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25 August 2022 | Story Rulanzen Martin | Photo Rulanzen Martin
Vency Mupupa, Jessica Lynne and Dr Nadine Lake
From the left: Vency Mupupa, Jessica Lynn and Dr Nadine Lake.

Creating residences and other spaces that adapt to change without it being forced is a process that requires time, patience, and nurturing. Through recent engagements with Jessica Lynn, a transgender activist from the Kinsey Institute in the United States, the Centre for Gender and Africa Studies (CGAS) and the Housing and Residence Affairs (HRA) division at the University of the Free State (UFS) are committing to creating dialogue and engagements that will foster gender-, transgender- and LGBTQI-positive attitudes for residences on and off the UFS campuses. 

Most of the advocacy and educating work envisaged by the CGAS and HRA did not materialise due to the COVID-19 pandemic. “There are issues coming to the forefront amongst the student community in terms of gender identity and gender fluidity on all three UFS campuses. It is visible that these issues exist, but they are not being discussed,” said Dr Nadine Lake of the CGAS. She added that the Centre would like the UFS to continue addressing issues like acceptance, inclusion, and diversity, but to also focus on gender identity and not just on race.  

Inclusive living spaces: The seed has been planted 

“We reached out to Housing and Residence Affairs (HRA) around creating more education and advocacy for students and staff within HRA around transgender identity specifically, but then also gender,” Lake said. According to Vency Mupupa, Senior Officer: Accommodation Services at HRA, the seed for a broad-based gender awareness project within on-campus residences started in 2019, when HRA was tasked with conducting research into inclusive housing. 

“The focus is not only on transgender people but the LGBTQI community at large. We are starting small, but eventually it will affect the larger student population,” Mupupa said. 

She emphasised that the focus is not only on students in residences but also on staff within HRA and the residences. “We have 25 000 students, and on-campus residences can only accommodate around 6 000 students, so it is a drop in the ocean, but if we can educate everyone else the space will move away from being unaccepting and become more inclusive.” 

Transgender awareness breaks down walls 

Referencing her own experiences, Lynn, who is a transgender woman, said that advocating for gender awareness is all about creating safe spaces for people to be their authentic self. “It is a very closeted feeling,” she said. “When I transitioned, I experienced a lot of bad things, and I wanted to use my experience to help educate others so that are not trapped the same way I was. There is a very small percentage of people worldwide who identify as transgender… It is not like there are no transgendered people here, it is just that they are scared of coming out.” 

Universities are the perfect space

Lynn decided her awareness campaigns should focus on university students because the students she reaches are the next generation of doctors, lawyers, politicians, and judges. “It is all about how we can educate the next generation.”

Most university or college students are going to progress in their careers and will be able to use their influence to educate the next generation. “But, most importantly, most of these students are going to become parents – and sooner or later one of them might become a parent to a bisexual, transgender, or gay child, and through my presentations it would have hopefully opened a lot for them to comprehend,” Lynn said. 

Lynn is internationally renowned for her transgender awareness work and advocacy, and her longstanding relationship with CGAS widened the scope to intensify this project. “Jessica’s work is very important, firstly because of her affiliation with the Kinsey Institute, but most importantly her work in transgender identity,” Dr Lake said. Lynn has presented classes, seminars and talks at some of the leading universities around the globe and in South Africa has delivered talks at the UFS and Rhodes University.

• The Department of Social Work at the UFS will host a Gender Diversity, Inclusion and Belonging Seminar with Jessica Lynn on 2 September 2022. Click here for more information. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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