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11 July 2022 | Story Valentino Ndaba | Photo Pexels
Dr Maramura
Dr Tafadzwa Maramura says she carved her path by remaining focused and resolute on her journey.

The African proverb ‘it takes a village to raise a child’ conveys the message that it requires many people to provide a safe and healthy environment for children. The village gives the child the security needed to develop and be able to realise their hopes and dreams. 

Dr Tafadzwa Maramura believes that the same applies vice versa. “It takes a good child to be raised by a village. You need to understand that the village can only do so much, the rest lies on your shoulders as the child,” she says.

The journey of a child raised by a village
The senior lecturer reflects on the journey that led her to serve in the Department of Public Administration and Management at the University of the Free State. At the age of three, she lost her father, who was an army general in Zimbabwe. Soon after, her academic journey would begin at a boarding school. Her widowed mother then moved her to a mission school due to financial constraints, seeing that she had two more children relying on her for survival. Since her father served in the government, she qualified for a state scholarship, which saw her launch her academic career in South Africa as an undergraduate student. 

“I came to South Africa in 2010 and pursued a Bachelor of Social Science degree in Development Economics at the University of Fort Hare. Once my honours were conferred, I acquired my master’s within a year. Thereafter, I enrolled at the North-West University, where I completed my PhD within two years.”

Dr Maramura was the Vice-Chancellor’s valedictorian for her bachelor, honours, and 
master’s degrees. Graduating cum laude was another way of ensuring that she pays it forward to the village that raised her. Not only was she funded by the Zimbabwean government, but she also received financial aid from South Africa throughout her studies. 

Once a child, now part of the village 
Today, as founder of a foundation based in Zimbabwe, she pays the fees of orphaned and disadvantaged primary school learners. “I wish everyone could adopt a child, pay their fees, buy their schoolbooks – because we only have each other, we do not have anyone else. That’s also part of what I call co-creating.”

The Brightest Young Minds in Africa alumna goes above and beyond focusing on academics, as she believes that “if you are the only one holding the light, everyone else will have to follow behind you to make sure that they can see ahead. However, if you share that light, then it means many more can see, therefore making it easier to solve societal challenges as a collective”.

She argues that the amount of money you spend on lunch could pay a child’s school fees for a term, and the cash that you use to buy a jacket or a pair of shoes, could cover a child’s fees for a month.
Making a difference in the lives of young children is her way of playing the role of the village now that she is an adult. “I make sure that wherever I am, I make an impact in the lives of others.”

Dr Maramura says she plans to make sure that life is better for the next young African female, by setting up a mentorship programme for the next generation of leaders. In addition to that, her goal is to become an associate professor, rise in academic rank, and develop a research unit that can speak to issues of sustainable service delivery.

On how to be a good child 
You do not need to be a figure of authority to make an impact. According to Dr Maramura, all you need is a desire to co-create, and making sure that the public is in a different place after you have left the relevant office you hold or the organisation you serve. “Make sure that you can co-exist, because humans don’t live in a vacuum, we exist among each other.”

Serving the people makes all the difference. She suggests that everyone asks themselves what they are doing for their community, class, or family. 

News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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