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17 February 2022 | Story NONSINDISO QWABE | Photo Thabiso Mdakana
Qwaqwa Campus vaccination drive
Andile Tshabalala and Theodore Hlalele, CSRC Qwaqwa Campus.

As the University of the Free State is encouraging staff and students to be vaccinated in order for all of us to return to campus life as we know it, the Qwaqwa Campus held its first in-person vaccination activation drive for its first and returning students. The drive was to further encourage students to vaccinate, and to keep themselves and others safe by educating themselves.

The cheerful and excited crowd of more than 100 students were gathered at the Amphitheatre on campus, where they got to know more about the COVID-19 Regulations and Required Vaccination Policy and interacted with Department of Health officials to understand more about the jabs and booster shots.

No one is forced, but everyone is encouraged

The university’s approved policy came into effect on 14 February, requiring staff and students to be vaccinated as a measure towards ensuring everyone’s smooth return to its three campuses. However, as Qwaqwa Campus Principal Dr Martin Mandew highlighted, “no one is being forced to vaccinate, but we are all strongly encouraged to do so”.

Dr Mandew said the student experience is too rich and vibrant to be confined to virtual learning. He showed students his own vaccination certificate, quoting a Zulu proverb, ‘indlela ibuzwa kwabaphambili’, which loosely translated means ‘those who have gone before you can show the way’.

“If you are not vaccinated, it will be impossible for us to enjoy face-to-face interaction again. Ask yourself: ‘If the principal is vaccinated, who am I not to be?” he said.

The lively drive also kept students entertained through live performances by local artists. 

Students could also raise pressing issues and questions with Department of Health officials – including common side effects, apathy against vaccination due to religious beliefs, the efficacy of the vaccine to protect against COVID-19, and the implementation of the UFS Vaccination Policy. 

The programme line-up also included messages of support from the Director: Student Affairs, Zoleka Dotwana, the Deputy Director of Housing and Residences, Zakhele Mdluli, and UVPERSU Vice-Chairperson, Dr Grey Magaiza.

The operating days of the on-campus vaccination site have been extended to accommodate streams of incoming students who still want to be vaccinated. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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