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Prof Stephan Brown
Prof Stephan Brown is a Principal Specialist and Head of the Division of Paediatric Cardiology in the Department of Paediatrics and Child Health in the Faculty of Health Sciences at the University of the Free State (UFS).

Paediatric heart specialists at the Universitas Academic Hospital and the University of the Free State (UFS) hope their research into the deadly Cyanotic Heart Disease amongst newborns will assist health authorities in central South Africa to restructure healthcare services and do better health-planning to save more lives.

Prof Stephen Brown, Principal Specialist and Head of the Division of Paediatric Cardiology in the Department of Paediatrics and Child Health in the Faculty of Health Sciences at the UFS, says children from poor and rural areas in central South Africa are dying of Cyanotic Heart Disease. One of the main contributors to these deaths is the distance patients have to travel to regional hospitals. 

The research was done under the auspices of the Robert W M Frater Cardiovascular Research Centre in the department of cardiothoracic surgery in the UFS School of Medicine. The results are still in the preliminary stage as the final data is still being analysed. The Robert W M Frater Cardiovascular Research Centre (the Frater Centre) was established in 2015 under the leadership of Prof. Francis E Smit. This was made possible through donor funding, especially by Dr Robert W M Frater MD PhD (honoris causa, UFS), a South Africa-born New York-based cardiothoracic surgeon, researcher and innovator as infrastructure and project support by the UFS.

The vision of the Frater Centre is to be a leading cardiovascular research institution in South Africa and sub-Saharan Africa. It provides an interdisciplinary training and research platform for scientists and clinicians from different backgrounds to develop as researchers and collaborators in cardiovascular and thoracic surgery and related domains. Activities are focused on the development of African solutions for African problems.

According to Prof Brown, who is also a paediatric cardiologist at the Universitas Hospital, children with this disease present with a blueish colour because the oxygenated and desaturated blood mixes, leading to the blue discoloration. Prof Brown and his master’s degree researcher (Marius van Jaarsveld) focused on single ventricle physiologies; children who effectively have a single pumping chamber which means one of the chambers is underdeveloped or not developed at all. A normal person has two pumping chambers.  

“With this study we looked over 20 years of cases. Over this period we saw 154 children. It is a retrospective study because we are fortunate to have a very extensive database dating back to 1987. One thing of concern is that we should have seen a lot more children if you look at the worldwide statistics,” says Prof Brown.

Treatment 

According to him, 40 of these children never received any form of therapy for the simple reason that a lot of them presented too late while others had severe birth asphyxia when they got to the hospital. 

Treatment for Cyanotic Heart Disease usually involves up to three operations before the children become pink again. “The first operation is called palliation to ensure we control the lung blood. That is usually in the first to two to six weeks after birth. The second operation is done between six months to a year of age when we do to what we call a bidirectional Glen – second-stage palliation. Also to improve general condition and take some of the volume off the heart. The last operation, called the Fontan operation, happens between six to seven years of age and that’s when they become pink,” explains Prof Brown.

Prof Brown says the results from the study compare favorably with the rest of South Africa and Africa but do not compare that well to high-income countries because they have more resources available. 

They have seen children from Northern Cape, North West, some parts of the Eastern Cape and Lesotho. According to Prof Brown, once they looked closer, they discovered that the closer the patients are to the hospital, the sooner they present to hospital. The further away they are, the longer it takes them to present at a hospital with congenital cardiac facilities. 

“In Mangaung we saw the kids when they were around about four days old. At Thabo Mofutsanyana district in Qwaqwa we saw them three to four days after birth. So they presented early. Lejweleputswa and Xhariep districts we saw the patients after they were one month old. In densely populated areas it is picked up early, as they are closer to the referral hospitals. The further, away from a hospital, the longer it takes to get to us. In Lesotho it takes up to six months [for them to get to us] and the Northern Cape up to two months of age,” explains Prof Brown.

This is most likely an indication that distance from the hospitals plays a major role in deaths. 

How will the study help? 

