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25 April 2022 | Story Elsabé Brits
Andre Roodt and Alice Brink
Prof Andreas Roodt and Prof Alice Brink are two of the inventors of the ‘Multinuclear complexes and their preparation patent.

According to the World Health Organisation (WHO), cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six. The most common cancers are breast, lung, colon, rectum, and prostate cancers. There is a constant need to provide methods to diagnose and treat cancer-related tumours.  Current research strategies focus on eliminating cancer cells with the minimum damage to surrounding healthy cells.

A limitation of current technologies is that they are mostly based on the separate identification of cancer (diagnostic), followed by treatment (therapy) using chemotherapy and/or radiotherapy. To fit both needs at the same time and with similar or identical compounds, the principle of theranostic medicine was identified. This concept employs both diagnosing (by imaging) cancer and delivering therapy (treatment) simultaneously, which has been receiving increased attention internationally.

Collaborating with the University of Zurich
A University of the Free State (UFS) team, together with a team from the University of Zürich, conducted exciting research in this area and filed a patent titled ‘Multinuclear complexes and their preparation’. The patent was granted in South Africa and by the European Patent Office. It is being validated in selected European countries. The patent is pending in the USA, Japan, Hong Kong, and India. The inventors from the UFS are Prof Andreas Roodt, Prof Alice Brink, Dr Pennie Mokolokolo, and Dr Vincent Dumisani Kama. The approach that their technology takes is to enable the synthesis of a multinuclear compound/s, which may contain different pre-selected radioisotopes, to allow both imaging and therapy to the cancer site(s) with one and the same metal-organic complex.

So far, high-yield production of compounds has been successfully innovated, which contain both an imaging (in particular the widely utilised imaging isotope Technetium-99m) and therapeutic (typically the therapeutic isotope Rhenium-186) radioactive isotope(s), optionally carrying an additional cytotoxic agent. (Chemotherapy uses anti-cancer [cytotoxic] drugs to destroy cancer cells.)

Nuclear medicine technologies
In the next phase of the research, a lead compound portfolio of four to five model pharmaceuticals containing these metal nuclides with appropriate directing groups to target cancer sites will be designed and constructed. A number of these entities are known and can be introduced through different techniques. These will then undergo full characterisation and efficacy evaluation in biological models (in vitro), followed by extensive animal and human trials.

The technology will be delivered as a product or service in the way that current nuclear medicine technologies are delivered.

The fact that this product(s) contains both imaging and therapeutic radionuclides or cytotoxic modalities, enables detailed tracking of the pharmaceutical and monitoring of the tumours' response to the therapy. Not directly related to the patent, but an asset to it, is the fact that the incorporation of rhenium with a high atomic number (Z = 75) opens the additional opportunity to utilise the multinuclear compounds also as radiosensitisers. Synergistic effects, enhancing the therapeutic efficacy, can thus be expected in combination with radiotherapy.

The UFS would like to partner with a pharmaceutical company working in the field of nuclear medicine to commercialise this technology. Interested parties can contact Ravini Moodley at MoodleyR5@ufs.ac.za

News Archive

UFS hockey teams crowned as Free State hockey champions
2009-09-21

The University of the Free State’s (UFS) men’s and women’s hockey teams were recently crowned as the Free State hockey champions during the championship that took place on the university's astro fields in Bloemfontein.

Kovsie women defeated Raiders (the defending champions) 6-0 and the Kovsie men’s hockey team successfully defended their title against Tweespruit. During a penalty shootout UFS Reds beat the team of the Central University of Technology (CUT 1) 8-7, thereby ending in the third position.

Very early on the Kovsie women’s hockey team showed that they wanted to break the five-year drought without a trophy and within the first ten minutes they took the lead with 2-0 against Raiders. Liza Dreyer scored her first two goals out of four and from that moment on the Raiders were with their backs against the wall. With the score of 4-0 at halftime it was clear that Kovsies would have a second trophy in their cupboard after their recent success during the USSA championships. After halftime, Odie Swart scored another goal from a penalty corner and Liza scored her fourth goal, to bring the end score to 6-0. Malisa Kala was the other Kovsie who scored a goal.

Odie Swart, captain of the Kovsies played her last match for the Kovsies with Cat van Zuydam. She excelled in the attack as well as in the defence.

The Kovsies men’s hockey team has now done it three out of three times! Within the first twenty minutes the Kovsies men’s hockey team defeated Tweespruit with brilliant hockey by scoring three goals. Luke Sanan (2) and Kurt Henzberg (1) scored the goals. All three the goals were well-executed field goals. The current Kovsie team is surely the best-rounded hockey team that the Free State has had over the last ten years. In the past three years the students played in more than 45 club matches and they did not lose one match!

With the joy also comes sadness. For Braam van Wyk it was his last match as coach of a Kovsie team. For the past 17 years Braam has been involved with Kovsie hockey, in which he led the girls to twelve victories in the Free State league. The last three years he managed the men’s team, who won the league for the past three consecutive years, indeed an achievement. With Braam, three other senior players of the past three years made their last appearance for Kovsies. They are Morne Odendaal, Renaldo Ogle and Braam van Wyk (jr.).

Literally during the last moments of their game against CUT 1, the UFS Reds, who were 1-4 behind, scored a goal, which brought the final score to 4-4. The Kovsie students won the penalty shootout with 4-3, thereby winning 8-7 and thus ending third in this year’s men’s Free State league. 
 

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