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25 April 2022 | Story Elsabé Brits
Andre Roodt and Alice Brink
Prof Andreas Roodt and Prof Alice Brink are two of the inventors of the ‘Multinuclear complexes and their preparation patent.

According to the World Health Organisation (WHO), cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six. The most common cancers are breast, lung, colon, rectum, and prostate cancers. There is a constant need to provide methods to diagnose and treat cancer-related tumours.  Current research strategies focus on eliminating cancer cells with the minimum damage to surrounding healthy cells.

A limitation of current technologies is that they are mostly based on the separate identification of cancer (diagnostic), followed by treatment (therapy) using chemotherapy and/or radiotherapy. To fit both needs at the same time and with similar or identical compounds, the principle of theranostic medicine was identified. This concept employs both diagnosing (by imaging) cancer and delivering therapy (treatment) simultaneously, which has been receiving increased attention internationally.

Collaborating with the University of Zurich
A University of the Free State (UFS) team, together with a team from the University of Zürich, conducted exciting research in this area and filed a patent titled ‘Multinuclear complexes and their preparation’. The patent was granted in South Africa and by the European Patent Office. It is being validated in selected European countries. The patent is pending in the USA, Japan, Hong Kong, and India. The inventors from the UFS are Prof Andreas Roodt, Prof Alice Brink, Dr Pennie Mokolokolo, and Dr Vincent Dumisani Kama. The approach that their technology takes is to enable the synthesis of a multinuclear compound/s, which may contain different pre-selected radioisotopes, to allow both imaging and therapy to the cancer site(s) with one and the same metal-organic complex.

So far, high-yield production of compounds has been successfully innovated, which contain both an imaging (in particular the widely utilised imaging isotope Technetium-99m) and therapeutic (typically the therapeutic isotope Rhenium-186) radioactive isotope(s), optionally carrying an additional cytotoxic agent. (Chemotherapy uses anti-cancer [cytotoxic] drugs to destroy cancer cells.)

Nuclear medicine technologies
In the next phase of the research, a lead compound portfolio of four to five model pharmaceuticals containing these metal nuclides with appropriate directing groups to target cancer sites will be designed and constructed. A number of these entities are known and can be introduced through different techniques. These will then undergo full characterisation and efficacy evaluation in biological models (in vitro), followed by extensive animal and human trials.

The technology will be delivered as a product or service in the way that current nuclear medicine technologies are delivered.

The fact that this product(s) contains both imaging and therapeutic radionuclides or cytotoxic modalities, enables detailed tracking of the pharmaceutical and monitoring of the tumours' response to the therapy. Not directly related to the patent, but an asset to it, is the fact that the incorporation of rhenium with a high atomic number (Z = 75) opens the additional opportunity to utilise the multinuclear compounds also as radiosensitisers. Synergistic effects, enhancing the therapeutic efficacy, can thus be expected in combination with radiotherapy.

The UFS would like to partner with a pharmaceutical company working in the field of nuclear medicine to commercialise this technology. Interested parties can contact Ravini Moodley at MoodleyR5@ufs.ac.za

News Archive

UFS intensifies its advocacy on humanity and solidarity to Japan
2011-03-08

Staff and students from our university, marching for humanity
Photo: Stephen Collett

Staff and students from the University of the Free State (UFS) representing various associations and student bodies, together with Kovsie supporters, braved the cold and wet weather yesterday (17 March) as they embarked on a march for humanity. This occurred just two days after an urgent meeting had been called by the Dean of Student Affairs, Mr Rudi Buys to create a platform for students to deliberate on mechanisms to be used in supporting Japan, which is facing immense challenges, thereby responding to their unfortunate current situation. It is also a day after the direct conversation between the UFS and the South African ambassador to Japan, Mr Gert Grobler, a Kovsie alumnus.

The visibly spirited group started their march from the Main Building on the UFS Main Campus in Bloemfontein. Within minutes the Callie Human Centre – assembly point for the participants – was occupied by students and staff members who arrived in their numbers, carrying banners with messages of support for Japan.

Modieyi Motholo, ISC Chairperson, read a memorandum in the presence of more than 300 students. “We, the community of the University of the Free State, as sons and daughters of South Africa and the world, by our very action in this march today, celebrate our shared humanity, declare our solidarity with the people of Japan, and join the movement to build a culture of Human Rights. We declare our commitment to the cause of human dignity and equality, and the promotion of human rights, non-racialism and non-sexism,” read the memorandum. 

“Japan is far; we shall never be able to take the entire Kovsie community there to assist the Japanese in rebuilding their homes. However, we can show our solidarity and raise an awareness for their unfortunate circumstances by our numbers,” Modieyi said.

Mr Buys admitted to being overwhelmed by the united Kovsie community he witnessed standing up for a cause they believed in. On receiving the memorandum on behalf of the UFS management, he stated: “There is a different and new set of values in our student community. We have the best students in the world, driven by a pioneering spirit aimed at building a new society. We have come so far in a short period of time. You deserve recognition as a student population.”

The march was also organised to declare the UFS’s support and solidarity for the people of Japan. The solidarity campaign has further been intensified with the establishment of committees comprising fundraising, research, marketing and awareness, spirituality and volunteers. Nida Jooste, the ISC Vice-Chairperson, said that the research committee was busy conducting a comprehensive study on how the UFS can be of assistance to the Japan. “With the report we will be able to design and implement programmes that will be aligned with the needs of the people of Japan. “In the meantime, we will carry out small projects that will keep the flame of solidarity burning on our campus,” she concluded.

Noticeable amongst the attendees were Mr John Samuels, the current Director of the International Institute for Studies in Race, Reconciliation and Social Justice.

 

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