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25 April 2022 | Story Elsabé Brits
Andre Roodt and Alice Brink
Prof Andreas Roodt and Prof Alice Brink are two of the inventors of the ‘Multinuclear complexes and their preparation patent.

According to the World Health Organisation (WHO), cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six. The most common cancers are breast, lung, colon, rectum, and prostate cancers. There is a constant need to provide methods to diagnose and treat cancer-related tumours.  Current research strategies focus on eliminating cancer cells with the minimum damage to surrounding healthy cells.

A limitation of current technologies is that they are mostly based on the separate identification of cancer (diagnostic), followed by treatment (therapy) using chemotherapy and/or radiotherapy. To fit both needs at the same time and with similar or identical compounds, the principle of theranostic medicine was identified. This concept employs both diagnosing (by imaging) cancer and delivering therapy (treatment) simultaneously, which has been receiving increased attention internationally.

Collaborating with the University of Zurich
A University of the Free State (UFS) team, together with a team from the University of Zürich, conducted exciting research in this area and filed a patent titled ‘Multinuclear complexes and their preparation’. The patent was granted in South Africa and by the European Patent Office. It is being validated in selected European countries. The patent is pending in the USA, Japan, Hong Kong, and India. The inventors from the UFS are Prof Andreas Roodt, Prof Alice Brink, Dr Pennie Mokolokolo, and Dr Vincent Dumisani Kama. The approach that their technology takes is to enable the synthesis of a multinuclear compound/s, which may contain different pre-selected radioisotopes, to allow both imaging and therapy to the cancer site(s) with one and the same metal-organic complex.

So far, high-yield production of compounds has been successfully innovated, which contain both an imaging (in particular the widely utilised imaging isotope Technetium-99m) and therapeutic (typically the therapeutic isotope Rhenium-186) radioactive isotope(s), optionally carrying an additional cytotoxic agent. (Chemotherapy uses anti-cancer [cytotoxic] drugs to destroy cancer cells.)

Nuclear medicine technologies
In the next phase of the research, a lead compound portfolio of four to five model pharmaceuticals containing these metal nuclides with appropriate directing groups to target cancer sites will be designed and constructed. A number of these entities are known and can be introduced through different techniques. These will then undergo full characterisation and efficacy evaluation in biological models (in vitro), followed by extensive animal and human trials.

The technology will be delivered as a product or service in the way that current nuclear medicine technologies are delivered.

The fact that this product(s) contains both imaging and therapeutic radionuclides or cytotoxic modalities, enables detailed tracking of the pharmaceutical and monitoring of the tumours' response to the therapy. Not directly related to the patent, but an asset to it, is the fact that the incorporation of rhenium with a high atomic number (Z = 75) opens the additional opportunity to utilise the multinuclear compounds also as radiosensitisers. Synergistic effects, enhancing the therapeutic efficacy, can thus be expected in combination with radiotherapy.

The UFS would like to partner with a pharmaceutical company working in the field of nuclear medicine to commercialise this technology. Interested parties can contact Ravini Moodley at MoodleyR5@ufs.ac.za

News Archive

Almost 2000 degrees and diplomas conferred at Winter Graduation
2015-06-26

Live streaming will be available on: http://livestream.ufs.ac.za/

The 2015 Winter Graduations are almost underway. The highlight on the university calendar for every graduate will take place on the Bloemfontein Campus on 1-2 July 2015. On 1 July 2015, diplomas will be awarded by the Centre of Financial Planning Law (331 in total) and the School of Open Learning (376 in total). On 2 July 2015, a total of 1 220 master’s and doctoral degrees will be awarded to graduates from all seven faculties.

A highlight at this year’s Winter Graduation is the awarding of three honorary degrees by the university. Ambassador Lakhdar Brahimi, Dr Mercy Oduyoye and Mr John Samuel will receive honorary degrees.

On 17 August 2012, Ambassador Brahimi was appointed by the United Nations as the new peace envoy to Syria, replacing Kofi Annan. He is also a member of the Commission on Legal Empowerment of the Poor, the first global initiative to focus specifically on the link between exclusion, poverty and the law. Prof Heidi Hudson, Head of the Centre for Africa Studies at the UFS, will receive the honorary degree on his behalf.

Dr Oduyoye is widely regarded as one of the most influential women theologians Africa has produced in recent history. Currently, she directs the Institute of African Women in Religion and Culture at the Trinity Theology Seminary in Legon, Ghana.

Mr John Samuel, who will receive an honorary award, is also scheduled to be a guest speaker at the two ceremonies on 1 July 2015.

Wednesday 1 July 2015:

John Samuel will be the speaker at both ceremonies. He is one of South Africa’s leading education experts with international and national experience, covering a period of more than forty years. He was involved in the founding of the South African Campaign: Public Participation in Education Network (PPEN), established the Centre for Education Policy Development, the Joint Working Group (for The National Party Government and the ANC), the National Education Conference, and the National Education and Training Forum. He also made leadership contributions to the First Education and Training White Paper, the Transformation Strategy for the National Education Department, and the first Green Paper on Higher Education.

John is also Senior Programme Director of the WK Kellogg Foundation in the USA. He has also been the Chief Executive of the Nelson Mandela Foundation, and the CEO of the Oprah Winfrey Leadership Academy for Girls.

Thursday 2 July 2015:

Nataniël will be the speaker at both ceremonies. Nataniël is a singer, songwriter, and South African entertainer, who has crossed from the alternative circuit to the stage. For the past 10 years, he has become well-known for his outspoken Kaalkop column in SARIE magazine. His solo career was launched in 1987 and, since then, he has released 16 albums, staged more than 70 original theatre productions, and published 15 books. Over the past two decades, Nataniël has gained the title of South Africa’s leading exponent of the solo stage act. He manages Kaalkop Studio, his lifestyle retail company, and records on his own independent label, Nataniël House Of Music. He is an ambassador for Child Welfare SA, and also heads his own charitable foundation, The Nataniël Progress Project.

 

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