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19 October 2021 | Story André Damons | Photo Supplied
Prof Motlalepula Matsabisa, Director of Pharmacology, has received a DSI high-end infrastructure (HEI) grant to establish one of the most advanced modern Pharmacology GLP-accredited research and development laboratories in the country, and possibly in the region.

The Department of Pharmacology at the University of the Free State (UFS) will establish one of the most advanced modern Pharmacology GLP-accredited research and development laboratories in the country, and possibly in the region, after receiving a grant of R58 million. 

Prof Motlalepula Matsabisa, Director of Pharmacology, has received a DSI high-end infrastructure (HEI) grant to build the laboratory, which will be a centre of excellence for the government, the World Health Organisation (WHO), and the African Union’s (AU) Commission for Social Development. The grant will also be used to build an herbal medicines production/manufacturing facility, as well as piloting a health facility for traditional medicines. 

“I am excited to bring this huge grant to the UFS and look forward to the institution working effortlessly to become one of the leaders in this initiative. We aim to respond to our local, regional, and international research needs, our product development and commercialisation requirements, and to be competitive according to current international standards. The facility will be a unique place to learn and put theory into practice and develop the research from the bench to the hospital bedside,” says Prof Matsabisa. 

Laboratories will host students, researchers, and scientists

According to him, the research and development laboratories, as a centre of excellence, will host students, researchers, and scientists from the continent in order to practicalise and strengthen bilateral African science and technology development, as well as South-South collaborations, while maintaining its international outlook. This will lead to proper drug discovery, drug development, and product development, serving a number of clients, including communities, traditional health practitioners, the pharmaceutical industry, as well as policy makers. 

“We will develop the facilities to compete in international herbal-medicine markets.  With this injection of funding, as well as support from all our clients, namely universities – the UFS in particular – the government, and the WHO and AU, including support from traditional health practitioners, communities, and the herbal pharmaceutical industry, failure has no definition in our vocabulary and is a distant thought.”

“We will develop effective, safe, quality products under one roof – from basic and clinical research to finished, final, marketed proprietary products based on indigenous knowledge systems (IKS) and our iconic traditional medicinal botanicals,” states Prof Matsabisa.     

Under the leadership of Prof Matsabisa, the department has recently also been awarded an annual Technology and Innovation Agency Platform (TIA) grant of R17 million for the next five years. This research and teaching programme, known as African Medicines Innovations and Technologies Development (AMITD), will help to recruit and employ the best skills throughout the research, development, and herbal-medicine manufacturing value chains. 

“These investments will enable the university to play a large and key role in realising the dream of a sustainable propriety ATM industry to make an impact on health and job creation.”

AMITD will act as a national training and capacity development facility in drug research and development (R&D), and the formulation and production of quality, safe, effective, and well-researched medicines.  We hope to not only train students, but also technicians, researchers, and traditional health practitioners. The facility will afford postgraduate students a unique opportunity for research development and training at this innovative platform, with world-class specialised infrastructure and IKS academic leadership. Capacity development will be strengthened through postgraduate bursaries and postdoctoral funding by the UFS. The collaboration with the private sector will further afford opportunities for research capacity development through postgraduate job opportunities and internship training at collaborating industry partners.

Prof Matsabisa, who is also leading Africa’s fight against the COVID-19 pandemic after being appointed chairperson of the World Health Organisation’s (WHO) Regional Expert Advisory Committee on Traditional Medicines for COVID-19 last year, further states that both the laboratories – the health and the production facilities – will be state-of-the-art, with the most modern research and production equipment.

Mr Werner Nel, Director: Research Development; Dr Nico Walters, Technology Development expert consultant, and
Dr Glen Taylor, Senior Director: Research Development, were part of the ‘A-Team’ that played a role in the Department
of Pharmacology receiving a R58 million grant. (PhotoSupplied)

Platform to strengthen collaborative efforts

The university, with its commitment, proven leadership in IKS for health, extensive IKS collaborative networks across the globe, available research and pharmaceutical product development expertise, state-of-the-art manufacturing equipment and supportive research capacity development programmes, is ready and eager to host such a production facility on its Bloemfontein Campus for later growth and expansion. The production and laboratories will be ideally situated in Central South Africa, so that the facility can be accessible to all.


