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FARMOVS – 47 years of bioanalytical experience leads pre-clinical and clinical trials

01 October 2021 | Story Lunga Luthuli and Vicky Simpson | Photo Supplied

Anton Engelbrecht _ Farmovs researcher — Anton Engelbrecht, FARMOVS Bioanalysis Specialist.

“At FARMOVS, we have the opportunity to work with the world’s top pharmaceutical companies, where we form part of the evaluation of labelled and/or conjugated antigens and antibodies that are developed for accurate quantification of endogenous and pharmaceutical compounds. Alternatively, commercially available kits and reagents are also used for the same purpose if the sponsor cannot supply the customised antigens/antibodies. The developed assay methods are put through a rigorous validation assessment to confirm the selectivity, sensitivity, and robustness of the assay,” says Anton Engelbrecht, FARMOVS Bioanalysis Specialist.

FARMOVS, affiliated to the University of the Free State and operating from the Bloemfontein Campus, is a leading clinical research organisation (CRO) with a unique advantage. As the only on-site ISO15189-accredited and GLP-certified pharmacokinetic laboratory on the African continent, with numerous successful inspections by leading international regulators, it offers the highest quality bioanalytical services in a variety of biological matrices for the development of pharmaceutical products.

Engelbrecht says: “The team of bioanalytical experts thrives on the excitement generated by new discoveries that lead to better treatment of a variety of physiological diseases.”

Advanced technology backed by 47 years of bioanalytical experience

The clinical research organisation prides itself on advanced technology, backed by 47 years of bioanalytical experience. It has developed more than 580 validated analytical methods that adhere to the International Council for Harmonisation and the US Food and Drug Administration (FDA) guidelines. FARMOVS’ analytical methods have been used in more than 3 000 pre-clinical and clinical trials, contributing to the manufacturing of pharmaceutical drugs that are now used by households across the globe.

At FARMOVS, Engelbrecht says, it is a “world filled with novel methods of analysis and subsequent technological integration that expands the horizons of clinical research forming an important part of the discovery and production of new life-saving medicines that is constantly improving the quality of life of people all over the world”.

Engelbrecht says: “New technology and innovation should be the building blocks of any laboratory, and among these are the three fastest sample production members of our Immunochemistry Laboratory team – the STARLet pipettors.”

“We chose the Microlab® STARLet apparatus by Hamilton, because of its ability to perform sample analysis in large quantities at a greater speed by means of robotic pipetting and robotic automated microplate reading, which is a semi-automated process.”

He shared his excitement about improvements in the field of immunoassay development for the purposes of pharmaceutical analysis. This involves the preparation of unique immunoanalytical reagents, analysis of new categories of compounds, methodology, and instrumentation. The most important examples in this field are the continuous development of bead-based immunoassays.

Staying competitive in the industry

Immunoassay methods, such as radioimmunoassay (RIA) and enzyme immunoassay (EIA), among others, are also used at FARMOVS to analyse macromolecules for clients. “The RIA method is used for the determination of several pharmaceutically important compounds in biological fluids. RIA requires a sample containing the antigen of interest, a complementary antibody, and a radiolabelled version of the antigen. To increase the selectivity of an assay, all samples are pre-treated to eliminate high molecular weight endogenous matrix components, including anti-drug antibodies,” explains Engelbrecht.

Although FARMOVS has adequate technology to provide market-related results, the plan is to expand the team to include a multiplex platform that is a sensitive, fully automated immunoassay platform with multiplexing and custom assay capability. “This will pave the way to use an even more sensitive method to quantify biomarkers in the fields of oncology, neurology, cardiology, inflammation, and infectious disease. We aim to remain competitive in our industry, so naturally we must recruit the brightest and most evolved to join the team,” he says.

News Archive

Meet the person behind the title – your new FaceOfFacebook

2015-04-29

Kovsies #FaceOfFacebook was born three years ago out of a need to engage with students, and become a virtual friend. Auditions are held every year to choose the new ‘face’ representing the UFS on Facebook. The successful candidate holds the title as #FaceOfFacebook for the next 12 months, attending events, and filming short video clips to post on our Facebook page.

The votes have been counted, and we have a winner. After much excitement and a close contest, Nompumelelo Maseko (whose name, fittingly, means ‘success’) emerged victorious from the top six contestants selected by our panel of judges. We sat down with the soft-spoken Mpumi – as her friends call her – to get a sense of the person who will be our ambassador for the next year.

What is your field of study, and how far along are you?

I am studying for a BSc degree in Genetics, and I’m currently in my second year. I have a particular interest in the forensic sciences, which fascinate me!

Are you originally from Bloemfontein?

No, I am originally from Pretoria.

How is it that you ended up here, studying at the UFS?

Before leaving school, I applied to various universities, but my desires and ambitions brought me here.

How do you find your residence?

Akasia ladies are big on sisterhood, very supportive. Res life is very enjoyable.

What do you hope to accomplish during your term as the #FaceOfFacebook?

I would like to help people become aware of what is taking place on campus. There are many opportunities to be more engaged with what is happening at the varsity. For instance, there are still many people who don’t really know what the #FaceOfFacebook is, and I would like to help inform them about it.

What is your motivation in your studies, in taking part in this contest, and in life?

I am intrigued by the function of life forms, the differences that exist at a cellular level.
For this competition, I fed off my love of people, even though I am shy. I also enjoy presenting.

I have my parents to thank as my motivation, as well as meeting and engaging with people. I find that I achieve a broader perspective when I don’t restrict myself to my own opinions, but strive to be open to differing views.

Nompumelelo will be appearing in one of her first Facebook videos shortly, so be sure to keep an eye on our Facebook page.

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