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11 February 2022 | Story Leonie Bolleurs and Nonsindiso Qwabe | Photo Supplied
The superpowers of women scientists at the UFS

The University of the Free State (UFS) has implemented several interventions to increase the diversity of its researchers, including its women scientists. Actions have paid off and resulted in an increase in the percentage of rated female researchers, from 27% in 2016 to 34% in 2021.


The university is also host to a number of science leaders in the six National Research Foundation (NRF)-funded South African Research Chairs Initiative (SARChI). Four of these research chairs are held by women. These are the research chairs in Vector-borne and Zoonotic Pathogens; Disease Resistance and Quality in Field Crops; Higher Education and Human Development; and Pathogenic Yeasts.

Health, medicine, and food sustainability are but three examples of areas in society where the women of the UFS is playing a critical role in science today.

In celebration of the International Day of Women and Girls in Science instituted by the United Nations General Assembly on 22 December 2015, the UFS is honouring its women scientists.

The science of science expos

One of the researchers at the UFS who is using science to make a difference in the lives of learners in our country, is Dr Angela Stott, Researcher and Teacher Educator in the Division of Social Responsibilities Projects (SRP) on the UFS South Campus. Together with colleagues in the SRP, she is involved in numerous Maths and Science outreach interventions to teachers and learners.

Science becomes fun for learners through the different initiatives created by Dr Stott and her colleagues. These include the online Learn Science programme (a brainchild of Dr Stott), using tablets donated by ioT.nxt, and the Creative Clubs intervention started by Dr Joleen Hamilton, a colleague of Dr Stott. In the latter, learners can take part in a MathArt competition and coding sessions.

In this year’s Creative Clubs projects, 100 Grade 9 learners from township schools will be mentored to prepare science fair projects for participation in the Expo for Young Scientists.

But why all this hard work for an expo? For these learners, the expo is more than just a public platform to showcase excellence. According to Dr Stott, learners in South African township schools tend not to be stimulated in extracurricular programmes, since teaching in these contexts is typically restricted to exam training.

However, her research has shown that higher-achieving learners from contexts of poverty respond well to such programmes and gain valuable knowledge, skills, and values from them. “This year, 100 higher-achieving Grade 9 learners from township schools will benefit from this programme, and next year another 100,” she says.

She adds that literature on this subject points to the need for structure, while also supporting learners’ development of autonomy when mentoring a learner to produce a science fair project. Dr Stott explains that the online programme around which this year’s intervention is built, has been created in a manner informed by literature on what is most likely to work. “By us researching the process, we will improve our understanding of how to maximise the benefits and mitigate the weaknesses that learners from poverty gain from such participation. This knowledge could help improve the effectiveness of such programmes throughout the country, and in other parts of the world where similar conditions apply,” she says.

Fighting for stronger immune systems

An international student from Zimbabwe, Nakai Matongera, a PhD graduate in Plant Breeding in the Department of Plant Sciences on the Bloemfontein Campus, is playing a key role in food sustainability in Africa with her research. She is a maize breeder working at the Scientific and Industrial Research and Development Centre (SIRDC) in Harare, Zimbabwe.

The focus of her PhD thesis is on the development of high-yielding and nutrient-dense maize varieties enriched with provitamin A, zinc, and essential amino acids such as lysine and tryptophan.

“With my research, I aimed to develop zinc-enhanced maize varieties that have great potential to reduce zinc deficiency in maize-based developing countries in sub-Saharan Africa,” she says.

Matongera explains that zinc-enhanced hybrids were developed by crossing introduced zinc donors and locally adapted maize inbred lines from three nutritional categories (normal, provitamin A, and quality protein maize (QPM). The hybrids were evaluated for both agronomic and nutritional performance under optimum drought and low nitrogen conditions.

“Results indicated that zinc-enhanced QPM hybrids accumulated high zinc under all growing conditions. However, the zinc-enhanced normal hybrids had the highest yield potential, implying dilution effects.”

“I find my research rewarding, because this biofortification strategy to combat micronutrient deficiency is cost-effective and has wide coverage and sustainability compared to other strategies such as clinical supplementation and food fortification,” says Matongera.

The outcomes of her research will one day, when it is implemented, change the lives of thousands of children in Africa who are suffering from zinc and iron deficiency. The shortage of zinc and iron in their diets affects their cognitive development as well as their immune systems, making them susceptible to a number of illnesses, including diarrhoea.

According to Prof Maryke Labuschagne, Nakai’s supervisor for her PhD study, this research will have a practical impact in Africa, as it will contribute towards the nutritional value of food.

Saving generations of humans and animals

When she could not pursue her childhood dream of becoming a vet, Dr Nthatisi Nyembe forged a new path in zoology, and today she is working in the Department of Zoology and Entomology on the UFS Qwaqwa Campus, where she focuses on veterinary parasitology.

