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01 October 2021 | Story Lunga Luthuli and Vicky Simpson | Photo Supplied
Anton Engelbrecht _ Farmovs researcher
Anton Engelbrecht, FARMOVS Bioanalysis Specialist.

“At FARMOVS, we have the opportunity to work with the world’s top pharmaceutical companies, where we form part of the evaluation of labelled and/or conjugated antigens and antibodies that are developed for accurate quantification of endogenous and pharmaceutical compounds. Alternatively, commercially available kits and reagents are also used for the same purpose if the sponsor cannot supply the customised antigens/antibodies. The developed assay methods are put through a rigorous validation assessment to confirm the selectivity, sensitivity, and robustness of the assay,” says Anton Engelbrecht, FARMOVS Bioanalysis Specialist. 

FARMOVS, affiliated to the University of the Free State and operating from the Bloemfontein Campus, is a leading clinical research organisation (CRO) with a unique advantage. As the only on-site ISO15189-accredited and GLP-certified pharmacokinetic laboratory on the African continent, with numerous successful inspections by leading international regulators, it offers the highest quality bioanalytical services in a variety of biological matrices for the development of pharmaceutical products.

Engelbrecht says: “The team of bioanalytical experts thrives on the excitement generated by new discoveries that lead to better treatment of a variety of physiological diseases.”

Advanced technology backed by 47 years of bioanalytical experience

The clinical research organisation prides itself on advanced technology, backed by 47 years of bioanalytical experience. It has developed more than 580 validated analytical methods that adhere to the International Council for Harmonisation and the US Food and Drug Administration (FDA) guidelines. FARMOVS’ analytical methods have been used in more than 3 000 pre-clinical and clinical trials, contributing to the manufacturing of pharmaceutical drugs that are now used by households across the globe.

At FARMOVS, Engelbrecht says, it is a “world filled with novel methods of analysis and subsequent technological integration that expands the horizons of clinical research forming an important part of the discovery and production of new life-saving medicines that is constantly improving the quality of life of people all over the world”.

Engelbrecht says: “New technology and innovation should be the building blocks of any laboratory, and among these are the three fastest sample production members of our Immunochemistry Laboratory team – the STARLet pipettors.”

“We chose the Microlab® STARLet apparatus by Hamilton, because of its ability to perform sample analysis in large quantities at a greater speed by means of robotic pipetting and robotic automated microplate reading, which is a semi-automated process.”

He shared his excitement about improvements in the field of immunoassay development for the purposes of pharmaceutical analysis. This involves the preparation of unique immunoanalytical reagents, analysis of new categories of compounds, methodology, and instrumentation. The most important examples in this field are the continuous development of bead-based immunoassays.

Staying competitive in the industry

Immunoassay methods, such as radioimmunoassay (RIA) and enzyme immunoassay (EIA), among others, are also used at FARMOVS to analyse macromolecules for clients. “The RIA method is used for the determination of several pharmaceutically important compounds in biological fluids. RIA requires a sample containing the antigen of interest, a complementary antibody, and a radiolabelled version of the antigen. To increase the selectivity of an assay, all samples are pre-treated to eliminate high molecular weight endogenous matrix components, including anti-drug antibodies,” explains Engelbrecht.

Although FARMOVS has adequate technology to provide market-related results, the plan is to expand the team to include a multiplex platform that is a sensitive, fully automated immunoassay platform with multiplexing and custom assay capability. “This will pave the way to use an even more sensitive method to quantify biomarkers in the fields of oncology, neurology, cardiology, inflammation, and infectious disease. We aim to remain competitive in our industry, so naturally we must recruit the brightest and most evolved to join the team,” he says.

News Archive

UFS Department of Computer Science and Informatics motivates programming success among learners
2015-04-23

From Sentraal High School are from the left: Albert Dreyer (full marks, Grade 9); Corlé van der Walt (full marks, Grade 10); Janco Venter (full marks, Grade 10); Soné du Pisanie (full marks, Grade 10) en Handré Venter (Grade 9).

A group of learners from the Free State, who are taught at and by the University of the Free State’s Department of Computer Science and Informatics (under the Python project), came first in the Talent Search round of the South African Computer Olympiad (SACO).

According to Dr Anelize van Biljon, senior lecturer in the Department of Computer Science and Informatics, the Olympiad is presented in three main rounds: the Talent Search, the Application Olympiad, and the Programming Olympiad.

At the UFS’s Department of Computer Science and Informatics’ Python project, pupils from various schools in Bloemfontein attend programming classes where they are taught by staff and students of the department. These students are benefitted by the opportunity to transfer their knowledge to others. All the classes are free of charge.

Anelize explains: “The name was chosen because we use the Python programming language. It is a language with considerable appeal – not one of the fastest – which can be learnt relatively quickly, and which conforms to SACO requirements. The purpose of this programming is to implement algorithms (the learner is given a problem, makes a plan to solve it, and does the necessary programming). Thus, it is not about the looks of the programme, but about its effectiveness and speed.”
Anelize is the initialiser and co-ordinator of the Python project. "I started this project in 2010 in the Department of Computer Science and Informatics for learners from Grades 6 to 12 to encourage them to take the subject. These classes exposed them to something more than school work. I enjoy this kind of competitions and am also very involved with Maths Olympiads.

Achievements such as these are good advertisements for the Department of Computer Science and Informatics,” she said.

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