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31 August 2022 | Story Leonie Bolleurs | Photo Supplied
Mpeti Morojele and Prof Jonathan Noble
Mpeti Morojele and Prof Jonathan Noble, Head of the UFS Department of Architecture, at the 33rd Sophia Gray Laureate exhibition at the Oliewenhuis Art Museum.

The Department of Architecture at the University of the Free State (UFS) this year hosted the first entirely face-to-face Sophia Gray lecture since the COVID-19 pandemic.

Talking about Changing Landscapes, Practice and Pedagogy, Mpeti Morojele presented the Sophia Gray lecture – the biggest and most prestigious architectural lecture of its kind in South Africa – as the 33rd Sophia Gray laureate. 

Hailing from the mountain kingdom of Lesotho, Morojele established his design practice, the award-winning MMA Design Studio in Johannesburg, in 1995.

Local and international recognition

He is recognised for his work locally and internationally. Some of his projects include the South African Embassy in Addis Ababa, Ethiopia, the South African Embassy in Berlin, Germany, the Maropeng Cradle of Humankind World Heritage Site, as well as various Freedom Park projects, including Isivivane (the symbolic final resting place for South Africa’s fallen heroes), //hapo (telling the South African story of liberation and the triumph of the human spirit over three billion years), and Isikhumbuto (a place of remembrance, a gathering space at the top of a hill surrounded by the wall of names, sanctuary, gallery of leaders, and the Moshate).

His work engages the African landscape, incorporating indigenous knowledge and ritual to respond to and enhance the emerging African condition. 

Becoming conscious

In his presentation, Morojele explained his journey as an architect. As a student at UCT, he said he felt invisible because of the kind of architecture they were talking about; mostly architecture of the Western world. He elaborated on this point in his lecture, explaining about becoming conscious. 

“It took me back to the origins of humankind. I found it interesting to consider what the architecture at our origins was, and what the environment was in which we first became conscious of ourselves. It has been said that becoming conscious was the beginning of spirituality and art. The idea of origins interested me, and also how we as humans became conscious of ourselves and the space around us, until we achieve the state where we actually create these spaces for our own use,” he said.

As we evolved and became more conscious, we not only found objects, but placed objects in ways that commemorate our unity and spirituality, signifying society coming together to build something collectively. 

Symbiotic relationship with the environment

For Morojele, animism – the belief that inanimate objects have internal and distinct spiritual essences – also played a role in his designs. “It allows us to have a symbiotic relationship with our environment, as opposed to one where we exercise dominion over all things. Animism locates us in the environment as part of it rather than as outside observers of the environment.” 

The Kigutu International Academy, located on the Village Health Works Campus 100 km south of Bujumbura in Burundi and nestled in lush mountains overlooking the beautiful Lake Tanganyika, is an example of where he places humans close to the environment. Here he essentialises the architecture. This project, with its open spaces, also brought about the question of walls. Do they unite or do they divide?

Morojele remarked that architecture takes lessons from landscapes by giving shelter, security, and prospects of freedom. 

Re-establishing what it means to be human

His goal was to plant an idea in the minds of the architects who attended the lecture. Given where we are headed in the world, we need to re-establish what it means to be human; it is only when we recognised the humanity in all of us that we can begin to use architecture to unite societies. 

In order to do this, our focus needs to be less intellectual and more about how we as biological beings behave in environments; for example, do people feel alienated or do they belong in our spaces?

“These are the important things, I think, our architects need to talk about in the future,” he concluded his lecture. 

• Examples of Morojele’s work, including drawings and designs, can be viewed at the Oliewenhuis Art Museum.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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