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25 April 2022 | Story Elsabé Brits
Andre Roodt and Alice Brink
Prof Andreas Roodt and Prof Alice Brink are two of the inventors of the ‘Multinuclear complexes and their preparation patent.

According to the World Health Organisation (WHO), cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six. The most common cancers are breast, lung, colon, rectum, and prostate cancers. There is a constant need to provide methods to diagnose and treat cancer-related tumours.  Current research strategies focus on eliminating cancer cells with the minimum damage to surrounding healthy cells.

A limitation of current technologies is that they are mostly based on the separate identification of cancer (diagnostic), followed by treatment (therapy) using chemotherapy and/or radiotherapy. To fit both needs at the same time and with similar or identical compounds, the principle of theranostic medicine was identified. This concept employs both diagnosing (by imaging) cancer and delivering therapy (treatment) simultaneously, which has been receiving increased attention internationally.

Collaborating with the University of Zurich
A University of the Free State (UFS) team, together with a team from the University of Zürich, conducted exciting research in this area and filed a patent titled ‘Multinuclear complexes and their preparation’. The patent was granted in South Africa and by the European Patent Office. It is being validated in selected European countries. The patent is pending in the USA, Japan, Hong Kong, and India. The inventors from the UFS are Prof Andreas Roodt, Prof Alice Brink, Dr Pennie Mokolokolo, and Dr Vincent Dumisani Kama. The approach that their technology takes is to enable the synthesis of a multinuclear compound/s, which may contain different pre-selected radioisotopes, to allow both imaging and therapy to the cancer site(s) with one and the same metal-organic complex.

So far, high-yield production of compounds has been successfully innovated, which contain both an imaging (in particular the widely utilised imaging isotope Technetium-99m) and therapeutic (typically the therapeutic isotope Rhenium-186) radioactive isotope(s), optionally carrying an additional cytotoxic agent. (Chemotherapy uses anti-cancer [cytotoxic] drugs to destroy cancer cells.)

Nuclear medicine technologies
In the next phase of the research, a lead compound portfolio of four to five model pharmaceuticals containing these metal nuclides with appropriate directing groups to target cancer sites will be designed and constructed. A number of these entities are known and can be introduced through different techniques. These will then undergo full characterisation and efficacy evaluation in biological models (in vitro), followed by extensive animal and human trials.

The technology will be delivered as a product or service in the way that current nuclear medicine technologies are delivered.

The fact that this product(s) contains both imaging and therapeutic radionuclides or cytotoxic modalities, enables detailed tracking of the pharmaceutical and monitoring of the tumours' response to the therapy. Not directly related to the patent, but an asset to it, is the fact that the incorporation of rhenium with a high atomic number (Z = 75) opens the additional opportunity to utilise the multinuclear compounds also as radiosensitisers. Synergistic effects, enhancing the therapeutic efficacy, can thus be expected in combination with radiotherapy.

The UFS would like to partner with a pharmaceutical company working in the field of nuclear medicine to commercialise this technology. Interested parties can contact Ravini Moodley at MoodleyR5@ufs.ac.za

News Archive

Thakaneng bridge: Valentines Promotions
2009-02-13

Thakaneng bridge: Valentines Promotions

Thakaneng bridge: Valentines Promotions - 13 February. Special discount! Prizes to be won!

  1. TRÄUMEREI

Enige twee ontbyte kry `n glasie sap en koffie gratis.
Enige middagete kry `n trammazini of glas huiswyn gratis.

Any two breakfasts get a free juice and coffee.
A free glass of wine or a trammazini with any lunch.

  1. VARSITY INFORMATION & TECHNOLOGY

Spend R1000.00 or more and stand a chance to win an Ipod Shuffle.
More specials in store.

Spandeer R1000.00 of meer en staan `n kans om `n Ipod Shuffle te wen.
Daar sal ook ander spesiale aanbiedinge in die winkel wees.

  1. VETKOEK FACTORY

Heart shaped vetkoek with delicious fillings and get a free heart shaped chocolate with every vetkoek.

Kom geniet `n hartvormige vetkoek met `n smaaklike vulsel en kry `n gratis hartvormige sjokolade.

  1. VARSITY HAIR STUDIO

Make Friday the 13th your lucky day at VARSITY HAIR STUDIO.
Amazing discounts will be given away!

Maak Vrydag die 13de jou gelukkige dag by VARSITY HAIR STUDIO.
Groot afslag op byna alles.

  1. KOVSIE PRIVAAT AKKOMMODASIE

Alle bestaande klante kom neem deel aan `n gelukstrekking en staan `n kans om `n etebewys ter waarde van R400.00 te wen.

All existing clients can enter into a lucky draw and stand a chance to win a free meal worth R400.00.

  1. XEROX

Kom neem deel aan `n “lucky draw” en wen een van verskeie geskenke.
Enter the lucky draw and win one of many prizes.

  1. MELLIN

LEVI, POLO en LUXION-KUKA promosies. Gratis geskenke wannneer `n raam gekoop word.
LEVI, POLO and LUXION-KUKA promotions. A free gift with any frame bought.

8. FRIENDLY SEVEN ELEVEN
Lots of in-store give-aways.
Vele weggee geskenke in die winkel. Besoek ons gerus.

9. RUSH HOUR
Kom prik `n ballon en wen een van vele pryse, waaronder T-hemde, `n koek, teddiebeer of dalk ‘n mini- make over.
Ons maak ook `n plan vir lekker musiek op die brug!

Win a cake, T-shirt ,a teddy bear or a mini make over in our burst a balloon competition.

10.MAMA`S KITCHEN
Kom neem deel aan `n gelukstrekking en wen `n piekniekmandjie vir twee.
`n Gratis geskenkie vir die eerste 100 klante.

Enter the lucky draw and stand a chance to win a picnic hamper for two.
The first 100 clients will receive a gift.

11. ROASTERS
Kom koop een chip twister en kry een gratis.
Buy ` chip twister and get one for free.

12 DIE DELI

Koop een groot ontbyt en kry `n damesontbyt gratis.
Kry skyfies gratis saam met enige burger.

Buy a breakfast and get a ladies breakfast free.
Free chips with any burger.

  1. NASHUA MOBILE

Buy airtime for R10.00 or more and stand a chance to win airtime worth R55.00
Koop lugtyd van R10.00 of meer en staan `n kans om lugtyd ter waarde van R55.00 te wen.

  1. VAN SCHAIK BOEKHANDEL

Alle aankope op 13 Februarie kwalifiseer vir `n gelukstrekking op die 14de Februarie en staan `n kans om `n geskenk te wen waaronder wetenskaplike sakrekenaars, memory sticks en penstelle.

All clients who buy something on 13 February 2009 may enter a lucky draw and may win gifts like pen sets, scientific calculator or a memory stick on 14 February 2009.

  1. ROCKSTARS

Kom koop `n T-hemp en staan `n kans om `n geskenk te wen.

Buy a T-shirt and stand a chance to win a prize

 

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