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26 August 2022 | Story NONSINDISO QWABE | Photo Boitumelo Molefe
Prof Geofrey Mukwada
Prof Geofrey Mukwada from the Department of Geography on the Qwaqwa Campus delivered his inaugural lecture, which focused on elevation-dependent warming in the Drakensberg Mountain region.

South Africa is generally regarded as a thirsty country due to water scarcity nationally. Even a rise of 0,5 °C in climate temperatures could have devastating effects on the environment.

Delivering his inaugural lecture on 22 August 2022 – a first for the Qwaqwa Campus in many years – Prof Geofrey Mukwada of the Department of Geography at the University of the Free State (UFS) Qwaqwa Campus painted a picture of the long-term effects of climate change on ecological, social, and economic aspects of the environment. The effects of climate change are being felt in all regions of the world, and the Drakensberg region in particular is beginning to bear the brunt.

Elevation-dependent warming a threat to socio-ecological systems

Introducing his topic, The last days of plenty: an assessment of elevation-dependent warming in the Drakensberg Mountain region between 1980 and 2018 and its potential implications for social-ecological systems in the region and downstream communities, Prof Mukwada said ‘last days’ was a euphemism used figuratively to imply the impending loss of environmental resources in the mountains because of climate change.

According to Prof Mukwada, elevation-dependent warming in the Drakensberg would pose serious implications for the overall rural livelihoods, regional trade, and biodiversity conservation.

“The Drakensberg Mountains is made up of a chain of several mountains and is home to a lot of activities. It is important for rural livelihood, including agriculture, cultivation of different forms, fisheries, and tourism, and if the climate is therefore changing and elevation-dependent warming is taking place, we see a threat to socio-ecological systems in many ways.”

In his lecture, Prof Mukwada discussed the three-decade-long investigation to determine if elevation-dependent warming is taking place at several points of the mountains, and to assess its environmental implications for the region and downstream communities. Using a time-series analysis standardised precipitation and evaporation index (SPEI) and monthly maximum temperature and locational and elevation data, the investigation monitored climate change trends between 1980 and 2018.

Development of research-based solutions

He said results did not confirm the existence of elevation-dependent warming in the Drakensberg Mountain region, but statistically significant evidence has shown that the region is becoming warmer and facing increasing aridity.

“It is worrisome in the sense that even such a small change can have devastating effects on the environment.”

In order to avert these problems, Prof Mukwada said a special climate adaptation plan for the region was necessary. The university plays a key role in this, as it can provide guidance on the process of redefining knowledge, scientific understanding and truth, in order to promote sound mountain development interventions and programmes. “We need to shift towards research-based solutions.”

Prof Mukwada is a C2 NRF-rated researcher with expertise in the application of remote sensing and geographic information systems (GIS) in integrated scientific and multidisciplinary environmental research.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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