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22 October 2021 | Story Dr Nitha Ramnath | Photo Rhona Klopper
Donating masks to Rekopane Primary School, were from the left: Alfi Moolman (UFS Directorate: Community Engagement), Sonja Venter-Botes (Bloemshelter), Tina Moleko (Rankwe Primary School), and Michelle Engelbrecht (UFS Centre for Health Systems Research and Development).


The Centre for Health Systems Research and Development (CHSR&D) at the University of the Free State (UFS) recently donated 500 masks to Rekopane Primary School in Botshabelo. This initiative was part of its pledge to donate 100 cloth masks to a previously disadvantaged primary school for every 1 000 of the first 5 000 completed questionnaires that formed part of a study survey examining people’s understanding of information about COVID-19 vaccines. The results of the study will be shared with stakeholders who are responsible for providing information about COVID-19 vaccinations.

It is known that a large number of people globally and in South Africa prefer not to be vaccinated. “There are many reasons for this, and we would like to find out where people are getting information about the COVID-19 vaccination, and whether they are able to understand this information, so that they can make an informed choice about getting vaccinated. We did this by asking people about their own health and COVID-19, where they have heard about the vaccine, if they understood this information, and whether they have had/would have the vaccine or not, as well as the reasons for this,” said Prof Michelle Engelbrecht, Director of CHSR&D. 

While following guidelines such as wearing masks, sanitising hands, and social distancing are important to prevent the spread of COVID-19, a large percentage of the population will need to be vaccinated if we want to control the pandemic in the long term and prevent hospitalisation and severe illness. 

All persons in South Africa aged 18 and older were invited to complete an online survey regarding their perceptions of COVID-19 vaccines. The survey, which was available in the seven most spoken languages in the country, was advertised on social media platforms such as Facebook and Twitter, and on the Moya app.  The survey was open from 1 to 31 September 2021, and the CHSR&D received 10 554 completed questionnaires.  No data was required to complete the survey.

The Department of Basic Education partners decided on the school that would benefit, and the study provided an opportunity to support Bloemshelter, a UFS flagship programme. Alfi Moolman of the Directorate: Community Engagement said that “NGOs are really struggling to make ends meet, and we are delighted that Bloemshelter could provide the masks as one of their income-generating projects.  So many lives are touched for the good. The university is indeed a caring organisation.”


News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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