“We see this facility as a platform to strengthen our collaborative efforts with industry, communities, and traditional health practitioners to address their research, R&D and production needs, and strive to contribute to the local development of an African medicines-based pharmaceutical industry. The facility will also be a national asset for the training of postgraduate students and scientists in this field, with more emphasis on assisting those institutions in rural provinces,” added Prof Matsabisa. 

All of this would not have been possible without the ‘A-Team’ of Dr Glen Taylor, Senior Director: Research Development, Dr Nico Walters (expert consultant for technology development), and Mr Werner Nel (Director: Research Development), says Prof Matsabisa. 

“There are a lot of people supporting IKS directly and indirectly – from Rectorate to the Faculty of Health Sciences and the Department of Pharmacology, as well as the cleaners who ensured a clean place when the funders came for their visits, support from Pharmacology staff, students, and postdoctoral fellows. I acknowledge the unwavering support of my HOD, not forgetting colleagues and managers of other departments who also contributed to the success of this grant directly or indirectly.”

“However, in every collaboration and teamwork there are those who take the idea as theirs and ensure that they live with this idea and grow with it; I call them the A-Team,” says Prof Matsabisa. 

According to Dr Taylor, the UFS research strategy recognised the important role of IKS and African traditional medicines in the health and socio-economic fabric of our society. “Over the past five years, we have systematically built and invested in an IKS platform to become a centre of excellence, not just institutionally, but also with a national, regional, and international standing,” says Dr Taylor.

Big grant is a first 

Dr Walters says a number of government initiatives aimed at community development, job creation, scientific value addition to local products, and the utilisation of our natural resources – land and marine – have been developed. These initiatives include the IKS Act 6 of 2019, AsgiSA, Batho Pele, and the Biodiversity Initiative, aimed at the sustainable development and commercialisation of South Africa’s natural resources. 

“But never before has such a bold funding decision been made in the IKS funding sphere in the country like this one. I have been in this space of technology development and IKS development for years. This is not only the first such big grant for the UFS, but also for the country and region in terms of IKS.” 

“It was a compelling value-for-money proposal, and very difficult to shoot down with so many letters of support emanating from other universities, research councils, government departments – provincial and national – our own SAHPRA, and many other letters from the WHO, WIPO, UN bodies, including from other international universities. This is not surprising, given the recognised international scientific standing of Prof Matsabisa on all the continents. But again, more importantly, not to forget the letters of support for this facility from the pharmaceutical industry and organisations of traditional health practitioners,” says Dr Walters.   

“We would also like to acknowledge the support – through his letter of support – from our Rector and Vice-Chancellor, Prof Francis Petersen, and the institution for the idea and proposal content,” says Prof Matsabisa. 

News Archive

Volksblad: Moshoeshoe Memorial Lecture
2006-05-27

27 Mei 2006

Moshoeshoe het mense saamgebind
KONING MOSHOESHOE kon bewys dat verskeidenheid ’n bindende eienskap kan wees. Dit blyk ’n sleutelbeginsel van sy leierskap te wees – en dit is nie ’n maklike een om te begryp nie.

Jy bereik die grootste eenheid tussen onderskeidende entiteite waar jy relatief vrye ruimte aan hulle gee om hul eiesoortige kenmerke na vore te bring.

Dít blyk uit prof. Njabulo Ndebele se gedenklesing oor koning Moshoeshoe.
Lesotho; het; onder Moshoeshoe se leierskap mense van verskeie dele van die subkontinent gelok.
Dié mense het hierheen gevlug van die verwoesting wat as lifaqane bekend geword het toe Shaka sy koninkryk met militêre onderwerping verstewig het.

Ndebele het gesê daar is algemene ooreenkoms dat die oorloë wat hieruit gespruit het, die maatskaplike grondslae van talle samelewings in Suider-Afrika geskud het.

“Dit was in dié konteks dat Moshoeshoe leierskap getoon het.”
Prof. Frederick Fourie, rektor en visekanselier van die Universiteit van die Vrystaat (UV), het gesê die lesing vorm deel van ’n groter debat oor leierskapmodelle, veral die konsep van Afrika-leierskap, en die voortgesette diskoers oor nasiebou en versoening.

Die Moshoeshoe-projek is in 2004 aan die UV begin om met Suid-Afrika se eerste dekade van demokrasie saam te val.
Die projek was deel van die UV se eeufeesvieringe in 2004.
Met dié projek word geprobeer om ’n groot Afrika-leier te vereer en die UV se verbintenis tot transformasie te toon sodat ’n ware inklusiewe en nie-rassige universiteit geskep kan word.

