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30 September 2021 | Story Marius Coetzee and Rulanzen Martin | Photo Supplied
From the left: Werner Stolze of Stolze Pianos (sponsor), Karlin Kock (Trio Con Brio), Dr Mageshen Naidoo (adjudicator – UP), Kagiso Ramosa (Trio Con Brio), Renette Bouwer (adjudicator – UJ), Maria Yasbeck (Trio Con Brio), and Prof Wessel van Wyk from UP.

The Trio Con Brio ensemble in the Odeion School of Music (OSM) was crowned winners of the open category during the final round of the national SASMT Ensemble competition, which took place on 22 September 2021.  The Trio Con Brio comprises OSM students Kagiso Ramosa (clarinet), Maria Yasbeck (violin), and Karlin Kock (piano).

OSM lecturers, Drs Danre Strydom, Sharon de Kock, and Anneke Lamont served as instructors and mentors during the preparation phase. “The trio prepared their concert programme with an interesting methodology, by having weekly instruction from all lecturers individually on a rotation basis,” says Marius Coetzee, Artistic Director of the Odeion School of Music Camerata (OSMC). Elsabé Raath serves as the principal instructor. 

The OSMC took second place in the concert programme, while the instructor of the OSM Brass Quintet, George Foster, and the convenor, Quinn Kakora, were also selected to participate in the first round of the competition. Their recital was highly ranked and came third in the first round.

 SASMT competition develops young musicians 

The first SASMT Pretoria Ensemble Competition took place in September 2017. It would be the first competition of this nature to be held in the northern region of South Africa. The goal was to create an opportunity for young musicians to compete in groups, rather than focusing on solo performances. The feedback from the initial competition was overwhelmingly positive, culminating in the decision to make it an annual event.

The competition aims to develop young musicians through collaborative participation and by encouraging the enjoyment of performing with others. Another objective is to foster understanding, love, and appreciation for ensemble music and the performance thereof among young musicians. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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