Dr Nyembe’s research looks at the treatment and epidemiology of parasitic diseases in animals and humans, because – as she says – if animals are healthy, then humans are healthy. She says the ripple effect could save generations to come. “I want to be remembered for creating a drug that will make life easier for animals, because if animals are healthy, then the food we consume will also be healthy,” she says.

Dr Nyembe completed her studies on the Qwaqwa Campus from undergraduate to master’s level, specialising in Zoology. She was then awarded a scholarship to complete her PhD studies in Japan, where she spent four years looking into creating compounds that can treat and prevent unwanted parasites in animals, with a specific focus on mice.

“If I can get to a point where I can find one compound that has various benefits on multiple micro-organisms, then I will be happy”, she says.

While acknowledging the wide gender gap that still persists in her field of science, Nyembe says it should not hinder young girls who are interested in pursuing all levels of science.

“Society still looks down on girls and women, especially in Africa. If I go to a farmer as a woman and try to advise them about animal health, very few of them are receptive. However, the majority believe that I need to come with a man in order to be taken seriously. I just want to tell young aspiring female scientists that it is possible.”

“Whatever you put your mind to, you can pull through and achieve. Don’t allow yourself to be intimidated.”

News Archive

Fight against Ebola virus requires more research
2014-10-22

 

Dr Abdon Atangana
Photo: Ifa Tshishonge
Dr Abdon Atangana, a postdoctoral researcher in the Institute for Groundwater Studies at the University of the Free State (UFS), wrote an article related to the Ebola virus: Modelling the Ebola haemorrhagic fever with the beta-derivative: Deathly infection disease in West African countries.

“The filoviruses belong to a virus family named filoviridae. This virus can cause unembellished haemorrhagic fever in humans and nonhuman monkeys. In literature, only two members of this virus family have been mentioned, namely the Marburg virus and the Ebola virus. However, so far only five species of the Ebola virus have been identified, including:  Ivory Coast, Sudan, Zaire, Reston and Bundibugyo.

“Among these families, the Ebola virus is the only member of the Zaire Ebola virus species and also the most dangerous, being responsible for the largest number of outbreaks.

“Ebola is an unusual, but fatal virus that causes bleeding inside and outside the body. As the virus spreads through the body, it damages the immune system and organs. Ultimately, it causes the blood-clotting levels in cells to drop. This leads to severe, uncontrollable bleeding.

Since all physical problems can be modelled via mathematical equation, Dr Atangana aimed in his research (the paper was published in BioMed Research International with impact factor 2.701) to analyse the spread of this deadly disease using mathematical equations. We shall propose a model underpinning the spread of this disease in a given Sub-Saharan African country,” he said.

The mathematical equations are used to predict the future behaviour of the disease, especially the spread of the disease among the targeted population. These mathematical equations are called differential equation and are only using the concept of rate of change over time.

However, there is several definitions for derivative, and the choice of the derivative used for such a model is very important, because the more accurate the model, the better results will be obtained.  The classical derivative describes the change of rate, but it is an approximation of the real velocity of the object under study. The beta derivative is the modification of the classical derivative that takes into account the time scale and also has a new parameter that can be considered as the fractional order.  

“I have used the beta derivative to model the spread of the fatal disease called Ebola, which has killed many people in the West African countries, including Nigeria, Sierra Leone, Guinea and Liberia, since December 2013,” he said.

The constructed mathematical equations were called Atangana’s Beta Ebola System of Equations (ABESE). “We did the investigation of the stable endemic points and presented the Eigen-Values using the Jacobian method. The homotopy decomposition method was used to solve the resulted system of equations. The convergence of the method was presented and some numerical simulations were done for different values of beta.

“The simulations showed that our model is more realistic for all betas less than 0.5.  The model revealed that, if there were no recovery precaution for a given population in a West African country, the entire population of that country would all die in a very short period of time, even if the total number of the infected population is very small.  In simple terms, the prediction revealed a fast spread of the virus among the targeted population. These results can be used to educate and inform people about the rapid spread of the deadly disease,” he said.

The spread of Ebola among people only occurs through direct contact with the blood or body fluids of a person after symptoms have developed. Body fluid that may contain the Ebola virus includes saliva, mucus, vomit, faeces, sweat, tears, breast milk, urine and semen. Entry points include the nose, mouth, eyes, open wounds, cuts and abrasions. Note should be taken that contact with objects contaminated by the virus, particularly needles and syringes, may also transmit the infection.

“Based on the predictions in this paper, we are calling on more research regarding this disease; in particular, we are calling on researchers to pay attention to finding an efficient cure or more effective prevention, to reduce the risk of contamination,” Dr Atangana said.


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