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25 April 2022 | Story Elsabé Brits
Andre Roodt and Alice Brink
Prof Andreas Roodt and Prof Alice Brink are two of the inventors of the ‘Multinuclear complexes and their preparation patent.

According to the World Health Organisation (WHO), cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six. The most common cancers are breast, lung, colon, rectum, and prostate cancers. There is a constant need to provide methods to diagnose and treat cancer-related tumours.  Current research strategies focus on eliminating cancer cells with the minimum damage to surrounding healthy cells.

A limitation of current technologies is that they are mostly based on the separate identification of cancer (diagnostic), followed by treatment (therapy) using chemotherapy and/or radiotherapy. To fit both needs at the same time and with similar or identical compounds, the principle of theranostic medicine was identified. This concept employs both diagnosing (by imaging) cancer and delivering therapy (treatment) simultaneously, which has been receiving increased attention internationally.

Collaborating with the University of Zurich
A University of the Free State (UFS) team, together with a team from the University of Zürich, conducted exciting research in this area and filed a patent titled ‘Multinuclear complexes and their preparation’. The patent was granted in South Africa and by the European Patent Office. It is being validated in selected European countries. The patent is pending in the USA, Japan, Hong Kong, and India. The inventors from the UFS are Prof Andreas Roodt, Prof Alice Brink, Dr Pennie Mokolokolo, and Dr Vincent Dumisani Kama. The approach that their technology takes is to enable the synthesis of a multinuclear compound/s, which may contain different pre-selected radioisotopes, to allow both imaging and therapy to the cancer site(s) with one and the same metal-organic complex.

So far, high-yield production of compounds has been successfully innovated, which contain both an imaging (in particular the widely utilised imaging isotope Technetium-99m) and therapeutic (typically the therapeutic isotope Rhenium-186) radioactive isotope(s), optionally carrying an additional cytotoxic agent. (Chemotherapy uses anti-cancer [cytotoxic] drugs to destroy cancer cells.)

Nuclear medicine technologies
In the next phase of the research, a lead compound portfolio of four to five model pharmaceuticals containing these metal nuclides with appropriate directing groups to target cancer sites will be designed and constructed. A number of these entities are known and can be introduced through different techniques. These will then undergo full characterisation and efficacy evaluation in biological models (in vitro), followed by extensive animal and human trials.

The technology will be delivered as a product or service in the way that current nuclear medicine technologies are delivered.

The fact that this product(s) contains both imaging and therapeutic radionuclides or cytotoxic modalities, enables detailed tracking of the pharmaceutical and monitoring of the tumours' response to the therapy. Not directly related to the patent, but an asset to it, is the fact that the incorporation of rhenium with a high atomic number (Z = 75) opens the additional opportunity to utilise the multinuclear compounds also as radiosensitisers. Synergistic effects, enhancing the therapeutic efficacy, can thus be expected in combination with radiotherapy.

The UFS would like to partner with a pharmaceutical company working in the field of nuclear medicine to commercialise this technology. Interested parties can contact Ravini Moodley at MoodleyR5@ufs.ac.za

News Archive

Campus-wide poll to determine preferences among current staff and students for language models
2015-10-20

Language poll postponed until Thursday 22 October 2015

Due to the closing down of all UFS campuses on Wednesday 21 October 2015, the language poll has been postponed until Thursday 22 October 2015.

 

Invitation to take part in a campus-wide poll to determine preferences among current staff and students for language models.

As mandated by the Council on 5 June 2015, the senior leadership of the University of the Free State (UFS) has committed itself to a formal review process of the current language policy through a comprehensive process of consultation with all university stakeholders.

Since 19 August 2015, the following public sessions have taken place across all three campuses:

  • Public dialogue for staff and students, Qwaqwa Campus, 19 August 2015
  • Staff submissions, Bloemfontein Campus, 20 August 2015
  • External stakeholder submissions, Bloemfontein Campus, 24 August 2015
  • Public dialogue for staff and students, South Campus, 26 August 2015
  • Alumni submissions, Bloemfontein Campus, 27 August 2015
  • Expert panel discussion for staff and students with Q&A, Bloemfontein Campus, 31 August 2015
  • Staff, students, and external stakeholder submissions, Qwaqwa Campus, 9 September 2015
  • Panel discussion and public dialogue for students, Bloemfontein Campus, 10 September 2015
  • Expert panel discussion for staff and students with Q&A, Bloemfontein Campus, 11 September 2015
  • Student submissions, Bloemfontein Campus, 15 September 2015
  • Staff and student submissions, South Campus, 16 September 2015
  • Convocation submissions, Bloemfontein Campus, 30 September 2015

Further, written and online submissions from the entire university community were put forward until 18 September 2015, while the Convocation had until 30 September 2015 to submit. During the process, the Language Committee has met weekly and discussed the viability, benefits and challenges of various language model options, taking into account institutional, regional, national and global concerns, documents and information.

Following the university’s commitment to open, democratic practice, the UFS calls upon all its current staff and students to participate in a campus-wide poll in order to assist the Language Committee in determining possible preferences among current staff and students for language models. The possible models have emerged from the broad consultation process.

Please note that the campus-wide poll is NOT a formal voting process or referendum and will form only one part of many deciding factors that will be referred to the UFS Council on 20 November 2015 for their deliberations regarding the future of the language policy at the UFS. The poll, conducted by the Independent Electoral Commission (IEC), will be indicative of the preferences of staff and students for possible language model options, with specific focus on language of instruction. 

The poll will take place at the following venues from 21-28 October 2015, 08:00-16:30, including the weekend:

Bloemfontein Campus: Kestell Residence Gazellie

Qwaqwa Campus: VIP Lounge

South Campus: Conference Hall

To take part in the polling, a valid staff or student card must be produced. Polling will take place on the basis of one poll per current staff member/student.

We look forward to your participation in the poll and hereby thank the entire university community for their ongoing interest and responsible engagement with the review process.

 The UFS Language Committee

 

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

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