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01 October 2021 | Story Lunga Luthuli and Vicky Simpson | Photo Supplied
Anton Engelbrecht _ Farmovs researcher
Anton Engelbrecht, FARMOVS Bioanalysis Specialist.

“At FARMOVS, we have the opportunity to work with the world’s top pharmaceutical companies, where we form part of the evaluation of labelled and/or conjugated antigens and antibodies that are developed for accurate quantification of endogenous and pharmaceutical compounds. Alternatively, commercially available kits and reagents are also used for the same purpose if the sponsor cannot supply the customised antigens/antibodies. The developed assay methods are put through a rigorous validation assessment to confirm the selectivity, sensitivity, and robustness of the assay,” says Anton Engelbrecht, FARMOVS Bioanalysis Specialist. 

FARMOVS, affiliated to the University of the Free State and operating from the Bloemfontein Campus, is a leading clinical research organisation (CRO) with a unique advantage. As the only on-site ISO15189-accredited and GLP-certified pharmacokinetic laboratory on the African continent, with numerous successful inspections by leading international regulators, it offers the highest quality bioanalytical services in a variety of biological matrices for the development of pharmaceutical products.

Engelbrecht says: “The team of bioanalytical experts thrives on the excitement generated by new discoveries that lead to better treatment of a variety of physiological diseases.”

Advanced technology backed by 47 years of bioanalytical experience

The clinical research organisation prides itself on advanced technology, backed by 47 years of bioanalytical experience. It has developed more than 580 validated analytical methods that adhere to the International Council for Harmonisation and the US Food and Drug Administration (FDA) guidelines. FARMOVS’ analytical methods have been used in more than 3 000 pre-clinical and clinical trials, contributing to the manufacturing of pharmaceutical drugs that are now used by households across the globe.

At FARMOVS, Engelbrecht says, it is a “world filled with novel methods of analysis and subsequent technological integration that expands the horizons of clinical research forming an important part of the discovery and production of new life-saving medicines that is constantly improving the quality of life of people all over the world”.

Engelbrecht says: “New technology and innovation should be the building blocks of any laboratory, and among these are the three fastest sample production members of our Immunochemistry Laboratory team – the STARLet pipettors.”

“We chose the Microlab® STARLet apparatus by Hamilton, because of its ability to perform sample analysis in large quantities at a greater speed by means of robotic pipetting and robotic automated microplate reading, which is a semi-automated process.”

He shared his excitement about improvements in the field of immunoassay development for the purposes of pharmaceutical analysis. This involves the preparation of unique immunoanalytical reagents, analysis of new categories of compounds, methodology, and instrumentation. The most important examples in this field are the continuous development of bead-based immunoassays.

Staying competitive in the industry

Immunoassay methods, such as radioimmunoassay (RIA) and enzyme immunoassay (EIA), among others, are also used at FARMOVS to analyse macromolecules for clients. “The RIA method is used for the determination of several pharmaceutically important compounds in biological fluids. RIA requires a sample containing the antigen of interest, a complementary antibody, and a radiolabelled version of the antigen. To increase the selectivity of an assay, all samples are pre-treated to eliminate high molecular weight endogenous matrix components, including anti-drug antibodies,” explains Engelbrecht.

Although FARMOVS has adequate technology to provide market-related results, the plan is to expand the team to include a multiplex platform that is a sensitive, fully automated immunoassay platform with multiplexing and custom assay capability. “This will pave the way to use an even more sensitive method to quantify biomarkers in the fields of oncology, neurology, cardiology, inflammation, and infectious disease. We aim to remain competitive in our industry, so naturally we must recruit the brightest and most evolved to join the team,” he says.

News Archive

UFS hosts first SA Digital Sky Academy at the Naval Hill Planetarium
2015-10-02


From the left are: Prof Neil Heideman
(Dean: Faculty of Natural and Agricultural Sciences, UFS),
Jack White (Director: Sky-Skan Oceania),
Dr Michelle Cluver (Department of Astronomy, University of the Western Cape),
Martin Ratcliffe (Director: Professional Development, Sky-Skan).
Photo: Mart-Mari Duvenhage

South Africa hosts some of the world’s largest telescopes, and won the bid to co-host the SKA recently. So it’s not surprising that there is unprecedented interest in Astronomy in our country. Astronomy is seen as a gateway subject that attracts people to the sciences, while planetariums help to make Astronomy accessible to millions of people.  Digital planetariums are especially powerful teaching tools because they are versatile, offer an immersive experience, and explain and illustrate three-dimensional concepts effectively.  On the other hand, scientists, are eager to exploit a digital planetarium’s potential to represent and explore data visually, whether the data relate to medicine, astronomy, chemistry, the environment, or other fields of research.

The four-day ‘Digital Sky Academy’ (DSA) presented at the Naval Hill Planetarium in Bloemfontein from 18 - 22 September 2015 was an opportunity to offer training and first-hand experience of digital planetarium technology to representatives from other centres in South Africa. The Department of Physics at the University of the Free State (UFS) was the host of this event.

The Department of Science and Technology has designated the Naval Hill Planetarium as the South African hub for the training of digital planetarium presenters and operators. In addition to attracting interest from scientists and future planetarium operators and presenters, the DSA workshop provided an invaluable opportunity for our presenters to hone their skills.

A number of experienced and distinguished people attended the workshop. Among them was Dr Mark SubbaRao from Chicago in the United States, who shared information on data visualisation techniques used in the Adler Planetarium. Jack White, Director of Sky-Skan, one of the few companies that provide digital technology for planetariums throughout the world, coordinated the event in partnership with Prof Matie Hoffman from the Department of Physics at the UFS.

Jack travelled from Melbourne in Australia to oversee the workshop. Two Sky-Skan colleagues from the United States, Martin Weiss and Martin Ratcliffe, were on hand to share their expertise on digital planetarium hardware and software. The workshop programme included Skype conference calls with other US-based planetarium experts. Amongst the delegates to the DSA representatives from the SKA, the Iziko Museum, and five South Africa universities. They were here to gain experience, explore the capacity of the digital facility, and share ideas on future collaboration.

During the workshop, a public lecture was held on 19 September. Dr Michelle Cluver from the University of the Western Cape gave a presentation entitled, ‘More than the eye can see: the significance of infrared light in Astronomy.’

 

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