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13 September 2021 | Story Dr Nitha Ramnath

As a public higher-education institution in South Africa with a responsibility to contribute to public discourse, the University of the Free State (UFS) will be presenting the webinar as part of the Free State Literature Festival’s online initiative, VrySpraak-digitaal. 

The aim of the webinar series is to discuss issues facing South Africa by engaging experts at the university and in South Africa. Some of the topics for 2021 include, among others, reimagining universities for student success; corruption in South Africa – the endemic pandemic; South African politics and the local government elections; and Is South Africa falling apart. In 2020, the webinar series saw the successful participation of leading experts discussing COVID-19 and the crisis facing the country socially, economically, and politically. 

This year, in lieu of the Free State Arts Festival, the UFS will present the webinar virtually over a period of six months. 

Fifth webinar presented on 28 September 2021

A number of surveys have found some degree of vaccine hesitancy among the public. This webinar will clarify why we need to vaccinate against COVID-19 and why vaccines are safe. A major development in the COVID-19 pandemic has been the arrival and distribution of safe and effective vaccines. As the Delta variant of SARS-CoV-2 spreads around the world, the vaccine has proven to be safe and effective enough to prevent severe life-threatening COVID-19 complications. Although vaccines do not fully protect everyone who is vaccinated, nor guarantee zero transmission, a great deal of adherence to other measures is still required. Returning to a new normal routine of life can only happen as more people are vaccinated.


Date: Tuesday, 28 September 2021
Topic: Why vaccinate?
Time: 12:30-14:00
RSVP: Alicia Pienaar, pienaaran1@ufs.ac.za by 24 September 2021 

Facilitator:

Prof Francis Petersen
Rector and Vice-Chancellor, UFS

Panellists:

Prof Adrian Puren
Acting Executive Director
National Institute for Communicable Diseases (NICD)

Dr Nicholas Pearce

Head of Department: Surgery
Faculty of Health Sciences, UFS


Prof Glenda Gray
President and CEO
South African Medical Research Council (SAMRC)

Dr Angelique Coetzee
Chairperson
South African Medical Association (SAMA)


Bios of speakers:

Prof Puren is the newly appointed Acting Executive Director of the NICD since December 2020. He was trained and held a lectureship at the University of the Witwatersrand, before taking on various positions at the NICD. Prof Puren was appointed as Deputy Director and Head of Virology in 1999, and as Head of the Centre for HIV and STIs in 2017.  As Head of Virology, he focused on developing and implementing a range of viral diagnostic platforms in support of the NICD’s EPI surveillance programmes and diagnostic support.

His main interest is in the development of HIV surveillance programmes, with a particular focus on HIV incidence and the use of ‘big data’ to inform surveillance, monitoring, and evaluation. Prof Puren heads the regional and national endpoint diagnostics laboratory for HVTN-supported vaccine and antibody-mediated preventions trials, and he serves as the quality assurance technical manager for the NICD. In this capacity, he has provided support to the National Department of Health’s implementation and quality assurance of HIV rapid testing. Prof Puren serves on various expert bodies, the most recent of which is the South African Lancet Commission on High-Quality Health in the era of Sustainable Development Goals.

Dr Nicholas Pearce

Dr Pearce graduated from the University of the Witwatersrand in 2002, after which he completed his internship at the Universitas Academic Hospital in 2003 and has been in the Free State ever since. He completed his postgraduate training at the University of the Free State and obtained a master’s degree in General Surgery as well as a Fellowship in General Surgery from the College of Surgeons to qualify as a subspecialist in vascular surgery.

Over the years, Dr Pearce has been a consultant in general surgery, a vascular fellow and head of vascular surgery, and is currently the Head of General Surgery at the University of the Free State as well as in the Free State province. He serves on the national Association of Surgeons of South Africa (ASSA), is a member of the Vascular Society of Southern Africa and is an examiner for the College of Surgeons. He also serves on the board of the College of Surgeons as an executive member, is a member of the European Society for Vascular Surgery, and an executive member of the Surgical Research Society of South Africa.

He is responsible for undergraduate, postgraduate, and subspecialist training at the University of the Free State, as well as nationally, and is often an examiner at other institutions throughout South Africa. His publications over the years have been in the surgical field on diverse topics covering the ambit of surgery in South Africa. 

Since the beginning of the COVID-19 pandemic in 2020, he has been instrumental in setting up multiple field and surge facilities throughout the province, as well as several vaccination sites. Dr Pearce has also been involved in multiple studies on COVID-19 over the past year, is currently serving as a provincial task team member for COVID-19 and is also the Universitas COVID-19 task team chair.

Prof Glenda Gray is the President and CEO of the South African Medical Research Council (SAMRC) and former Chair of the Research Committee on COVID-19, providing scientific evidence and experience to the Minister of Health and the National Coronavirus Command Council. 

Prof Gray studied medicine and paediatrics at Wits University, where she remains Full Professor: Research in the School of Clinical Medicine. She is a National Research Foundation A1-rated scientist and is world-renowned for her research on HIV vaccines and interventions to prevent mother to child transmission of HIV. Prof Gray, together with James McIntyre, co-founded and led the globally eminent Perinatal HIV Research Unit at Chris Hani Baragwanath Hospital in Soweto, for which she and McIntyre received the Nelson Mandela Health and Human Rights Award in 2002.

