western Asians began visiting and colonising Mali between the 1300s and 1800s, Malians hid the manuscripts in basements, attics and underground, fearing destruction or theft by foreigners. This was certainly a good idea, given the Europeans' history of destroying texts in Kemet and other areas of the continent. Many of the scripts were mathematical and astronomical in nature. In recent years, as many as 700 000 scripts have been rediscovered and attest to the continuous knowledge of advanced mathematics and science in Africa well before European colonisation. 

Fractal geometry

“One of Africa’s major achievements was the advanced knowledge of fractal geometry. This knowledge is found in a wide aspect of Africa life: from art, social design structures, architecture, to games, trade and divination systems. 

“The binary numeral system was also widely known through Africa before it was known throughout much of the world. There is a theory that it could have influenced Western geometry, which led to the development of digital computers,” he said. 

“Can Africa rise again?” Prof Atangana believes it can.

He concluded with a plea to fellow African researchers to do research that will build towards a new Africa.

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