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11 February 2022 | Story Leonie Bolleurs and Nonsindiso Qwabe | Photo Supplied
The superpowers of women scientists at the UFS

The University of the Free State (UFS) has implemented several interventions to increase the diversity of its researchers, including its women scientists. Actions have paid off and resulted in an increase in the percentage of rated female researchers, from 27% in 2016 to 34% in 2021.


The university is also host to a number of science leaders in the six National Research Foundation (NRF)-funded South African Research Chairs Initiative (SARChI). Four of these research chairs are held by women. These are the research chairs in Vector-borne and Zoonotic Pathogens; Disease Resistance and Quality in Field Crops; Higher Education and Human Development; and Pathogenic Yeasts.

Health, medicine, and food sustainability are but three examples of areas in society where the women of the UFS is playing a critical role in science today.

In celebration of the International Day of Women and Girls in Science instituted by the United Nations General Assembly on 22 December 2015, the UFS is honouring its women scientists.

The science of science expos

One of the researchers at the UFS who is using science to make a difference in the lives of learners in our country, is Dr Angela Stott, Researcher and Teacher Educator in the Division of Social Responsibilities Projects (SRP) on the UFS South Campus. Together with colleagues in the SRP, she is involved in numerous Maths and Science outreach interventions to teachers and learners.

Science becomes fun for learners through the different initiatives created by Dr Stott and her colleagues. These include the online Learn Science programme (a brainchild of Dr Stott), using tablets donated by ioT.nxt, and the Creative Clubs intervention started by Dr Joleen Hamilton, a colleague of Dr Stott. In the latter, learners can take part in a MathArt competition and coding sessions.

In this year’s Creative Clubs projects, 100 Grade 9 learners from township schools will be mentored to prepare science fair projects for participation in the Expo for Young Scientists.

But why all this hard work for an expo? For these learners, the expo is more than just a public platform to showcase excellence. According to Dr Stott, learners in South African township schools tend not to be stimulated in extracurricular programmes, since teaching in these contexts is typically restricted to exam training.

However, her research has shown that higher-achieving learners from contexts of poverty respond well to such programmes and gain valuable knowledge, skills, and values from them. “This year, 100 higher-achieving Grade 9 learners from township schools will benefit from this programme, and next year another 100,” she says.

She adds that literature on this subject points to the need for structure, while also supporting learners’ development of autonomy when mentoring a learner to produce a science fair project. Dr Stott explains that the online programme around which this year’s intervention is built, has been created in a manner informed by literature on what is most likely to work. “By us researching the process, we will improve our understanding of how to maximise the benefits and mitigate the weaknesses that learners from poverty gain from such participation. This knowledge could help improve the effectiveness of such programmes throughout the country, and in other parts of the world where similar conditions apply,” she says.

Fighting for stronger immune systems

An international student from Zimbabwe, Nakai Matongera, a PhD graduate in Plant Breeding in the Department of Plant Sciences on the Bloemfontein Campus, is playing a key role in food sustainability in Africa with her research. She is a maize breeder working at the Scientific and Industrial Research and Development Centre (SIRDC) in Harare, Zimbabwe.

The focus of her PhD thesis is on the development of high-yielding and nutrient-dense maize varieties enriched with provitamin A, zinc, and essential amino acids such as lysine and tryptophan.

“With my research, I aimed to develop zinc-enhanced maize varieties that have great potential to reduce zinc deficiency in maize-based developing countries in sub-Saharan Africa,” she says.

Matongera explains that zinc-enhanced hybrids were developed by crossing introduced zinc donors and locally adapted maize inbred lines from three nutritional categories (normal, provitamin A, and quality protein maize (QPM). The hybrids were evaluated for both agronomic and nutritional performance under optimum drought and low nitrogen conditions.

“Results indicated that zinc-enhanced QPM hybrids accumulated high zinc under all growing conditions. However, the zinc-enhanced normal hybrids had the highest yield potential, implying dilution effects.”

“I find my research rewarding, because this biofortification strategy to combat micronutrient deficiency is cost-effective and has wide coverage and sustainability compared to other strategies such as clinical supplementation and food fortification,” says Matongera.

The outcomes of her research will one day, when it is implemented, change the lives of thousands of children in Africa who are suffering from zinc and iron deficiency. The shortage of zinc and iron in their diets affects their cognitive development as well as their immune systems, making them susceptible to a number of illnesses, including diarrhoea.

According to Prof Maryke Labuschagne, Nakai’s supervisor for her PhD study, this research will have a practical impact in Africa, as it will contribute towards the nutritional value of food.

Saving generations of humans and animals

When she could not pursue her childhood dream of becoming a vet, Dr Nthatisi Nyembe forged a new path in zoology, and today she is working in the Department of Zoology and Entomology on the UFS Qwaqwa Campus, where she focuses on veterinary parasitology.

Dr Nyembe’s research looks at the treatment and epidemiology of parasitic diseases in animals and humans, because – as she says – if animals are healthy, then humans are healthy. She says the ripple effect could save generations to come. “I want to be remembered for creating a drug that will make life easier for animals, because if animals are healthy, then the food we consume will also be healthy,” she says.

Dr Nyembe completed her studies on the Qwaqwa Campus from undergraduate to master’s level, specialising in Zoology. She was then awarded a scholarship to complete her PhD studies in Japan, where she spent four years looking into creating compounds that can treat and prevent unwanted parasites in animals, with a specific focus on mice.