Though a part of the study is for epidemiological information, Prof Brown hopes that the health authorities will take stock of the findings. “These studies are important to make health authorities aware of the challenges and to assist in health planning. What can we do better for the people? We are doing clinical research. This is important because we are a mid- to low-income country with limited resources and it is important for the population we are dealing with.”
“Our prime aim is if one knows what is going on in your population you can restructure your health care accordingly. That is our ultimate aim. Get it published and talk to the authorities. Now we can scientifically prove instead of relying on perception.”

The solution

Prof Brown says this disease can potentially be prevented by doing foetal heart sonar scans. If there is a huge screening project, a large number of deaths can potentially be prevented. Maternal screening is very important. Early referrals are also a step in the right direction. “Our parents, caregivers, and nurses need to be educated. Another solution is to do a simple saturation screening monitor prior to discharge after birth. I have been advocating for this for years and hopefully, before I retire, it will become routine procedure. Obviously there will be a lot of false positives, but we can help our people by earlier recognition of cyanosis.”

• Prof Brown, who is passionate about the health of children, says a life-saving collaboration initiative between the UFS, the Mother and Child Academic Hospital (MACAH) Foundation, and the Discovery Fund started five years ago to help curb the death of young patients due to congenital heart disease, and to make services more accessible to rural communities. With this outreach initiative, Prof Brown travels to rural areas in the Free State to diagnose heart defects in babies early. 

News Archive

Mathatha Tsedu to deliver King Moshoeshoe lecture
2009-06-29

Mathatha Tsedu 
The former Editor of City Press, Mathatha Tsedu, will deliver the Second King Moshoeshoe Memorial Lecture at the University of the Free State in Bloemfontein on Wednesday, 9 September 2009.

The King Moshoeshoe Memorial Lecture series are an initiative of the University of the Free State to honour the leadership legacy of King Moshoeshoe I, founder of the Basotho nation. The lecture series aim to provide a platform for debate about the key challenges of nation-building, reconciliation and leadership facing our country and the African continent.

In 2004 the UFS produced a documentary on the life of King Moshoeshoe I as part of the project to pay tribute to this great African leader. The documentary was screened numerous times on SABC TV.

Later in 2006, the inaugural King Moshoeshoe Memorial Lecture was delivered by Prof Njabulo Ndebele, former vice-chancellor of the University of Cape Town.

Mr Tsedu is one of South Africa’s foremost journalists and social commentators. He will speak on the topic, “When globalisation ties the fate of the Maluti to that of the ice caps on the Alps, what does Morena Moshoeshoe teach us about leadership today?”

Mr Tsedu has received several awards, including the Nat Nakasa Award for Courageous Journalism in 2000 as well as the Shanduka Lifetime Achievers Award in 2007.

A graduate of the University of the Witwatersrand, he started his career in journalism as a bureau reporter for the Sowetan in 1978 responsible for the then Northern Transvaal. Later Mr Tsedu became Political Editor of the Sowetan, the Deputy Editor of The Star as well as the Deputy Editor of the Sunday Independent and Deputy Chief Executive of SABC News.

He has also been the Editor of two major Sunday newspapers, the Sunday Times and City Press and is currently the Head of the Journalism Academy at the Media24 group.

Mr Tsedu is the Chairperson of The African Editors Forum and a Council Member of the South African National Editors’ Forum (SANEF). He has addressed various organisations on journalism in South Africa, including the International Federation of Journalists; the International Confederation of Free Trade Unions; the Botswana Journalist Association; the Zimbabwe Union of Journalists; the Kenya Union of Journalists; and the Union of African Journalists.

He was an active trade unionist and national executive member of the Media Workers’ Association of South Africa. He was detained several times, banned and restricted to Seshego in the Northern Province from 1981 to 1986.

Mr Tsedu is also a short story writer with several of his stories published in various magazines. He was awarded a prestigious Nieman Fellowship in 1996/97 to study at Harvard University in the United States of America.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
29 June 2009

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