Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
06 December 2022 | Story André Damons | Photo Sonia Small
Dr Nicholas Pearce
Prof Nicholas Pearce has joined the Faculty of Health Sciences’ management team after being appointed Head of the School of Clinical Medicine. Prof Pearce is the former Head of the Department of Surgery at the UFS and led the Universitas Hospital’s COVID-19 Task Team.

During the height of the COVID-19 pandemic, Prof Nicholas Pearce led the COVID-19 Task Team of the Universitas Academic Hospital, ensuring that the hospital not only had enough Personal protective equipment (PPEs) and beds for patients, but also that the vaccination process ran smoothly. Now, the Best Doctor of the Year for 2022 – as named during this year’s National Annual Batho Pele Excellence Awards (NBPEA) – will lead the School of Clinical Medicine in the Faculty of Health Sciences at the University of the Free State (UFS).

Prof Pearce, former Head of the Department of Surgery at the UFS who served the faculty in multiple capacities over a long period, took up this position on 1 December 2022 – a position he is looking forward to.  

Create world-class doctors, maximise students’ full potential

“I’m excited about taking up my new position as Head of the School of Clinical Medicine. This is a role that comes with huge responsibility, and my vision is to create world-class doctors and to maximise each student’s full potential.  We, as university, are a national asset and need to grow and develop to be of service to the future of our country.  So, to lead a school with such a prestigious history is truly a privilege,” says Prof Pearce. 

According to him, the goal for the Medical School in the next five years should be determined by three main core drivers: service delivery, research, and teaching and training. He would like to be in a stronger position, with innovation that can produce world-class doctors (both undergraduate and postgraduate). 

If you look at the strategic plan of the UFS, says Prof Pearce, it is clear that, under the leadership of current Rector and Vice-Chancellor, Prof Francis Petersen, a period of regeneration and innovation is upon the university. Tied to this concept is the idea of self-evaluation and improvement. The idea of challenges and coming up with solutions excites him.  

“I think for a while, my main aim will be to bring the university, the provincial Department of Health, and the school in alignment, ensuring that we are all pulling in the same direction to achieve the same goal.”  

“At the end of the day, the goal here is to provide quality health care to the people of South Africa, while the Department of Health, the university, and society each function in different environments – coming together and understanding each other’s needs and having a common goal – excellent health care in this country for all our citizens.”

Lessons learned from surgery and running COVID-19 task teams

Prof Pearce, who was awarded the UFS Chancellor’s Medal for outstanding service during the April graduation ceremonies, says lessons learned from being both a surgeon and running COVID-19 task teams, are that strategic organisational processes need to be in place – systems strengthened, the policies and procedures adapted, and comprehensive planning taking place. 

However, he says, one must also bear in mind that we have a history of very high academic standards in the School of Clinical Medicine, so you want to improve on that rather than go backwards.

“I learned a lot from surgery and COVID-19 that will equip me in future. COVID-19 taught me about organisational management, disaster management, funding, resource management, people management skills, development, etc.  
“Running the Department of Surgery, one of the largest departments in the faculty with multiple inputs and personalities, has taught me that you are only as strong as the team behind you. I have an amazing team behind me in this new role, whether it is the dean, vice-dean, heads of department, administration, rectorate, and so forth.” 

He will continue to work at the Universitas Hospital; however, being fully employed by the university, he will only be doing some calls and working over weekends.  

“As a surgeon, theatre has always been my safe haven, my place of meditation, my place of peace, and I am sad to say goodbye to surgery and the Department of Surgery – it has been loyal, and I am grateful to everyone in the department; but I think as with all good things, there is a time to come and a time to go.”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept