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Andre Roodt and Alice Brink
Prof Andreas Roodt and Prof Alice Brink are two of the inventors of the ‘Multinuclear complexes and their preparation patent.

According to the World Health Organisation (WHO), cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six. The most common cancers are breast, lung, colon, rectum, and prostate cancers. There is a constant need to provide methods to diagnose and treat cancer-related tumours.  Current research strategies focus on eliminating cancer cells with the minimum damage to surrounding healthy cells.

A limitation of current technologies is that they are mostly based on the separate identification of cancer (diagnostic), followed by treatment (therapy) using chemotherapy and/or radiotherapy. To fit both needs at the same time and with similar or identical compounds, the principle of theranostic medicine was identified. This concept employs both diagnosing (by imaging) cancer and delivering therapy (treatment) simultaneously, which has been receiving increased attention internationally.

Collaborating with the University of Zurich
A University of the Free State (UFS) team, together with a team from the University of Zürich, conducted exciting research in this area and filed a patent titled ‘Multinuclear complexes and their preparation’. The patent was granted in South Africa and by the European Patent Office. It is being validated in selected European countries. The patent is pending in the USA, Japan, Hong Kong, and India. The inventors from the UFS are Prof Andreas Roodt, Prof Alice Brink, Dr Pennie Mokolokolo, and Dr Vincent Dumisani Kama. The approach that their technology takes is to enable the synthesis of a multinuclear compound/s, which may contain different pre-selected radioisotopes, to allow both imaging and therapy to the cancer site(s) with one and the same metal-organic complex.

So far, high-yield production of compounds has been successfully innovated, which contain both an imaging (in particular the widely utilised imaging isotope Technetium-99m) and therapeutic (typically the therapeutic isotope Rhenium-186) radioactive isotope(s), optionally carrying an additional cytotoxic agent. (Chemotherapy uses anti-cancer [cytotoxic] drugs to destroy cancer cells.)

Nuclear medicine technologies
In the next phase of the research, a lead compound portfolio of four to five model pharmaceuticals containing these metal nuclides with appropriate directing groups to target cancer sites will be designed and constructed. A number of these entities are known and can be introduced through different techniques. These will then undergo full characterisation and efficacy evaluation in biological models (in vitro), followed by extensive animal and human trials.

The technology will be delivered as a product or service in the way that current nuclear medicine technologies are delivered.

The fact that this product(s) contains both imaging and therapeutic radionuclides or cytotoxic modalities, enables detailed tracking of the pharmaceutical and monitoring of the tumours' response to the therapy. Not directly related to the patent, but an asset to it, is the fact that the incorporation of rhenium with a high atomic number (Z = 75) opens the additional opportunity to utilise the multinuclear compounds also as radiosensitisers. Synergistic effects, enhancing the therapeutic efficacy, can thus be expected in combination with radiotherapy.

The UFS would like to partner with a pharmaceutical company working in the field of nuclear medicine to commercialise this technology. Interested parties can contact Ravini Moodley at MoodleyR5@ufs.ac.za

News Archive

UFS celebrates Kovsie Week
2009-08-21

The University of the Free State (UFS) will be celebrating Kovsie Week from 31 August to 4 September 2009. The week affords friends, colleagues and former colleagues of the UFS the opportunity to enjoy one another’s company and to experience what the university offers.

The programme is as follows:

On Monday, 31 August 2009, a star-gazing programme and lecture entitled “400 Years of Astronomy after Galileo” are presented by Prof. Matie Hoffman at the Boyden Observatory at 17:30 for 18:00. Attendance is free and bus transport will be available from the UFS Main Campus for the first 70 guests that respond. Reserved parking has been arranged with a security guard to look after the cars that are left on the campus.

On Tuesday, 1 September 2009, guests can attend the production by Pieter Venter entitled “Impi” for free in the Wynand Mouton Theatre at 14:30 for 15:00.

On Wednesday, 2 September 2009, an enjoyable morning in the company of Mr Derek de Bruyn from the National Museum is presented at the Centenary Complex of the UFS at 09:30 for 10:00. He will talk about the social life of Bloemfontein during the early 1900s and guests will be entertained by the Boere Orkes of Grey College Primary School under the direction of Santjie Louw. Attendance of this event is free.

On Thursday, 3 September 2009, at 19:00 for 19:30, a candle-light, sherry and soup evening with romantic piano music is presented at the UFS Centenary Complex by Prof. Nicol Viljoen from the UFS’s Department of Music. The programme includes, amongst others, 10 Lieder ohne worte (Felix Mendelssohn), as well as Ballade No. 1 (Fryderyk Chopin). Attendance of this event is also free.

The week will end with the Kovsie-Alumni Award Gala Dinner that will take place in the UFS Centenary Complex on Friday, 4 September 2009, at 18:30 for 19:00.
The cost per person for the dinner is R120. The Kovsie of the Year Award for alumni, the Cum Laude Award, and the Alumni Award for Exceptional Service at the UFS will be awarded at this occasion.

Transport can be arranged to all the functions and parking will be available as close as possible to the venue where the functions take place. Persons interested to attend any of the functions can contact Annanda Calitz at 051 401 3382 or ficka.stg@ufs.ac.za, or Ms Kathy Verwey at 051 401 9343 or verweyke.stg@ufs.ac.za.

Media Release
Issued by: Lacea Loader
Deputy Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
21 August 2009

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