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FARMOVS – 47 years of bioanalytical experience leads pre-clinical and clinical trials

01 October 2021 | Story Lunga Luthuli and Vicky Simpson | Photo Supplied

Anton Engelbrecht _ Farmovs researcher — Anton Engelbrecht, FARMOVS Bioanalysis Specialist.

“At FARMOVS, we have the opportunity to work with the world’s top pharmaceutical companies, where we form part of the evaluation of labelled and/or conjugated antigens and antibodies that are developed for accurate quantification of endogenous and pharmaceutical compounds. Alternatively, commercially available kits and reagents are also used for the same purpose if the sponsor cannot supply the customised antigens/antibodies. The developed assay methods are put through a rigorous validation assessment to confirm the selectivity, sensitivity, and robustness of the assay,” says Anton Engelbrecht, FARMOVS Bioanalysis Specialist.

FARMOVS, affiliated to the University of the Free State and operating from the Bloemfontein Campus, is a leading clinical research organisation (CRO) with a unique advantage. As the only on-site ISO15189-accredited and GLP-certified pharmacokinetic laboratory on the African continent, with numerous successful inspections by leading international regulators, it offers the highest quality bioanalytical services in a variety of biological matrices for the development of pharmaceutical products.

Engelbrecht says: “The team of bioanalytical experts thrives on the excitement generated by new discoveries that lead to better treatment of a variety of physiological diseases.”

Advanced technology backed by 47 years of bioanalytical experience

The clinical research organisation prides itself on advanced technology, backed by 47 years of bioanalytical experience. It has developed more than 580 validated analytical methods that adhere to the International Council for Harmonisation and the US Food and Drug Administration (FDA) guidelines. FARMOVS’ analytical methods have been used in more than 3 000 pre-clinical and clinical trials, contributing to the manufacturing of pharmaceutical drugs that are now used by households across the globe.

At FARMOVS, Engelbrecht says, it is a “world filled with novel methods of analysis and subsequent technological integration that expands the horizons of clinical research forming an important part of the discovery and production of new life-saving medicines that is constantly improving the quality of life of people all over the world”.

Engelbrecht says: “New technology and innovation should be the building blocks of any laboratory, and among these are the three fastest sample production members of our Immunochemistry Laboratory team – the STARLet pipettors.”

“We chose the Microlab® STARLet apparatus by Hamilton, because of its ability to perform sample analysis in large quantities at a greater speed by means of robotic pipetting and robotic automated microplate reading, which is a semi-automated process.”

He shared his excitement about improvements in the field of immunoassay development for the purposes of pharmaceutical analysis. This involves the preparation of unique immunoanalytical reagents, analysis of new categories of compounds, methodology, and instrumentation. The most important examples in this field are the continuous development of bead-based immunoassays.

Staying competitive in the industry

Immunoassay methods, such as radioimmunoassay (RIA) and enzyme immunoassay (EIA), among others, are also used at FARMOVS to analyse macromolecules for clients. “The RIA method is used for the determination of several pharmaceutically important compounds in biological fluids. RIA requires a sample containing the antigen of interest, a complementary antibody, and a radiolabelled version of the antigen. To increase the selectivity of an assay, all samples are pre-treated to eliminate high molecular weight endogenous matrix components, including anti-drug antibodies,” explains Engelbrecht.

Although FARMOVS has adequate technology to provide market-related results, the plan is to expand the team to include a multiplex platform that is a sensitive, fully automated immunoassay platform with multiplexing and custom assay capability. “This will pave the way to use an even more sensitive method to quantify biomarkers in the fields of oncology, neurology, cardiology, inflammation, and infectious disease. We aim to remain competitive in our industry, so naturally we must recruit the brightest and most evolved to join the team,” he says.

News Archive

International Year of Crystallography attracts science experts from across the globe

2014-10-13

Video: Discover what Chrystallopgraphy can do for you
Video: Celebrating Crystallography: An Animated Adventure

Summit programme

The third world summit in the International Year of Crystallography (in Africa) will be hosted by the UFS Department of Chemistry here on the Bloemfontein Campus. Prof André Roodt, Head of the Department of Chemistry, was elected as the President of the European Crystallographic Association in 2012. Earlier this year he unveiled the Max von Laue 'Plaque' in Posnan, Poland.

The Pan-African Meeting of the International Year of Crystallography consists of a congress and summit. The details are as follows:

Congress
12–15 October 2014
CR Swart Senate Hall, UFS Bloemfontein Campus

Summit
15–17 October 2014
CR Swart Senate Hall, UFS Bloemfontein Campus
Summit opening: Wednesday 15 October 2014 at 14:00 in the CR Swart Senate Hall

This event will be opened and attended by:
•   the UFS Rector and Vice-Rector – Profs Jonathan Jansen and Corli Witthuhn;
•   the acting Director-General of the Department of Science and Technology – Dr Thomas Auf der Heyde;
•   the acting CEO of the National Research Foundation – Dr Gansen Pillay;
•   the UNESCO Vice-Director for Science Extension – Dr Jean-Paul Ngome-Abiaga (Paris, France);
•   the representative of the Executive Committee for the International Union of Crystallography (IUCr) – Prof Santiago Garcia-Granda (Oviedo: Spain);
•   the marketing director of the IUCr – Prof Michele Zema (Pavia, Italy);
•   the President of the European Crystallographic Association (ECA) – Prof André Roodt, who will officially open the summit on Wednesday 15 October 2014 from 14:00–15:30.

Presenters from across Africa and Europe will deliver papers at this event which will be attended by more than 100 delegates from twenty-plus countries, including Spain, France, Italy, Croatia, Germany, Russia and India.

Numerous crystallographic research areas will be covered. This includes:
•   powder diffraction,
•   small molecule crystallography,
•   biological crystallography,
•   industrial crystallography,
•   surface crystallography,
as well as techniques such as
•   electron microscopy and
•   synchrotron work.

“At this event we hope to establish an African Crystallographic Association,” said Prof Roodt.

The United Nations declared 2014 as the International Year of Crystallography. It was recently officially opened at the UNESCO headquarters in Paris, France, by the Secretary General of the UN, Ban Ki-moon.

The International Year of Crystallography celebrates the centennial of the work of Max von Laue and the father and son, William Henry and William Laurence Bragg. More generally, it celebrates what crystallography can do for humanity – which proves to be a significant amount.

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