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Anton Engelbrecht _ Farmovs researcher
Anton Engelbrecht, FARMOVS Bioanalysis Specialist.

“At FARMOVS, we have the opportunity to work with the world’s top pharmaceutical companies, where we form part of the evaluation of labelled and/or conjugated antigens and antibodies that are developed for accurate quantification of endogenous and pharmaceutical compounds. Alternatively, commercially available kits and reagents are also used for the same purpose if the sponsor cannot supply the customised antigens/antibodies. The developed assay methods are put through a rigorous validation assessment to confirm the selectivity, sensitivity, and robustness of the assay,” says Anton Engelbrecht, FARMOVS Bioanalysis Specialist. 

FARMOVS, affiliated to the University of the Free State and operating from the Bloemfontein Campus, is a leading clinical research organisation (CRO) with a unique advantage. As the only on-site ISO15189-accredited and GLP-certified pharmacokinetic laboratory on the African continent, with numerous successful inspections by leading international regulators, it offers the highest quality bioanalytical services in a variety of biological matrices for the development of pharmaceutical products.

Engelbrecht says: “The team of bioanalytical experts thrives on the excitement generated by new discoveries that lead to better treatment of a variety of physiological diseases.”

Advanced technology backed by 47 years of bioanalytical experience

The clinical research organisation prides itself on advanced technology, backed by 47 years of bioanalytical experience. It has developed more than 580 validated analytical methods that adhere to the International Council for Harmonisation and the US Food and Drug Administration (FDA) guidelines. FARMOVS’ analytical methods have been used in more than 3 000 pre-clinical and clinical trials, contributing to the manufacturing of pharmaceutical drugs that are now used by households across the globe.

At FARMOVS, Engelbrecht says, it is a “world filled with novel methods of analysis and subsequent technological integration that expands the horizons of clinical research forming an important part of the discovery and production of new life-saving medicines that is constantly improving the quality of life of people all over the world”.

Engelbrecht says: “New technology and innovation should be the building blocks of any laboratory, and among these are the three fastest sample production members of our Immunochemistry Laboratory team – the STARLet pipettors.”

“We chose the Microlab® STARLet apparatus by Hamilton, because of its ability to perform sample analysis in large quantities at a greater speed by means of robotic pipetting and robotic automated microplate reading, which is a semi-automated process.”

He shared his excitement about improvements in the field of immunoassay development for the purposes of pharmaceutical analysis. This involves the preparation of unique immunoanalytical reagents, analysis of new categories of compounds, methodology, and instrumentation. The most important examples in this field are the continuous development of bead-based immunoassays.

Staying competitive in the industry

Immunoassay methods, such as radioimmunoassay (RIA) and enzyme immunoassay (EIA), among others, are also used at FARMOVS to analyse macromolecules for clients. “The RIA method is used for the determination of several pharmaceutically important compounds in biological fluids. RIA requires a sample containing the antigen of interest, a complementary antibody, and a radiolabelled version of the antigen. To increase the selectivity of an assay, all samples are pre-treated to eliminate high molecular weight endogenous matrix components, including anti-drug antibodies,” explains Engelbrecht.

Although FARMOVS has adequate technology to provide market-related results, the plan is to expand the team to include a multiplex platform that is a sensitive, fully automated immunoassay platform with multiplexing and custom assay capability. “This will pave the way to use an even more sensitive method to quantify biomarkers in the fields of oncology, neurology, cardiology, inflammation, and infectious disease. We aim to remain competitive in our industry, so naturally we must recruit the brightest and most evolved to join the team,” he says.

News Archive

Up to 60% of students do not have enough to eat
2013-11-15

 

15 November 2013

A report of the University of the Free State has revealed the shocking statistics that almost two-thirds of the students at the university don’t have enough money to buy food, and suffer from hunger during terms.

The study, conducted internally by the university’s Department of Nutrition and Dietetics, was a response to a growing international concern that students worldwide were not getting enough to eat. While studies were conducted in the USA and Australia, no similar research has been done in South Africa.

“There have been many studies on the impact of poor nutrition on school kids,” says Dr Louise van den Berg, Senior Lecturer in the Department of Nutrition and Dietetics, “but almost no research on university students. South Africa is, overall, a food-insecure country, and the university wanted to establish how widespread this problem is among our students.”

The reasons given by students invariably referred to a lack of money, as many students were also supporting families. Some students admitted they lacked the knowledge to feed themselves properly, some admitted to borrowing money to buy food, and some even admitted to stealing food to survive.

“This research has confirmed something we have suspected for a long time,” Dr van den Berg states.

A number of students disclosed that they were reluctant to resort to the university feeding scheme, as they were ashamed to admit they did not have money to buy food.

This study is the first of its kind in South Africa, and underlines the fact that tertiary students are particularly vulnerable when it comes to food security. Often a student has to juggle their studies with their role as breadwinner.

A tiny ray of hope to students who find themselves as food insecure, is the No Student Hungry Programme that offers a food bursary to qualifying students.

This programme, initially established by Prof Jonathan Jansen, UFS Vice-Chancellor and Rector, and now managed by Grace Jansen and Karen Buys, offers a small allowance of about R30 per day to hungry students with an average academic achievement of 60% and above. This criterion discourages entitlement thinking and builds a strong sense of responsibility on the part of those who benefit from the food bursary.

Melanie, a second-year Geography and Environmental Management student, as well as a single mother, is a beneficiary of the NSH Programme. “This bursary helps me to get a balanced meal every day. It is one less worry for me. I dream of completing my studies so that I can be independent and provide my son with the life he deserves.”

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