“If I can get to a point where I can find one compound that has various benefits on multiple micro-organisms, then I will be happy”, she says.

While acknowledging the wide gender gap that still persists in her field of science, Nyembe says it should not hinder young girls who are interested in pursuing all levels of science.

“Society still looks down on girls and women, especially in Africa. If I go to a farmer as a woman and try to advise them about animal health, very few of them are receptive. However, the majority believe that I need to come with a man in order to be taken seriously. I just want to tell young aspiring female scientists that it is possible.”

“Whatever you put your mind to, you can pull through and achieve. Don’t allow yourself to be intimidated.”

News Archive

Mushrooms, from gourmet food for humans to fodder for animals
2016-12-19

Description: Mushroom research photo 2 Tags: Mushroom research photo 2 

From the UFS Department of Microbial Biochemical and
Food Biotechnology are, from left: Prof Bennie Viljoen,
researcher,
MSc student Christie van der Berg,
and PhD student Christopher Rothman
Photo: Anja Aucamp

Mushrooms have so many medicinal applications that humans have a substance in hand to promote long healthy lives. And it is not only humans who benefit from these macrofungi growing mostly in dark spaces.

“The substrate applied for growing the mushrooms can be used as animal fodder. Keeping all the medicinal values intact, these are transferred to feed goats as a supplement to their daily diet,” said Prof Bennie Viljoen, researcher in the Department of Microbial, Biochemical and Food Biotechnology at the UFS.

Curiosity and a humble start
“The entire mushroom project started two years ago as a sideline of curiosity to grow edible gourmet mushrooms for my own consumption. I was also intrigued by a friend who ate these mushrooms in their dried form to support his immune system, claiming he never gets sick. The sideline quickly changed when we discovered the interesting world of mushrooms and postgraduate students became involved.

“Since these humble beginnings we have rapidly expanded with the financial help of the Technology Transfer Office to a small enterprise with zero waste,” said Prof Viljoen. The research group also has many collaborators in the industry with full support from a nutraceutical company, an animal feed company and a mushroom growers’ association.

Prof Viljoen and his team’s mushroom research has various aspects.

Growing the tastiest edible mushrooms possible
“We are growing gourmet mushrooms on agricultural waste under controlled environmental conditions to achieve the tastiest edible mushrooms possible. This group of mushrooms is comprised of the King, Pink, Golden, Grey, Blue and Brown Oysters. Other than the research results we have obtained, this part is mainly governed by the postgraduate students running it as a business with the intention to share in the profit from excess mushrooms because they lack research bursaries. The mushrooms are sold to restaurants and food markets at weekends,” said Prof Viljoen.

Description: Mushroom research photo 1 Tags: Mushroom research photo 1 

Photo: Anja Aucamp

Natural alternative for the treatment of various ailments
“The second entity of research encompasses the growth and application of medicinal mushrooms. Throughout history, mushrooms have been used as a natural alternative for the treatment of various ailments. Nowadays, macrofungi are known to be a source of bioactive compounds of medicinal value. These include prevention or alleviation of heart disease, inhibition of platelet aggregation, reduction of blood glucose levels, reduction of blood cholesterol and the prevention or alleviation of infections caused by bacterial, viral, fungal and parasitic pathogens. All of these properties can be enjoyed by capsulation of liquid concentrates or dried powdered mushrooms, as we recently confirmed by trial efforts which are defined as mushroom nutriceuticals,” he said.

Their research focuses on six different medicinal genera, each with specific medicinal attributes:
1.    Maitake: the most dominant property exhibited by this specific mushroom is the reduction of blood pressure as well as cholesterol. Other medicinal properties include anticancer, antidiabetic and immunomodulating while it may also improve the health of HIV patients.
2.    The Turkey Tail mushroom is known for its activity against various tumours and viruses as well as its antioxidant properties.
3.    Shiitake mushrooms have antioxidant properties and are capable of lowering blood serum cholesterol (BSC). The mushroom produces a water-soluble polysaccharide, lentinan, considered to be responsible for anticancer, antimicrobial and antitumour properties.
4.    The Grey Oyster mushroom has medicinal properties such as anticholesterol, antidiabetic, antimicrobial, antioxidant, antitumour and immunomodulatory properties.
5.    Recently there has been an increased interest in the Lion’s Mane mushroom which contains nerve growth factors (NGF) and may be applied as a possible treatment of Alzheimer’s disease as this compound seems to have the ability to re-grow and rebuild myelin by stimulating neurons.
6.    Reishi mushrooms are considered to be the mushrooms with the most medicinal properties due to their enhancing health effects such as treatment of cancer, as well as increasing longevity, resistance and recovery from diseases.


Description: Mushroom research photo 3 Tags: Mushroom research photo 3


Valuable entity for the agricultural sector
Another research focus is the bio-mushroom application phenome, to break down trees growing as encroaching plants. This research is potentially very valuable for the agricultural sector in the areas where Acacia is an encroaching problem. With this process, waste products are upgraded to a usable state. “It is therefore, possible to convert woody biomass with a low digestibility and limited availability of nutrients into high-quality animal fodder. By carefully selecting the right combination of fungus species to ferment agro-wastes, a whole host of advantages could become inherently part of the substrate. Mushrooms could become a biotechnological tool used to ‘inject’ the substrate that will be fed to animals with nutrition and/or medicine as the need and situation dictates,” said Prof Viljoen.

 

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