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FARMOVS – 47 years of bioanalytical experience leads pre-clinical and clinical trials

01 October 2021 | Story Lunga Luthuli and Vicky Simpson | Photo Supplied

Anton Engelbrecht _ Farmovs researcher — Anton Engelbrecht, FARMOVS Bioanalysis Specialist.

“At FARMOVS, we have the opportunity to work with the world’s top pharmaceutical companies, where we form part of the evaluation of labelled and/or conjugated antigens and antibodies that are developed for accurate quantification of endogenous and pharmaceutical compounds. Alternatively, commercially available kits and reagents are also used for the same purpose if the sponsor cannot supply the customised antigens/antibodies. The developed assay methods are put through a rigorous validation assessment to confirm the selectivity, sensitivity, and robustness of the assay,” says Anton Engelbrecht, FARMOVS Bioanalysis Specialist.

FARMOVS, affiliated to the University of the Free State and operating from the Bloemfontein Campus, is a leading clinical research organisation (CRO) with a unique advantage. As the only on-site ISO15189-accredited and GLP-certified pharmacokinetic laboratory on the African continent, with numerous successful inspections by leading international regulators, it offers the highest quality bioanalytical services in a variety of biological matrices for the development of pharmaceutical products.

Engelbrecht says: “The team of bioanalytical experts thrives on the excitement generated by new discoveries that lead to better treatment of a variety of physiological diseases.”

Advanced technology backed by 47 years of bioanalytical experience

The clinical research organisation prides itself on advanced technology, backed by 47 years of bioanalytical experience. It has developed more than 580 validated analytical methods that adhere to the International Council for Harmonisation and the US Food and Drug Administration (FDA) guidelines. FARMOVS’ analytical methods have been used in more than 3 000 pre-clinical and clinical trials, contributing to the manufacturing of pharmaceutical drugs that are now used by households across the globe.

At FARMOVS, Engelbrecht says, it is a “world filled with novel methods of analysis and subsequent technological integration that expands the horizons of clinical research forming an important part of the discovery and production of new life-saving medicines that is constantly improving the quality of life of people all over the world”.

Engelbrecht says: “New technology and innovation should be the building blocks of any laboratory, and among these are the three fastest sample production members of our Immunochemistry Laboratory team – the STARLet pipettors.”

“We chose the Microlab® STARLet apparatus by Hamilton, because of its ability to perform sample analysis in large quantities at a greater speed by means of robotic pipetting and robotic automated microplate reading, which is a semi-automated process.”

He shared his excitement about improvements in the field of immunoassay development for the purposes of pharmaceutical analysis. This involves the preparation of unique immunoanalytical reagents, analysis of new categories of compounds, methodology, and instrumentation. The most important examples in this field are the continuous development of bead-based immunoassays.

Staying competitive in the industry

Immunoassay methods, such as radioimmunoassay (RIA) and enzyme immunoassay (EIA), among others, are also used at FARMOVS to analyse macromolecules for clients. “The RIA method is used for the determination of several pharmaceutically important compounds in biological fluids. RIA requires a sample containing the antigen of interest, a complementary antibody, and a radiolabelled version of the antigen. To increase the selectivity of an assay, all samples are pre-treated to eliminate high molecular weight endogenous matrix components, including anti-drug antibodies,” explains Engelbrecht.

Although FARMOVS has adequate technology to provide market-related results, the plan is to expand the team to include a multiplex platform that is a sensitive, fully automated immunoassay platform with multiplexing and custom assay capability. “This will pave the way to use an even more sensitive method to quantify biomarkers in the fields of oncology, neurology, cardiology, inflammation, and infectious disease. We aim to remain competitive in our industry, so naturally we must recruit the brightest and most evolved to join the team,” he says.

News Archive

Lots of inspiration at Autumn Graduation Ceremony

2013-04-18

Graduates celebrate the results of years of study at the graduation ceremony on the Bloemfontein Campus.
Photo: Hannes Pieterse
17 April 2013

Live streaming of ceremonies available from 16 April - 19 April 2013: http://www.ufs.ac.za/ufslivestreaming/

Joshua Johnson YouTube video

The university’s Autumn Graduation Ceremony got off to a vibrant start with energetic performances and inspiring messages for graduates.

Joshua Johnson, an American student who uses his talent for tap-dancing to fund his tertiary education, mesmerised the audience on the first of the four-day graduation ceremony with his story of hope and perseverance. The student from Penn State University travels five hours by bus to New York every weekend where he tap-dances on the subway trains to earn money for his tuition fees.

Delivering a keynote address, Joshua told graduates that, in order to achieve their goals, they have to understand and work diligently with the 24 hours they get to live daily. “Start with a bang and end with a bang,” he said, encouraging the audience in the nearly-packed Callie Human Centre to join him in a rhythmic tap-dancing beat.

“Don’t follow in the footsteps of someone else. Take the beat of life, but add your rhythm to it," his wise words resonating with the exhilarated graduates.

Joshua will be the guest speaker at the ceremonies on 16, 17 and 19 April 2013 and will deliver a dance item during each occasion.

Dr Khotso Mokhele, Chancellor of the University, echoed Joshua‘s message, telling graduates not to be discouraged by life’s difficulties.

“Take what you have learned over the last three or four years and use that knowledge to reach your goal,” he advised.

Prof Jonathan Jansen, Rector and Vice-Chancellor, encouraged them to continue to study. “To break the cycle of poverty, get an education, get a degree.” He told them that as graduates they are ten times more likely to get a job, with the odds rising as they continue their postgraduate studies.

Well-known radio host and Idols South Africa judge, Gareth Cliff, will be the guest speaker at two ceremonies on 18 April 2013. He will be joined by Vicus Visser, the South African YouTube singing sensation. Dubbed Bloemfontein’s Justin Bieber, Vicus and his brother Vincent will perform during these two ceremonies.

The programme for the respective ceremonies is:

Wednesday 17 April

09:30 Diplomas and certificates up to and including honours degrees in the Faculty of Education.
14:30 Diplomas and certificates up to and including honours degrees in the Faculties of Health Sciences, Law and Theology.

Thursday 18 April

09:30 Diplomas and certificates up to and including honours degrees in the Faculty of Natural and Agricultural Sciences: only Agricultural Sciences and Architecture.
14:30 Diplomas and certificates up to and including honours degrees in the Faculty of Natural and Agricultural Sciences: only Natural Sciences.

Friday 19 April

09:30 Diplomas and certificates up to and including honours degrees in the Faculty of Economic and Management Sciences: all diplomas and degrees in the Faculty, except BCom and BComHons.
14:30 Diplomas and certificates up to and including honours degrees in the Faculty of Economic and Management Sciences: only BCom and BComHons.

The Qwaqwa Campus’ graduation ceremony will take place on 8 June 2013. Diplomas/certificates up to and including doctorates will be awarded at this ceremony.

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