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01 October 2021 | Story Lunga Luthuli and Vicky Simpson | Photo Supplied
Anton Engelbrecht _ Farmovs researcher
Anton Engelbrecht, FARMOVS Bioanalysis Specialist.

“At FARMOVS, we have the opportunity to work with the world’s top pharmaceutical companies, where we form part of the evaluation of labelled and/or conjugated antigens and antibodies that are developed for accurate quantification of endogenous and pharmaceutical compounds. Alternatively, commercially available kits and reagents are also used for the same purpose if the sponsor cannot supply the customised antigens/antibodies. The developed assay methods are put through a rigorous validation assessment to confirm the selectivity, sensitivity, and robustness of the assay,” says Anton Engelbrecht, FARMOVS Bioanalysis Specialist. 

FARMOVS, affiliated to the University of the Free State and operating from the Bloemfontein Campus, is a leading clinical research organisation (CRO) with a unique advantage. As the only on-site ISO15189-accredited and GLP-certified pharmacokinetic laboratory on the African continent, with numerous successful inspections by leading international regulators, it offers the highest quality bioanalytical services in a variety of biological matrices for the development of pharmaceutical products.

Engelbrecht says: “The team of bioanalytical experts thrives on the excitement generated by new discoveries that lead to better treatment of a variety of physiological diseases.”

Advanced technology backed by 47 years of bioanalytical experience

The clinical research organisation prides itself on advanced technology, backed by 47 years of bioanalytical experience. It has developed more than 580 validated analytical methods that adhere to the International Council for Harmonisation and the US Food and Drug Administration (FDA) guidelines. FARMOVS’ analytical methods have been used in more than 3 000 pre-clinical and clinical trials, contributing to the manufacturing of pharmaceutical drugs that are now used by households across the globe.

At FARMOVS, Engelbrecht says, it is a “world filled with novel methods of analysis and subsequent technological integration that expands the horizons of clinical research forming an important part of the discovery and production of new life-saving medicines that is constantly improving the quality of life of people all over the world”.

Engelbrecht says: “New technology and innovation should be the building blocks of any laboratory, and among these are the three fastest sample production members of our Immunochemistry Laboratory team – the STARLet pipettors.”

“We chose the Microlab® STARLet apparatus by Hamilton, because of its ability to perform sample analysis in large quantities at a greater speed by means of robotic pipetting and robotic automated microplate reading, which is a semi-automated process.”

He shared his excitement about improvements in the field of immunoassay development for the purposes of pharmaceutical analysis. This involves the preparation of unique immunoanalytical reagents, analysis of new categories of compounds, methodology, and instrumentation. The most important examples in this field are the continuous development of bead-based immunoassays.

Staying competitive in the industry

Immunoassay methods, such as radioimmunoassay (RIA) and enzyme immunoassay (EIA), among others, are also used at FARMOVS to analyse macromolecules for clients. “The RIA method is used for the determination of several pharmaceutically important compounds in biological fluids. RIA requires a sample containing the antigen of interest, a complementary antibody, and a radiolabelled version of the antigen. To increase the selectivity of an assay, all samples are pre-treated to eliminate high molecular weight endogenous matrix components, including anti-drug antibodies,” explains Engelbrecht.

Although FARMOVS has adequate technology to provide market-related results, the plan is to expand the team to include a multiplex platform that is a sensitive, fully automated immunoassay platform with multiplexing and custom assay capability. “This will pave the way to use an even more sensitive method to quantify biomarkers in the fields of oncology, neurology, cardiology, inflammation, and infectious disease. We aim to remain competitive in our industry, so naturally we must recruit the brightest and most evolved to join the team,” he says.

News Archive

In her inaugural lecture, Prof Helene Strauss explores symbols that reflect our history
2014-02-18

 

Prof Helene Strauss
The burning tyre – image of promise and disappointment
Photo: Stephen Collett

Prof Helene Strauss did not disappoint in her highly-anticipated inaugural lecture “The Spectacles of Promise and Disappointment: Political Emotion and Quotidian Aesthetics in Post-transitional South Africa”. She posed some very challenging ideas on the promises and disappointments that arouse from apartheid. Prof Strauss pointed to the fact that “… a promise must promise to be kept; that is, not to remain spiritual or abstract, but to produce events, new effective forms of action, practice, organisation, and so forth.”

She underscored the message of her lecture by making use of the image of a burning tyre – a symbol commonly associated with apartheid. This act of ‘necklacing’ is closely connected to the violence and protests of that era. Prof Strauss used this image to represent an array of social concerns: global mass protest, modernity and mobility, waste economies and waste management, environmental destruction, as well as poverty and resistance in varied formats.

Some of South Africa’s greatest artists have used the burning tyre in their work, particularlyBerni Searle and Zanele Muhloi. Not only does it trigger the shadow of the damaging past, but “more recently, it has come to figure also in the spectacles of promise and disappointment that have marked the country’s transitional and post-transitional periods,” Prof Strauss remarked.

Prof Strauss focuses her research on these symbolisms in our history because of “the questions that they raise about the emotional cultures produced in the aftermath of apartheid and for the unique contribution that they make to current debates on political and aesthetic activism.”Her passion for this subject comes from the “affective or emotional legacies of various forms of structural inequality, an interest that owes a sizeable debt to postcolonial, queer and feminist critical theory and creative work of the past hundred or so years.”

Prof Strauss accepted a position at the University of the Free Sate in 2011 and currently works in the Department of English. She is part of the Vice-Chancellor’s Prestige Scholars Programme and holds a PhD from the University of Western Ontario. Previously, she held the position of Assistant Professor in the Department of English and Cultural Studies at McMaster University in Canada, where she resided for 11 years.

Among the guests were Prof Jonathan Jansen, Profs Botes and Witthuhn, lecturers in the Department of English, members of the Faculty of the Humanities, students and some of Prof Strauss’ colleagues from Canada.

 

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