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18 April 2022 | Story Leonie Bolleurs | Photo Stephen Collett
Prof Ted Kroon
Prof Ted Kroon from the Department of Physics recently delivered his inaugural lecture on the topic What’s the use of a rainbow on the UFS Bloemfontein Campus.

“A rainbow is a natural phenomenon, the result of the refraction and reflection of the sun’s rays in drops of rain. As far as mankind is concerned, it’s a perfectly useless object and won’t make anyone money. Yet the poet who said, My heart leaps up when I behold a rainbow in the sky, only put into word the feeling of wonder and excitement we all have when we see a rainbow.”

“Every day I see a rainbow in my work; I do not need to wait to see one in the sky,” says Prof Ted Kroon, Professor in the Department of Physics at the University of the Free State (UFS), who used this phenomenon to introduce the topic of his inaugural lecture: What’s the use of a rainbow. 

“Far from being only a colourful spectacle with no practical value, rainbows are useful – and lead to useful things,” he believes. 

According to Prof Kroon, one can find examples of real rainbows and rainbow analogies used not only in everyday life, but also in physics. “Besides it being familiar devices in literature, culture, and even marketing, studies of rainbows can yield practical engineering information and may even help us to find new habitable planets,” he says.

Inspired by the many uses of a rainbow

In his lecture, he discussed the basic features of natural rainbows and how they come about. He also explored how the rainbow gives meaning to colour, and how this relates to the temperature of objects. He looked at an array of instances where the rainbow is used; from depicting the life of a star to indicating that we are sick (a thermometer) or when we need to refill a gas cylinder.
Moreover, Prof Kroon pointed out that rainbows are used in computer chips, stress identification, and to transmit internet data through underwater cables of glass fibre. He also referred to how the rainbow was harnessed as an engineering tool to measure refractive index and characterise fine droplet sprays used in industry. 

He continues, “Remarkably, the science developed to understand the natural rainbow can be redirected and applied to the optical properties of metallic nanoparticles, allowing the development of nanotechnology. Knowing how the natural rainbow works and its limitations, better systems have been developed to produce rainbows. Such rainbows have been used to discover new elements and to determine the age of the universe.”

As a member of an international community of phosphor researchers who are privileged to work with rainbows every day, he has used them to study the light-emitting properties of materials doped with bismuth. With this project – an initiative with the African Laser Centre taking place between 2016 and 2021 – he collaborated with the University of Khartoum in Sudan and trained a number of its postgraduate students. “My role included the guidance of students and the measurement and interpretation of the light-emitting properties of the materials. Our research during this time, considering more than a dozen materials, was summarised in 34 scientific publications that contributed to a greater understanding of bismuth ions as light-emitting materials,” he explains. 

Developing new materials, efficient in emitting blue light

He has been developing luminescent materials since 2006, primarily for general lighting (fluorescent tubes and LEDs) and displays (television, computer, and cellphone screens), as well as niche applications in medical and forensic science. 

As part of his current research, he is examining the effect of plasmonic metal nanoparticles on phosphor light emission. He is also exploring materials that absorb infrared light but emit visible light. “For this, I would like to consider the long-term stability of such materials and develop new materials that are more efficient in emitting particularly blue light,” he says. 

Prof Kroon holds a C2 rating from the National Research Foundation and has published more than 150 articles and book chapters, obtaining a Scopus h-index of 26.

News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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