“As die stigter van die Basoeto-nasie, word daar wyd erkenning aan koning Moshoeshoe vir sy buitengewone leierskapstyl gegee.

“Diplomasie, versoening en vreedsame naasbestaan is van die kenmerke van sy leierskap, soos getoon in sy pogings om verskillende groepe in een nasie te verenig,” sê Fourie.

KONING MOSHOESHOE, een van Afrika se eertydse groot leiers. Hy is meer as 130 jaar gelede dood. Foto: verskaf

Waarde van openbare spraak ‘nou bedreig’
AANDUIDINGS bestaan dat die waarde van openbare spraak wat hoog deur koning Moshoeshoe van Lesotho op prys gestel is, nou onder ernstige bedreiging kan wees.

Om dié rede dra hy die koning Moshoeshoe-gedenklesing op aan al dié mense in Suid-Afrika en elders wat die moed het om hul oorwoë mening uit te druk oor belangrike sake wat die samelewing in die gesig staar, het prof. Njabulo Ndebele, visekanselier van die Universiteit van Kaapstad, gesê.

Ndebele, wêreldbekende skrywer, het gesê dié lesing kom op ’n kritieke punt in Suid-Afrika se nuwe demokrasie.
Dié lesing, om die buitengewone nalatenskap van een van Afrika se groot leiers te eer, is eergisteraand op die kampus van die Universiteit van die Vrystaat (UV) gelewer en het ’n staande toejuiging deur ’n groot gehoor uitgelok.

Ndebele het gesê die mense wat hul menings uitdruk oor belangrike sake, kan rubriekskrywers, redakteurs, kommentators, alle soorte kunstenaars, akademici, koerantbriefskrywers, nie-gewelddadige optoggangers met plakkate en strokiesprentkunstenaars wees “wat ’n spieël voor ons oë sit”.

“Selfs wanneer hulle dit waag op heilige gebied, soos sommige strokiesprentkunstenaars onlangs gedoen het, herinner hulle ons net dat selfs die heilige misbruik kan word vir doeleindes wat min met heiligheid te doen het.

“Dit is hul manier om ons te help, dalk meer diepsinnig as wat ons besef, om daardie einste ruimte van heiligheid in ons lewe te bewaar.

“Hulle verdiep ons insigte deur ons begrip te verdiep.
“Dit is gepas om hul dapperheid te vier,” het Ndebele gesê.
“Hulle herinner ons dat leierskap nie al is wat ons doen wanneer ons in ’n sekere magsposisie geplaas is om ’n organisasie of ’n sekere instelling te stuur nie.”

Hy het gesê onder die mense wat gevier moet word, sluit hy nie dié in wat deur haatspraak ander aanhits om geweld te pleeg; teen; mense; wat hul andersdenkende menings lug nie.

“Dit is nie met dapperheid dat hulle aanhits nie, maar weens hul toevlug tot die narkotiese beskerming van die skare.”

Mense voel glo ál kwesbaarder
Vise-kanselier lewer Moshoeshoe-gedenklesing
’n TOENEMENDE aantal hoogs intelligente, sensitiewe en toegewyde Suid-Afrikaners oor die klas-, ras- en kulturele spektrum heen bely dat hulle – soos nog nooit tevore nie – onseker en kwesbaar voel sedert 1994.

Só het prof. Njabulo Ndebele, vise-kanselier van die Universiteit van Kaapstad, gesê in die Universiteit van die Vrystaat (UV) se eerste koning Moshoeshoe-gedenklesing.

Die onderwerp was Reflections on the leadership challenges in South Africa.
Wanneer ontembare optimiste beken hulle voel dinge is van stryk, versprei die naarheid van angs. “Dit moet iets te doen hê met ’n ophoping van gebeure wat die gevoel van dreigende inploffing oordra.”

’n Gevoel heers dat Suid-Afrika ’n baie komplekse samelewing het wat liewer eenvoudige, gesentraliseerde beheer voortbring in die hoop dat dienslewering dan beter en vinniger gedryf kan word. Die kompleksiteit van beheer word dan in ’n enkele struktuur van gesag gevestig, eerder as in die afgewentelde strukture soos wat in die Grondwet beoog word.

Dat die afgewentelde strukture nie hul grondwetlik-gedefinieerde rolle verwerklik nie, moenie toegeskryf word aan die mislukking van die beheermeganisme nie.

