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26 August 2022 | Story NONSINDISO QWABE | Photo Boitumelo Molefe
Prof Geofrey Mukwada
Prof Geofrey Mukwada from the Department of Geography on the Qwaqwa Campus delivered his inaugural lecture, which focused on elevation-dependent warming in the Drakensberg Mountain region.

South Africa is generally regarded as a thirsty country due to water scarcity nationally. Even a rise of 0,5 °C in climate temperatures could have devastating effects on the environment.

Delivering his inaugural lecture on 22 August 2022 – a first for the Qwaqwa Campus in many years – Prof Geofrey Mukwada of the Department of Geography at the University of the Free State (UFS) Qwaqwa Campus painted a picture of the long-term effects of climate change on ecological, social, and economic aspects of the environment. The effects of climate change are being felt in all regions of the world, and the Drakensberg region in particular is beginning to bear the brunt.

Elevation-dependent warming a threat to socio-ecological systems

Introducing his topic, The last days of plenty: an assessment of elevation-dependent warming in the Drakensberg Mountain region between 1980 and 2018 and its potential implications for social-ecological systems in the region and downstream communities, Prof Mukwada said ‘last days’ was a euphemism used figuratively to imply the impending loss of environmental resources in the mountains because of climate change.

According to Prof Mukwada, elevation-dependent warming in the Drakensberg would pose serious implications for the overall rural livelihoods, regional trade, and biodiversity conservation.

“The Drakensberg Mountains is made up of a chain of several mountains and is home to a lot of activities. It is important for rural livelihood, including agriculture, cultivation of different forms, fisheries, and tourism, and if the climate is therefore changing and elevation-dependent warming is taking place, we see a threat to socio-ecological systems in many ways.”

In his lecture, Prof Mukwada discussed the three-decade-long investigation to determine if elevation-dependent warming is taking place at several points of the mountains, and to assess its environmental implications for the region and downstream communities. Using a time-series analysis standardised precipitation and evaporation index (SPEI) and monthly maximum temperature and locational and elevation data, the investigation monitored climate change trends between 1980 and 2018.

Development of research-based solutions

He said results did not confirm the existence of elevation-dependent warming in the Drakensberg Mountain region, but statistically significant evidence has shown that the region is becoming warmer and facing increasing aridity.

“It is worrisome in the sense that even such a small change can have devastating effects on the environment.”

In order to avert these problems, Prof Mukwada said a special climate adaptation plan for the region was necessary. The university plays a key role in this, as it can provide guidance on the process of redefining knowledge, scientific understanding and truth, in order to promote sound mountain development interventions and programmes. “We need to shift towards research-based solutions.”

Prof Mukwada is a C2 NRF-rated researcher with expertise in the application of remote sensing and geographic information systems (GIS) in integrated scientific and multidisciplinary environmental research.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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