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01 October 2021 | Story Lunga Luthuli and Vicky Simpson | Photo Supplied
Anton Engelbrecht _ Farmovs researcher
Anton Engelbrecht, FARMOVS Bioanalysis Specialist.

“At FARMOVS, we have the opportunity to work with the world’s top pharmaceutical companies, where we form part of the evaluation of labelled and/or conjugated antigens and antibodies that are developed for accurate quantification of endogenous and pharmaceutical compounds. Alternatively, commercially available kits and reagents are also used for the same purpose if the sponsor cannot supply the customised antigens/antibodies. The developed assay methods are put through a rigorous validation assessment to confirm the selectivity, sensitivity, and robustness of the assay,” says Anton Engelbrecht, FARMOVS Bioanalysis Specialist. 

FARMOVS, affiliated to the University of the Free State and operating from the Bloemfontein Campus, is a leading clinical research organisation (CRO) with a unique advantage. As the only on-site ISO15189-accredited and GLP-certified pharmacokinetic laboratory on the African continent, with numerous successful inspections by leading international regulators, it offers the highest quality bioanalytical services in a variety of biological matrices for the development of pharmaceutical products.

Engelbrecht says: “The team of bioanalytical experts thrives on the excitement generated by new discoveries that lead to better treatment of a variety of physiological diseases.”

Advanced technology backed by 47 years of bioanalytical experience

The clinical research organisation prides itself on advanced technology, backed by 47 years of bioanalytical experience. It has developed more than 580 validated analytical methods that adhere to the International Council for Harmonisation and the US Food and Drug Administration (FDA) guidelines. FARMOVS’ analytical methods have been used in more than 3 000 pre-clinical and clinical trials, contributing to the manufacturing of pharmaceutical drugs that are now used by households across the globe.

At FARMOVS, Engelbrecht says, it is a “world filled with novel methods of analysis and subsequent technological integration that expands the horizons of clinical research forming an important part of the discovery and production of new life-saving medicines that is constantly improving the quality of life of people all over the world”.

Engelbrecht says: “New technology and innovation should be the building blocks of any laboratory, and among these are the three fastest sample production members of our Immunochemistry Laboratory team – the STARLet pipettors.”

“We chose the Microlab® STARLet apparatus by Hamilton, because of its ability to perform sample analysis in large quantities at a greater speed by means of robotic pipetting and robotic automated microplate reading, which is a semi-automated process.”

He shared his excitement about improvements in the field of immunoassay development for the purposes of pharmaceutical analysis. This involves the preparation of unique immunoanalytical reagents, analysis of new categories of compounds, methodology, and instrumentation. The most important examples in this field are the continuous development of bead-based immunoassays.

Staying competitive in the industry

Immunoassay methods, such as radioimmunoassay (RIA) and enzyme immunoassay (EIA), among others, are also used at FARMOVS to analyse macromolecules for clients. “The RIA method is used for the determination of several pharmaceutically important compounds in biological fluids. RIA requires a sample containing the antigen of interest, a complementary antibody, and a radiolabelled version of the antigen. To increase the selectivity of an assay, all samples are pre-treated to eliminate high molecular weight endogenous matrix components, including anti-drug antibodies,” explains Engelbrecht.

Although FARMOVS has adequate technology to provide market-related results, the plan is to expand the team to include a multiplex platform that is a sensitive, fully automated immunoassay platform with multiplexing and custom assay capability. “This will pave the way to use an even more sensitive method to quantify biomarkers in the fields of oncology, neurology, cardiology, inflammation, and infectious disease. We aim to remain competitive in our industry, so naturally we must recruit the brightest and most evolved to join the team,” he says.

News Archive

Two academics will be sorely missed
2013-04-02

  

Prof Andrew Marston and Prof Bannie Britz
Photo: Supplied
02 April 2013

The staff and students of the University of the Free State (UFS) are deeply saddened by the recent passing in Bloemfontein of two of the university’s most esteemed and renowned academics, Prof Bannie Britz and Prof Andrew Marston.

Prof Britz was the Head of the Department of Architecture from 1992 to 2000. He was renowned in his field, winning numerous prizes for Architecture, including the Gold Medal for Architecture from the South African Academy of Arts and Sciences.

“As professional architect and urban designer, Prof Britz was a much awarded architect who received numerous award of merit from the South African Institute of Architects for buildings erected in South Africa over the years,” said Martie Bitzer, Head of the Department of Architecture.

Apart from his acclaim elsewhere, Prof Britz also played a major role in the day-to-day activities of university’s staff and students. He was responsible for the design of the many walkways on campus and the refurbishment of the Main Building on the Bloemfontein Campus. For the many contributions in his field, Prof Britz was awarded an Honorary Doctorate by the UFS in 2007.

Prof Andrew Marston, a specialist in natural product chemistry and methods associated with the isolation and analysis of medically important chemicals from plants, was appointed from Geneva, Switzerland in 2009 under the UFS Strategic Cluster for Advanced Biomolecular Research.

He obtained a B-rating from the National Research Foundation (NRF) in 2011, and was consequently appointed as a senior professor in die UFS Senior Professor Programme. “He has made valuable contributions to the UFS in terms of teaching and postgraduate supervision, as well as research. In his short stay at the UFS, he already co-authored more than ten papers in international chemistry literature,” said Prof André Roodt, Head of the Department of Chemistry.

His research group was part of a multilateral agreement in the European Union (EU) with a number of African and three European universities. He obtained new research funding from the Seventh Framework Programme of the EU for the Building Sustainable Research Capacity on Plants for Better Public Health in Africa project, from the Norwegian Research Council for bioprospecting and the isolation and structure determination of compounds from plants and algae, and from the South African Rooibos Tea Council.

The memorial service for Prof Britz took place on Friday 5 April 2013 in the Berg-en-Dal Dutch Reformed Church in Bloemfontein. The service for Prof Marston took place in the Trinity Church, Charles Street, Bloemfontein.

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