She is co-principal investigator of the National Institutes of Health-funded HIV Vaccine Trials Network (HVTN) and directs the programme in Africa. 

Prof Gray’s accolades include, among others, the Hero of Medicine Award from the International Association of Physicians in AIDS Care, and the Outstanding Africa Scientist Award from the European and Developing Countries Clinical Trials Partnership.

She was named one of Africa’s 50 Most Powerful Women by Forbes, and by TIME as one of the world’s 100 Most Influential People. In 2013, Prof Gray was awarded South Africa’s highest honour, the Order of Mapungubwe. Her qualifications include MBBCh (Wits), FCPaeds (SA), DSc (honoris causa Simon Fraser University), DSc (honoris causa Stellenbosch University), and LLD (honoris causa Rhodes University).


Dr Angelique Coetzee is the National Chair of the South African Medical Association (SAMA) and is leading Pillar 5 on health service delivery of the Presidential Health Summit. She has extensive knowledge of private practice and is a member of various initiatives driving primary healthcare. Over the years, Dr Coetzee held numerous chair and vice chair positions in the SAMA on national and branch level. Dr Coetzee was a member of the National Ministerial Task Team on Military Hospitals in 2013; Chairperson Ministerial Medical Task Team on Internal and External Deployment SANDF 2014, and was elected as Vice Chair of the Medical Parole Advisory Board 2011.
Her credentials include BMedSci and MBChB (University of Pretoria), Post graduate Certificate in Advanced Health Management (CUM LAUDE)  FPD, Post graduate Higher Certificate in Criminal Justice and Forensic Investigations at the Faculty of Law from the University of Johannesburg , . She is currently completing her fraud examiners certificate with the Association of Certified Fraud Examiners (ACFE).


News Archive

Nanotechnology breakthrough at UFS
2010-08-19

 Ph.D students, Chantel Swart and Ntsoaki Leeuw


Scientists at the University of the Free State (UFS) made an important breakthrough in the use of nanotechnology in medical and biological research. The UFS team’s research has been accepted for publication by the internationally accredited Canadian Journal of Microbiology.

The UFS study dissected yeast cells exposed to over-used cooking oil by peeling microscopically thin layers off the yeast cells through the use of nanotechnology.

The yeast cells were enlarged thousands of times to study what was going on inside the cells, whilst at the same time establishing the chemical elements the cells are composed of. This was done by making microscopically small surgical incisions into the cell walls.

This groundbreaking research opens up a host of new uses for nanotechnology, as it was the first study ever in which biological cells were surgically manipulated and at the same time elemental analysis performed through nanotechnology. According to Prof. Lodewyk Kock, head of the Division Lipid Biotechnology at the UFS, the study has far reaching implications for biological and medical research.

The research was the result of collaboration between the Department of Microbial, Biochemical and Food Biotechnology, the Department of Physics (under the leadership of Prof. Hendrik Swart) and the Centre for Microscopy (under the leadership of Prof.Pieter van Wyk).

Two Ph.D. students, Chantel Swart and Ntsoaki Leeuw, overseen by professors Kock and Van Wyk, managed to successfully prepare yeast that was exposed to over-used cooking oil (used for deep frying of food) for this first ever method of nanotechnological research.

According to Prof. Kock, a single yeast cell is approximately 5 micrometres long. “A micrometre is one millionth of a metre – in laymen’s terms, even less than the diameter of a single hair – and completely invisible to the human eye.”

Through the use of nanotechnology, the chemical composition of the surface of the yeast cells could be established by making a surgical incision into the surface. The cells could be peeled off in layers of approximately three (3) nanometres at a time to establish the effect of the oil on the yeast cell’s composition. A nanometre is one thousandth of a micrometre.

Each cell was enlarged by between 40 000 and 50 000 times. This was done by using the Department of Physics’ PHI700 Scanning Auger Nanoprobe linked to a Scanning Electron Microscope and Argon-etching. Under the guidance of Prof. Swart, Mss. Swart en Leeuw could dissect the surfaces of yeast cells exposed to over-used cooking oil. 

The study noted wart like outgrowths - some only a few nanometres in diameter – on the cell surfaces. Research concluded that these outgrowths were caused by the oil. The exposure to the oil also drastically hampered the growth of the yeast cells. (See figure 1)  

Researchers worldwide have warned about the over-usage of cooking oil for deep frying of food, as it can be linked to the cause of diseases like cancer. The over-usage of cooking oil in the preparation of food is therefore strictly regulated by laws worldwide.

The UFS-research doesn’t only show that over-used cooking oil is harmful to micro-organisms like yeast, but also suggests how nanotechnology can be used in biological and medical research on, amongst others, cancer cells.

 

Figure 1. Yeast cells exposed to over-used cooking oil. Wart like protuberances/ outgrowths (WP) is clearly visible on the surfaces of the elongated yeast cells. With the use of nanotechnology, it is possible to peel off the warts – some with a diameter of only a few nanometres – in layers only a few nanometres thick. At the same time, the 3D-structure of the warts as well as its chemical composition can be established.  

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt@ufs.ac.za  
18 August 2010
 

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