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01 October 2021 | Story Lunga Luthuli and Vicky Simpson | Photo Supplied
Anton Engelbrecht _ Farmovs researcher
Anton Engelbrecht, FARMOVS Bioanalysis Specialist.

“At FARMOVS, we have the opportunity to work with the world’s top pharmaceutical companies, where we form part of the evaluation of labelled and/or conjugated antigens and antibodies that are developed for accurate quantification of endogenous and pharmaceutical compounds. Alternatively, commercially available kits and reagents are also used for the same purpose if the sponsor cannot supply the customised antigens/antibodies. The developed assay methods are put through a rigorous validation assessment to confirm the selectivity, sensitivity, and robustness of the assay,” says Anton Engelbrecht, FARMOVS Bioanalysis Specialist. 

FARMOVS, affiliated to the University of the Free State and operating from the Bloemfontein Campus, is a leading clinical research organisation (CRO) with a unique advantage. As the only on-site ISO15189-accredited and GLP-certified pharmacokinetic laboratory on the African continent, with numerous successful inspections by leading international regulators, it offers the highest quality bioanalytical services in a variety of biological matrices for the development of pharmaceutical products.

Engelbrecht says: “The team of bioanalytical experts thrives on the excitement generated by new discoveries that lead to better treatment of a variety of physiological diseases.”

Advanced technology backed by 47 years of bioanalytical experience

The clinical research organisation prides itself on advanced technology, backed by 47 years of bioanalytical experience. It has developed more than 580 validated analytical methods that adhere to the International Council for Harmonisation and the US Food and Drug Administration (FDA) guidelines. FARMOVS’ analytical methods have been used in more than 3 000 pre-clinical and clinical trials, contributing to the manufacturing of pharmaceutical drugs that are now used by households across the globe.

At FARMOVS, Engelbrecht says, it is a “world filled with novel methods of analysis and subsequent technological integration that expands the horizons of clinical research forming an important part of the discovery and production of new life-saving medicines that is constantly improving the quality of life of people all over the world”.

Engelbrecht says: “New technology and innovation should be the building blocks of any laboratory, and among these are the three fastest sample production members of our Immunochemistry Laboratory team – the STARLet pipettors.”

“We chose the Microlab® STARLet apparatus by Hamilton, because of its ability to perform sample analysis in large quantities at a greater speed by means of robotic pipetting and robotic automated microplate reading, which is a semi-automated process.”

He shared his excitement about improvements in the field of immunoassay development for the purposes of pharmaceutical analysis. This involves the preparation of unique immunoanalytical reagents, analysis of new categories of compounds, methodology, and instrumentation. The most important examples in this field are the continuous development of bead-based immunoassays.

Staying competitive in the industry

Immunoassay methods, such as radioimmunoassay (RIA) and enzyme immunoassay (EIA), among others, are also used at FARMOVS to analyse macromolecules for clients. “The RIA method is used for the determination of several pharmaceutically important compounds in biological fluids. RIA requires a sample containing the antigen of interest, a complementary antibody, and a radiolabelled version of the antigen. To increase the selectivity of an assay, all samples are pre-treated to eliminate high molecular weight endogenous matrix components, including anti-drug antibodies,” explains Engelbrecht.

Although FARMOVS has adequate technology to provide market-related results, the plan is to expand the team to include a multiplex platform that is a sensitive, fully automated immunoassay platform with multiplexing and custom assay capability. “This will pave the way to use an even more sensitive method to quantify biomarkers in the fields of oncology, neurology, cardiology, inflammation, and infectious disease. We aim to remain competitive in our industry, so naturally we must recruit the brightest and most evolved to join the team,” he says.

News Archive

UFS academic delivers inaugural lecture on challenges confronting political science in the 21st century
2012-10-12

Prof. Hussein Solomon.
Photo: Stephen Collett
12 October 2012

This week Prof. Hussein Solomon, Senior Professor in the Department of Political Studies and Governance delivered his inaugural lecture on the Bloemfontein Campus of the University of the Free State (UFS).

In his lecture, “Challenges confronting political science in the 21st century, A South African perspective”, Prof. Solomon explored five challenges to academic political science in general and to South African political scientists in particular.

The challenges include the need to localise international relations theory with an emphasis on the emancipatory dimensions; exploring the nexus between technology and politics; incorporating political anthropology into mainstream political science syllabi; rising to the challenge of governing Africa’s cities; and the dangers of over-specialisation in an era that demands the use of a broader academic lens.

According to Prof. Solomon, political science has come a long way from those heady days in 1950 when Lasswell could confidently state that politics was about who gets what, when and how.

“Indeed, the world of 2012 scarcely resembles the world of 1950. Immanuel Wallerstein was correct in his assessment that the modern world system is coming to an end. As political scientists, we need to interrogate our existing knowledge constructs in relation to this rapidly changing reality. We need to indigenise international relations theory and emphasise creating an emancipatory and counter-hegemonic discourse.

We need to explore the nexus between technology and politics to deepen our democracy by empowering the margins in our societies. We need to embrace political anthropology as we strive to understand non-Western forms of governance. We need to use these understandings of traditional societies as we create hybrid forms of urban governance that stress inclusivity as we overcome the politics of identity and difference. We need to heed the call of De Tocqueville and create a new political science to understand the new times by supplementing disciplinary insights with those from other disciplines. In doing so, political science will once more regain its relevance to humanity in the twenty-first century,” Prof. Solomon said.
 

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