“Dit is te vroeg om te sê dat wat ons sedert 1994 bereik het, nie gewerk het nie,” het Ndebele gesê.
Dit lyk of ’n kombinasie van omstandighede tot die “gevoel van ontknoping” lei.
“Ek wil dit vermy om te sê: ‘Kyk na Khutsong’, asof u sal verstaan wat ek bedoel wanneer ek sê u moet na Khutsong kyk.”
Sulke kennis lei tot wanhoop, want dit roep ’n werklikheid op wat só oorweldigend is dat dit fatalisties kan wees.
Ndebele het gesê niks kon meer vreesaanjaend wees as toe ’n komplot van die Boeremag oopgevlek en sekere Boeremaglede aangekeer is nie.

Sekere Boeremaglede het van ’n maksimum-sekuriteit-tronk ontsnap. “Sover ek weet, is hulle nie weer gevang nie.
“Wat is gedoen om die gaping te oorbrug?” was een van sy vrae hieroor.
“Van só ’n belangrike saak weet die publiek nie baie nie. Die karige kommunikasie kan die gevaarlike boodskap uitdra dat óf niks gedoen word nie, óf die staat in dié saak misluk.”

Hy het gevra: “Hoekom het die kwessie van munisipale afbakening tot die situasie in Khutsong gelei? Dit lyk of die probleem voortgaan, sonder ’n oplossing in sig.”

’n Aantal soortgelyke, oënskynlik plaaslike rebellies het oor die land heen plaasgevind. “Is hier ’n patroon?”
Ndebele het na die onlangse verhoor van oud-adj.pres. Jacob Zuma, wat van verkragting aangekla was, verwys.
Dié drama blyk ver van oor te wees. Dit beloof “om ons almal sonder verligting te hou, in ’n toestand van angs”.
Die gemene draad van dié gebeure is die gevoel van ’n oneindige spiraal van probleme wat vertroue tap. Daar kan ’n sterk suggestie in al dié gebeure wees “dat ons dalk nooit sosiale samehang in Suid-Afrika gehad het nie...”

“Wat ons sekerlik oor dekades gehad het, is ’n mobiliserende visie. Kan dit wees dat die mobiliserende visie onder die gewig van die werklikheid en omvang van maatskaplike heropbouing kraak en dat die legitieme raamwerk om oor dié probleme te debatteer ineenstort?”

‘Swart mense staar hulself in die gesig’
DIE swart meerderheid staar homself nou in die gesig: dalk werklik vir die eerste keer sedert 1994.
Só het prof. Njabulo Ndebele gesê toe hy die koning Moshoeshoe-gedenklesing by die Universiteit van die Vrystaat in Bloemfontein gelewer het.

Hy het gesê dit lyk of Suid-Afrika ’n meganisme nodig het om selfvertroue te bou.
Deur dié meganisme “kan ons die situasie waarin ons is, erken, wat dit ook al is”.
“Ons het ’n meganisme nodig wat die verskillende posisies van die mededingers sal bevestig en hul eerlikheid sal bekragtig op ’n manier wat die publiek vertroue sal gee dat werklike oplossings moontlik is.”

Dit is dié soort “openheid wat nooit maklik kom nie”, wat lei tot deurbraak-oplossings.
Ndebele het gesê ’n komplekse demokrasie soos Suid-Afrika s’n kan nie oorleef met ’n enkele gesag nie.
Net veelvuldige owerhede binne ’n grondwetlike raamwerk “het ’n ware kans”.
“Kan ’n deel van die probleem wees dat ons nie in staat is om die idee van ‘opposisie’ te hanteer nie?
“Ons is verskrik dat enige van ons ‘die opposisie’ kan word.
“Dit is tyd dat ons die koms voorsien van ’n oomblik wanneer daar nie meer ’n enkele, oorweldigende, dominante politieke mag is soos wat nou die geval is nie.”

Ndebele het gesê: “Ek glo ons het dalk ’n oomblik bereik wat nie fundamenteel verskillend is nie van die ontnugterende, tóg hartversterkende nasiebourealiteite wat gelei het tot Kemptonpark in die vroeë jare negentig.”

“Die verskil tussen toe en nou is dat die swart meerderheid nie nou na wit landgenote oor die onderhandelingstafel kyk nie.

“Die swart meerderheid staar homself in die gesig: dalk werklik vir die eerste keer sedert 1994.”
Dit is weer “tyd vir visie”, het Ndebele gesê.

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