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11 July 2022 | Story Andre Damons | Photo Supplied
Prof Martie Smith and Prof Drik Opperman
Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin. 

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products.  This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.  

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.  

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.  

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties. 

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows. 

The two funds are: 

1.  The Industrial Engagement Fund 
2.  The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:



News Archive

UFS is the most integrated campus in the country
2010-01-29

 
 Judge Ian van der Merwe, Chairperson of the University of the Free State's (UFS) Council and Prof. Jonathan Jansen, Rector and Vice-Chancellor of the UFS at the official opening ceremony.
Photo: Hannes Pieterse

“The University of the Free State’s (UFS) Main Campus is the most integrated campus in the country.”

This was said by Prof. Jonathan Jansen, Rector and Vice-Chancellor of the UFS during the university’s official opening on its Main Campus in Bloemfontein today.

Addressing staff and students, Prof. Jansen said that the first-year students in the majority of the residences are now fully integrated on a 50/50 basis. “The majority of our house committees are now also integrated,” he said.

He used the ladies residence Welwitschia as an example. “When I walked into to this residence last year it consisted only of black female students. When I visited them again this year I could not believe what I saw: the residence is fully integrated and there are white and black students living together. This is an example of our young people’s willingness to live together and we must believe in their potential,” he said.

Prof. Jansen said that the UFS does not want to be good because “good is the enemy of great” (from Jim Collins in his book Good to Great). “We want to be great. This is the year in which our staff and students’ lives will change and this university will change as we take the first steps in making the leap from good to great,” he said.

Prof. Jansen said that there have been many developments at the UFS so far this year. “We have attracted some of the best scholars in the country and other parts of the world to this university, and we will be selecting from among them in the next two weeks. We have also attracted some of the best athletes in the country in our first-year class, including some of the best hockey players,” he said.

Prof. Jansen outlined the following as his priorities for 2010:

  • The phasing in of compulsory class attendance as a way to drastically improve the quality of teaching at the UFS. “This will also enhance our throughput. However, before we can to this, we are going to accelerate the building of larger classrooms to accommodate all our students,” he said.
  • The appointment of a senior vice-rector in the near future, who will manage the day to day operations of the UFS;
  • To market the UFS to the best and most promising schools in South Africa. “This will start next week when I will be visiting schools in the Eastern Cape.”
  • To raise R100 million to enable more students with talent to study at the UFS, and to build an endowment to be proud of for the future of the university;
  • To upgrade the infrastructure in the residences;
  • To require every member of the university’s academic staff to publish every year;
  • To train administrative and support staff so that a world-class service culture can be created which takes every student, every parent and every staff member seriously; and
  • To insist that the conditions of service of staff working for agencies outside the UFS be improved by increasing the minimum remuneration dramatically and by making study benefits available to them as well. “We will not renew our tenders with outside agencies unless they raise the minimum wage of their staff,” he said.

Prof. Jansen said that he was extremely proud of the Student Representative Council’s (SRC) leadership and what they have achieved so far during their term. He also thanked the staff for their hard work and the excellence they bring to the UFS.
 

Media release
Issued by: Lacea Loader
Director: Strategic Communication (actg)
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl@ufs.ac.za  
29 January 2010
 

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