Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
11 July 2022 | Story Andre Damons | Photo Supplied
Prof Martie Smith and Prof Drik Opperman
Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin. 

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products.  This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.  

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.  

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.  

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties. 

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows. 

The two funds are: 

1.  The Industrial Engagement Fund 
2.  The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:



News Archive

Construction at Qwaqwa Campus creates jobs for local community
2010-05-28

At the construction site hand-over ceremony are, from the left: Dr
Elias Malete, Dr Dipane Hlalele, Prof. WF van Zyl and Mr Derek Canavan
(Freelance Construction)
Photo: Thabo Kessah


Local labour is set to benefit from at least 20 job opportunities that will be created during the building of new facilities valued at R13,5 million for the Faculty of Education on the Qwaqwa Campus of the University of the Free State (UFS).

This was announced by Mr Derek Canavan, an architect from Freelance Construction, during the sod-turning ceremony held on the construction site recently.

The soon to be built facilities will include a 100-seater lecture hall, two 50-seater classrooms, an office block, ablution facilities, two separate laboratories for biology and science, as well as an IT laboratory with 70 work stations. All these facilities will be user-friendly to the disabled students.

Addressing a contingent of brains behind the project that included Mr Nico Janse van Rensburg, Manager of Physical Planning at the UFS, Dr Elias Malete, the Qwaqwa Campus Principal, said that this addition to the existing infrastructure would enable the campus to meet its enrolment and output challenges.

“These new facilities will no doubt increase the university’s academic and research capacity and will certainly help us respond positively to Minister Blade Nzimande’s call to institutions of higher learning to improve on scientific research. We are therefore pleased with this multi-million rand investment from the National Department of Education and the UFS,” he concluded.

Also attending was Dr Dipane Hlalele, Programme Head in the faculty, who was also pleased with the new facilities. “These facilities will help us to answer to our community’s needs of pre-school and foundation-phase teacher training which will be added to our study programme in January 2011. We will be introducing a new B.Ed. degree in Pre-school and Foundation phases and these facilities will help in the production of quality teachers for the benefit of our community,” he said.

The new building is expected to be ready for usage in June 2011.

Media Release
Issued by: Lacea Loader
Director: Strategic Communication (acting)
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl@ufs.ac.za  
27 May 2010
 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept