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01 October 2021 | Story Lunga Luthuli and Vicky Simpson | Photo Supplied
Anton Engelbrecht _ Farmovs researcher
Anton Engelbrecht, FARMOVS Bioanalysis Specialist.

“At FARMOVS, we have the opportunity to work with the world’s top pharmaceutical companies, where we form part of the evaluation of labelled and/or conjugated antigens and antibodies that are developed for accurate quantification of endogenous and pharmaceutical compounds. Alternatively, commercially available kits and reagents are also used for the same purpose if the sponsor cannot supply the customised antigens/antibodies. The developed assay methods are put through a rigorous validation assessment to confirm the selectivity, sensitivity, and robustness of the assay,” says Anton Engelbrecht, FARMOVS Bioanalysis Specialist. 

FARMOVS, affiliated to the University of the Free State and operating from the Bloemfontein Campus, is a leading clinical research organisation (CRO) with a unique advantage. As the only on-site ISO15189-accredited and GLP-certified pharmacokinetic laboratory on the African continent, with numerous successful inspections by leading international regulators, it offers the highest quality bioanalytical services in a variety of biological matrices for the development of pharmaceutical products.

Engelbrecht says: “The team of bioanalytical experts thrives on the excitement generated by new discoveries that lead to better treatment of a variety of physiological diseases.”

Advanced technology backed by 47 years of bioanalytical experience

The clinical research organisation prides itself on advanced technology, backed by 47 years of bioanalytical experience. It has developed more than 580 validated analytical methods that adhere to the International Council for Harmonisation and the US Food and Drug Administration (FDA) guidelines. FARMOVS’ analytical methods have been used in more than 3 000 pre-clinical and clinical trials, contributing to the manufacturing of pharmaceutical drugs that are now used by households across the globe.

At FARMOVS, Engelbrecht says, it is a “world filled with novel methods of analysis and subsequent technological integration that expands the horizons of clinical research forming an important part of the discovery and production of new life-saving medicines that is constantly improving the quality of life of people all over the world”.

Engelbrecht says: “New technology and innovation should be the building blocks of any laboratory, and among these are the three fastest sample production members of our Immunochemistry Laboratory team – the STARLet pipettors.”

“We chose the Microlab® STARLet apparatus by Hamilton, because of its ability to perform sample analysis in large quantities at a greater speed by means of robotic pipetting and robotic automated microplate reading, which is a semi-automated process.”

He shared his excitement about improvements in the field of immunoassay development for the purposes of pharmaceutical analysis. This involves the preparation of unique immunoanalytical reagents, analysis of new categories of compounds, methodology, and instrumentation. The most important examples in this field are the continuous development of bead-based immunoassays.

Staying competitive in the industry

Immunoassay methods, such as radioimmunoassay (RIA) and enzyme immunoassay (EIA), among others, are also used at FARMOVS to analyse macromolecules for clients. “The RIA method is used for the determination of several pharmaceutically important compounds in biological fluids. RIA requires a sample containing the antigen of interest, a complementary antibody, and a radiolabelled version of the antigen. To increase the selectivity of an assay, all samples are pre-treated to eliminate high molecular weight endogenous matrix components, including anti-drug antibodies,” explains Engelbrecht.

Although FARMOVS has adequate technology to provide market-related results, the plan is to expand the team to include a multiplex platform that is a sensitive, fully automated immunoassay platform with multiplexing and custom assay capability. “This will pave the way to use an even more sensitive method to quantify biomarkers in the fields of oncology, neurology, cardiology, inflammation, and infectious disease. We aim to remain competitive in our industry, so naturally we must recruit the brightest and most evolved to join the team,” he says.

News Archive

It takes a village to raise a child
2016-06-13

Description: Valentino_Student Bursary Fund Campaign Tags: Valentino_Student Bursary Fund Campaign

Valentino Ndaba
Photo: Sonia Small

(Click on CC for subtitles)

Video
Student Bursary Fund Campaign booklet (pdf)
Donate
Student Bursary Fund Campaign launched: #FundAFuture and make a difference
Motho ke motho ka batho. A person is a person through others

Want to make a difference in the world? Here is how

South Africa has one of the most spectacular coastlines in the world. Take the ribbon of golden beaches sweeping along the shores of KwaZulu-Natal, for instance. But just beyond the kiteboards dappling the ocean and fields of swaying sugarcane lies one of the largest informal settlements in the province: Amaoti. A place where barefoot children are skipping alongside poverty, and violent crime incinerates hope.

Nonetheless, that place could not keep Valentino Ndaba from graduating at the University of the Free State (UFS), and setting her sails for post-graduate studies.

A village
It takes a village to raise a child. This African proverb ripples across Valentino’s life story. “My gran always used to say education is your eternal bread. She still says it to this day. She has always instilled in me the importance of education,” Valentino smiles. Her grandmother has been but one of several champions in Valentino’s life.

Maalthee Dayaram – a teacher at Brookdale Secondary School that Valentino attended – noticed a budding talent in the young girl’s writing. With dedicated attention and ceaseless encouragement, Mrs Dayaram helped pave the way for this young writer. “You might be talented and have potential, but having someone actually believe in you and tell you that you have potential makes such a difference,” Valentino says. “I fell in love with writing, and had an idea that writing might be my future.” Dire economic circumstances threatened to snuff out any sparks of hope from that fragile future, though.

Aided by Lungisani Indlela (a non-profit organisation that provides children in the Amaoti area with school fees, uniforms, shoes, etc), Valentino clung to faith in the power of education. With unwavering single-mindedness, she consistently earned top grades.

Description: Valentino Ndaba 2 Tags: Valentino Ndaba 2

Photo: Sonia Small

Not if, but when
“Dreaming of my future, my gran would always say to me, ‘when you go to university’ or ‘when you have graduated’, this and that will follow.” Her gran’s words proved to be prophetic. As the final matric results were published in early January 2012, Valentino received a phone call that would change her life irrevocably.

That call came from the well-known South African humanitarian, Tich Smith. “Would you be willing to go to university in another province?” Smith asked. Never having travelled beyond her immediate surroundings, Valentino’s brave answer was: “Yes.”

A few days later, she walked onto the Bloemfontein Campus of the UFS.

Changing futures

Valentino proceeded to obtain a BA degree in Media Studies and Journalism in 2014. She has now set her sights on an honours degree, and envisions pursuing a Master’s degree in creative writing overseas.

“Without the support I received, I would have been stuck without a future,” she says. “University has shaped me into a better version of myself. I’ve grown intellectually, spiritually, and emotionally.”

You can bring about the same change for other students in need. By contributing to the UFS Student Bursary Fund Campaign, you can change the future not only of individuals, but of communities and of our country as well.

The impact of your financial support reaches far beyond its monetary value. It pulls families from poverty. It sends forth experts and visionaries into the world. It sets in motion a culture of giving.

Visit our Giving page for ways to contribute.

 

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