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Anton Engelbrecht _ Farmovs researcher
Anton Engelbrecht, FARMOVS Bioanalysis Specialist.

“At FARMOVS, we have the opportunity to work with the world’s top pharmaceutical companies, where we form part of the evaluation of labelled and/or conjugated antigens and antibodies that are developed for accurate quantification of endogenous and pharmaceutical compounds. Alternatively, commercially available kits and reagents are also used for the same purpose if the sponsor cannot supply the customised antigens/antibodies. The developed assay methods are put through a rigorous validation assessment to confirm the selectivity, sensitivity, and robustness of the assay,” says Anton Engelbrecht, FARMOVS Bioanalysis Specialist. 

FARMOVS, affiliated to the University of the Free State and operating from the Bloemfontein Campus, is a leading clinical research organisation (CRO) with a unique advantage. As the only on-site ISO15189-accredited and GLP-certified pharmacokinetic laboratory on the African continent, with numerous successful inspections by leading international regulators, it offers the highest quality bioanalytical services in a variety of biological matrices for the development of pharmaceutical products.

Engelbrecht says: “The team of bioanalytical experts thrives on the excitement generated by new discoveries that lead to better treatment of a variety of physiological diseases.”

Advanced technology backed by 47 years of bioanalytical experience

The clinical research organisation prides itself on advanced technology, backed by 47 years of bioanalytical experience. It has developed more than 580 validated analytical methods that adhere to the International Council for Harmonisation and the US Food and Drug Administration (FDA) guidelines. FARMOVS’ analytical methods have been used in more than 3 000 pre-clinical and clinical trials, contributing to the manufacturing of pharmaceutical drugs that are now used by households across the globe.

At FARMOVS, Engelbrecht says, it is a “world filled with novel methods of analysis and subsequent technological integration that expands the horizons of clinical research forming an important part of the discovery and production of new life-saving medicines that is constantly improving the quality of life of people all over the world”.

Engelbrecht says: “New technology and innovation should be the building blocks of any laboratory, and among these are the three fastest sample production members of our Immunochemistry Laboratory team – the STARLet pipettors.”

“We chose the Microlab® STARLet apparatus by Hamilton, because of its ability to perform sample analysis in large quantities at a greater speed by means of robotic pipetting and robotic automated microplate reading, which is a semi-automated process.”

He shared his excitement about improvements in the field of immunoassay development for the purposes of pharmaceutical analysis. This involves the preparation of unique immunoanalytical reagents, analysis of new categories of compounds, methodology, and instrumentation. The most important examples in this field are the continuous development of bead-based immunoassays.

Staying competitive in the industry

Immunoassay methods, such as radioimmunoassay (RIA) and enzyme immunoassay (EIA), among others, are also used at FARMOVS to analyse macromolecules for clients. “The RIA method is used for the determination of several pharmaceutically important compounds in biological fluids. RIA requires a sample containing the antigen of interest, a complementary antibody, and a radiolabelled version of the antigen. To increase the selectivity of an assay, all samples are pre-treated to eliminate high molecular weight endogenous matrix components, including anti-drug antibodies,” explains Engelbrecht.

Although FARMOVS has adequate technology to provide market-related results, the plan is to expand the team to include a multiplex platform that is a sensitive, fully automated immunoassay platform with multiplexing and custom assay capability. “This will pave the way to use an even more sensitive method to quantify biomarkers in the fields of oncology, neurology, cardiology, inflammation, and infectious disease. We aim to remain competitive in our industry, so naturally we must recruit the brightest and most evolved to join the team,” he says.

News Archive

New projects will enhance the infrastructure on our campuses
2011-02-04

 
Illustration:
The university's Main Gate in Nelson Mandela Avenue, as designed by The Roodt Partnership Architects.
 

A new entrance to the Main Campus, a high-performance centre, commercial gymnasium, rock-climbing wall, memorial garden for women and a botanical garden are but a few of the number of building and renovation projects that will take place at the Main Campus of the University of the Free State (UFS) in Bloemfontein. A number of projects are also being done on the Qwaqwa Campus.
On the Main Campus the entrance in Nelson Mandela Avenue is being adapted to match the university’s new corporative identity which was introduced last week. This project will be completed at the end of March 2011,
 
The creation of an environment conducive to the development of its students in the field of teaching, learning and research, as well as sports and culture is one of the main reasons why the UFS is renovating existing buildings and developing new infrastructure.
 
With the construction of a high-performance centre and commercial gymnasium, the university wants to create a work environment for its staff that will not only contribute to the cultivation of maximum work performance, but also to staff wellness. The centre with its foyer and administrative offices will furthermore consist of a health desk, university sports institute, sports sales, a spinning and aerobic centre, and dressing rooms. The total area will extend over 2114 m² and the construction will take approximately 18 months. This development will take place on the western side of the university’s Main Campus, directly opposite the Furstenburg Gate and next to the new student housing.
 
The UFS is also progressing well with other building projects which commenced last year. One of the projects is a new Education Building which is being constructed opposite the UFS Sasol Library. Upon completion this building will be used for the training of maths and science teachers in the Foundation Phase. It will include three classrooms for 100 students each and an auditorium for 225 students as well as an office block. The auditorium will also be used as a classroom. The building has been designed according to environmentally friendly principles to save water and use power effectively. It should be completed this year.
 
Planning for the construction of more student accommodation on the Main Campus as well as the Qwaqwa Campus is already well underway. On the Qwaqwa Campus, a residence with 200 beds is being constructed. This also includes a computer laboratory. According to the planning, this residence should be completed by the end of the first semester in 2011. Furthermore, four residences will be constructed on the Main Campus. These residences are in the planning phase.
 
In order to place technology within reach of Kovsie students and thereby empowering them, computer laboratories were installed at the respective residences. The computer laboratories will eventually make provision for approximately185 computers for student use. Proper security is also planned to safeguard the equipment.
 
Work to a new building for the Faculty of Health Sciences is also proceeding rapidly on the site where the vehicle pool and Hertz were previously used. This will include a lecture hall for 200 students, five venues for 100 students each, as well as offices. Students from the School for Medicine and Occupational Therapy will make use of these facilities.
 
The new building for the Faculty of Economic and Management Sciences between the Flippie Groenewoud Building and the Wynand Mouton Theatre is also coming along nicely.
 
On the university’s Qwaqwa Campus a new Education building is being constructed. This building will include a lecturing hall with 100 seats, four 50-seat classrooms, six offices, ablution facilities, a biology and science laboratory, as well as an information technology laboratory for 60 students.
 
In the meantime, existing buildings are being renovated on all the campuses. This includes, amongst others, improvements to the Architecture Building, the Biotechnology Building and the quarters for service workers on the Main Campus. Other improvements that have already been completed include the renovation of the Odeion’s foyer and the Callie Human Centre.
 
In future, students, staff and visitors to the UFS can also look forward to a rock-climbing wall at the Student Centre on the Thakaneng Bridge, a memorial park for women, residential accommodation within a sports environment, and a botanical garden.

 

Media Release
03 February 2011
Issued by: Lacea Loader
Director: Strategic Communication (actg)
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: news@ufs.ac.za

 

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