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12 December 2022 | Story Leonie Bolleurs | Photo Leonie Bolleurs
Dr Karen Venter
Dr Venter received her PhD at the December graduation ceremonies. She focused on addressing societal challenges through the practice of engaged scholarship in community-university research partnerships for the common good.

When asked what inspired her to pursue a PhD, Dr Karen Venter, Head of the Division of Service Learning in the Directorate Community Engagement at the University of the Free State (UFS), said she wanted to make a difference in addressing societal challenges through the practice of engaged scholarship in community-university research partnerships for the common good. 

“Also, I love to learn and share knowledge – and that is exactly what I did in this PhD, titled: An integrated service-learning praxis approach for flourishment of professional development in community-higher education partnerships.” 

She explains, “My five-articles-style thesis explored the contribution of an integrated service-learning praxis approach towards the flourishment of engaged scholarship in community-higher education partnerships. The approach combined community engaged service-learning (CESL), appreciative inquiry and appreciative leadership, to advance the praxis of engaged scholarship. The study was demarcated in the field of higher education, applied in the discipline of nursing education, and contextually bound to three interrelated action research cycles and settings – for international, national, and local level engagement.”

Community members participate in the research journey

“The intent of the study was to recognise the community-led action learning of community member participants at the core action learning set,” says Dr Venter. 

The study followed a participatory action learning and action research methodology. During her research journey, she was joined by members of the community, specifically from Bloemshelter – a shelter for the homeless. “They co-constructed and completed a four-year community-led action learning pathway to holistic development (spiritual, personal, professional), which brought about holistic social change and well-being in their livelihood, moving from dependence on others to establishing viable multiple micro-enterprises,” she says.

The UFS affiliated with GULL to reward the community member participants’ action learning. “Already in 2019, GULL certified their action learning with a Professional Bachelor’s degree, while I still had to document the action research, and only now received the PhD,” says Dr Venter. 

“I am grateful to all the participants who co-created action-oriented knowledge with me in the study, from international, to national, to local level of engagement.”

Integrating a PhD with work and life

A PhD requires a lot of hard work and effort, to the point that the lines between studies, work, and life become blurred. Dr Venter acknowledged that she tried to balance work/life and study, but “I was not very good at it”. 
Passion, patience, peace, perseverance, positivity, and prayer are good principles to maintain when you are in the process of completing a PhD. – Dr Karen Venter 

She elaborates, “Studying became an integrated part of my work and life.  For the duration of my studies, I started working at 03:00 and I also did not watch any television.” She did, however, make time for herself by joining the wellness workout programme presented by the UFS, enjoyed gardening, and playing with her grandchildren. “I also tried to rest one day over weekends, and made time to praise and worship, which energised me for the next week,” she adds. 

“Passion, patience, peace, perseverance, positivity, and prayer are good principles to maintain when you are in the process of completing a PhD, she believes. 

Dr Venter says that although writing a PhD is indeed lonely, it is also an exciting journey, “especially when you reach those moments of breakthrough that can only come to life after deep reflection.” She also describes it as a deep spiritual journey. “Almost like walking in and out of a labyrinth – and where many hours become equal to a breath.

She is very grateful to her supervisors, Dr Somarie Holtzhausen, Prof Mabel Erasmus, and Dr Elanie Myburgh. “I deeply honour and salute you for your unconditional and continuous coaching, compassion, and care – guiding, supporting, motivating, mentoring, and keeping me grounded until I completed the journey.”

 

 


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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